This study compares the pharmacokinetics of two preparations of slow-release theophylline, one of them already known, and the other one a new product (micronized), very well accepted by pediatric patients. Two similar groups of fifteen patients each all of then asthmatic children under ten years of age, were selected and given a single oral dose of 10 mg/kg of one of the preparations. The pharmacokinetic parameters (T 1/2, Kel, VD, Cl and AUC) did not differ between both groups. The new product could further be used more safely, due to its lower incidence of "erratic" behaviour.

Asthma↗

PubMed1977

Bilateral seminoma 34 years after orchiopexy.

A case of bilateral seminoma in a 59-year-old patient who had undergone bilateral orchiopexy 34 years previously is presented. To our knowledge this is the longest interval between an orchiopexy and diagnosis of bilateral malignancy.

Age Factors↗

PubMedDate not supplied

Distinct quality of depressed mood: an attempt to develop an objective measure.

Since the time of Kraepelin, in continental Europe the sadness of depression has been considered to have a "distinct quality' basic to the diagnosis of pathological depression. This distinct quality has been interpreted by observers but patients have been noted to have difficulty verbalizing differences from normal sadness. The authors have used a discriminant analysis to study how patients define pathological sadness and as a result have developed a Pathological Sadness Index with a sensitivity of 0.94, a specificity of 0.96 and a total misclassification rate of 5% (kappa w = 0.90).

Adjustment Disorders↗