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Biomedical subjects

L Campa

Publications and source records attributed to L Campa.

8 recordsLinked to original sources
PubMed2003

Atopy and serum eosinophil cationic protein in 110 white children with vernal keratoconjunctivitis: differences between tarsal and limbal forms.

BACKGROUND: A predominance of Th2 response has been suggested in vernal keratoconjunctivitis (VKC), and a high prevalence of IgE-sensitized (IgE-S) patients has been reported (positive skin prick test or serum-specific-IgE). Palpebral and bulbar VKC are considered to be expressions of the same disease and only occasional racial and histopathological differences are described between the two forms. Tear levels of eosinophil cationic proteins have been correlated with the severity of ocular symptoms; however, there is no published study that demonstrates the presence of serum markers of disease activity. OBJECTIVE: This study was performed to evaluate the prevalence of IgE-sensitization in palpebral, bulbar and mixed VKC and to determine possible useful markers of disease activity in peripheral circulation. METHODS: A total of 110 white VKC patients (mean age 8.3 years, range 3.2-18 years) were evaluated for ocular score in the active phase of the disease. Skin prick tests and serum-specific IgE for common allergens, serum-total IgE, peripheral blood eosinophil counts (PBECs) and serum eosinophil cationic protein (s-ECP) were determined. Fifteen age-matched non-IgE-S control children underwent the same determinations. RESULTS: s-ECP, PBECs and s-total IgE were significantly higher in IgE-S than in non-IgE-S VKC patients and in non-IgE-S VKC patients than in controls. A lower prevalence of IgE-S patients was found in bulbar vs. tarsal (P = 0. 050) or mixed forms (P = 0.002). The score of giant papillae was strongly correlated with s-ECP levels (P < 0.001) and with PBECs (P = 0.001). CONCLUSIONS: Our data suggest that an overall eosinophilic response is present in VKC independently of IgE-sensitization; bulbar forms, unlike tarsal and mixed forms, were associated with a low prevalence of IgE-sensitization. Serum ECP was a useful marker of disease activity in tarsal and mixed forms.

Adolescent↗
PubMed2001

Changes in refraction in anisomyopic patients.

PURPOSE: The purpose of this study was to investigate the evolution of refraction and visual function in patients with myopic anisometropia. DESIGN: A retrospective study on a selected population. METHODS: Forty-six anisomyopic patients underwent a complete ophthalmologic examination (cycloplegic refraction, visual acuity, ocular movement and fundus examination). RESULTS: The results show two different patterns of changes in refraction between the two eyes; in the same patient, the less myopic eye tends to get more myopic, while the more ametropic eye shows a more stable refraction. Furthermore, a recovery of binocular vision and amblyopia can be obtained by occlusion and full-time refractive correction. CONCLUSIONS: The evolution of refraction seems to be different in eyes with anisometropia and it is still to be understood whether it is fixation or reduced fixation that leads to a myopic shift.

Anisometropia↗
PubMed1990

[Placoid pigment epitheliopathy: a parallel study between automatized perimetry and fluorescence angiography].

This report concerns a patient whom, on the basis of clinical data and instrumental findings, we diagnosed as suffering from Acute Multifocal Posterior Pigment Epitheliopathy (AMPPE). We found the comparison of the angiographic findings and of the automated perimetry performed with the Octopus quite interesting since the literature does not contain reports of such comparisons. The results of perimetry were also of considerable interest. The test revealed serious impairment of retinal luminous sensitivity. The comparison of angiography and automated perimetry of the lesions of the pigmented epithelium was quite useful for providing a better clinical picture and understanding of the functional state.

Adult↗
PubMed1990

[Electrophysiological studies in amblyopia].

The authors describe the methods of recording the visual evoked potentials and of their utilization for investigations in amblyopia. The characteristics of VEP have been analyzed in an amblyopic and a normal eye; analyzed further on were the reciprocal dependencies between an uniocular and binocular records, the phenomenon of suppression and sensitivity to contrast. The authors confirm the suitability of the VEP for objective evaluation of the progress of treatment and for elucidation of the physiopathology of amblyopia.

Amblyopia↗
PubMed1988

[Elevation in adduction. Relation to congenital strabismus and other types of ocular motility disorders].

This retrospective study shows the clinical data of 81 patients with elevation in adduction. The relationships between the elevation in adduction and various ocular anomalies, such as horizontal deviations, refractive errors, nystagmus, torticollis, superior oblique muscle paralysis and dissociated vertical deviation, have been studied in order to specify the clinical characteristics of this phenomenon. The age of onset of the elevation in adduction and of the dissociated vertical deviation has also been considered, and a typical temporal progression of these symptoms has been found. In this sequence, we first noticed the onset of the horizontal deviation, then the appearance of the elevation in adduction, and finally the appearance of the dissociated vertical deviation. Although the elevation in adduction is frequently found in association with the complex syndromic pattern of congenital esotropia, this phenomenon may also accompany other types of anomalies of ocular motility.

Adolescent↗