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L Cacciatore

Publications and source records attributed to L Cacciatore.

At least 37 records · Page 2Linked to original sources
PubMed1983

Differential diagnosis between hepatic cirrhosis and chronic active hepatitis: specificity and sensitivity of physical and laboratory findings in a series from the Mediterranean area.

Sensitivity and specificity of physical and laboratory findings have been evaluated for the purpose of establishing a differential diagnosis between cirrhosis and chronic active hepatitis on clinicolaboratory grounds. Data from 213 patients from southern Italy with biopsy-proven chronic active hepatitis or cirrhosis have been studied retrospectively. Splenomegaly, hypocholesterolemia, and decreased sulfobromophthalein-Ki were among the most sensitive individual findings in cirrhosis, whereas decreased platelet count, jaundice, and hypoprothrombinemia were the most specific ones. The presence in the same patient of both one of the former and one of the latter findings yields a correct diagnosis of cirrhosis with at least 90% likelihood. Advantages of the proposed diagnostic technique and comparison with data from an American series are discussed.

Adolescent↗
PubMed1982

[Plasma insulin and glucagon during experimental MHV-3 virus hepatitis in mice].

Insulin and glucagon values were determined in the plasma of mice during MHV-3 experimental viral infection. The results showed a different behaviour of the two hormones. The insulin values remained normal until the 12th hour of infection, with a statistically significant increase as from the 12th hour up to their maximum peak at the 24th hour, remaining constant at that level until the 72nd hour. As for the glucagon values there was a statistically significant decrease until the 24th hour of infection when they suddenly began to increase up to their maximum peak at the 48th hour remaining constant at that level until the 72nd hour. Increased of the insulin values may be attributed to liver cell damage because of the decreased metabolization of the hormone. As for glucagon the results of the decreased values during the initial phase of the infection may be the concentration decrease of free plasma amino acids, whereas the increased values during the subsequent phases is probably caused by the concentration increase of free plasma amino acids, of hypogycemia and of stress.

Amino Acids↗
PubMed1979

Influx of glycyl-proline and free amino acids across intestinal brush border of phenobarbital-treated rats.

In a previous study the authors have shown that treatment with phenobarbital in the rat is followed by a generalized increase of amino acid concentration in the plasma. In order to better clarify this phenomenon, the effect of phenobarbital on intestinal protein absorption was now studied by measuring the influxes of Glycyl-L-Proline, L-Phenylalanine, L-Lysine and L-Glutamic acid across the brush border of jejunum and ileum in rats treated with phenobarbital for two or four days. No significant changes of these influxes were observed in the treated animals as compared to the controls, hence suggesting that the effect of phenobarbital on plasma levels of free amino acids is not mediated by an effect on intestinal absorption. The rate of Glycyl-Proline influx as compared to those of amino acid influxes suggests the occurrence of a carrier-mediated transport process for this dipeptide in the rat intestine as previously shown in the rabbit.

Amino Acids↗
PubMed1978

[Clinical enzyme diagnosis in chronic hepatitis. Possibilities and limitations (author's transl)].

The determination of enzyme activity in serum for the diagnosis of chronic hepatitis has become increasingly popular. According to the author's experience serum aminotransferase is raised in about 100% of cases of chronic active hepatitis and also in active cirrhosis, but in only about 70--80% of persisting hepatitis or in moderately active chronic hepatitis. They are frequently normal in inactive cirrhosis. After aminotransferases the alkaline phosphatase is of great importance for the differential diagnosis of icterus. If aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase are determined at the same time, every cholestatic icterus can be diagnosed with certainty.

Alanine Transaminase↗
PubMed1978

Pattern and concentration of free amino acids in the plasma and liver tissue of phenobarbital-treated rats.

The pattern and concentration of free amino acids in the plasma and liver tissue of phenobarbital-treated rats was investigated. In phenobarbital-treated rats, there was a significant plasma increase of the total concentration of free amino acids. No significant change in liver free amino acid concentration was observed because of the contemporaneous and general increase in liver size which does not allow observation of any percentual variation in amino acid concentration.

Amino Acids↗
PubMed1977

Free amino acids in plasma during experimental infection of mice with the MHV-3 strain of mouse hepatitis virus.

The concentrations of total free amino acids, single free amino acids, urea, and ammonia were determined in plasma of mice during experimental infection with the MHV-3 strain of mouse hepatitis virus. Analysis of free amino acids was done by ion-exchange resin chromatography under conditions that allowed the use of a single chromatographic column, separation of glutamine and asparagine, and an accelerated rate of chromatography. The results showed that as early as 6 hr after infection there was a decrease in the concentration of several free amino acids as well as in the total concentration of free amino acids in plasma. For most of the amino acids the decrease persisted until 48 hr. Only at 72 hr, during severe cytolysis, did the concentration of amino acids increase significantly. It is suggested that the decrease during the initial phases of the infection may be due to a thermolabile factor that is produced by circulating leukocytes and that effects a flow of free amino acids from the plasma toward the liver. The final increase in concentration of several free amino acids reflects the cytolytic damage to the liver caused by the virus.

Amino Acids↗