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Biomedical subjects

L Cano

Publications and source records attributed to L Cano.

13 recordsLinked to original sources
PubMed2006

A randomized trial comparing two corticosteroid regimens combined with mycophenolate mofetil and cyclosporine for prevention of acute renal allograft rejection.

INTRODUCTION: The launching of mycophenolate mofetil (MMF) has reduced the incidence of acute rejection episodes. We sought to evaluate the efficacy of decreasing the steroid dose. MATERIALS AND METHODS: This was a quasiexperimental, randomized, prospective trial. We enrolled 150 patients who received de novo renal transplantations from living or cadaveric donors, fulfilling the screening criteria. Patients were randomized to one of the following two arms: (A) MMF at a 2 g/d dose, cyclosporine (CsA) at a dose necessary to achieve target levels, and corticosteroids at the usual doses; (B) MMF at a 2 g/d dose, CsA at a dose necessary to achieve target levels, and corticosteroids at doses 50% lower than those of group A. RESULTS: Group A included 72 (48%) and group B, 78 patients (52%). There were no differences among the variables: leukopenia occurred in 11 patients in group A, and five patients in group B. Complications occurred in 67.4% (56) of group A, but only 32.6% (27) were related to infections. One case of urinary infection occurred in group B, while six occurred in group A. There was one case of acute rejection in group A, and none in group B. One graft loss occurred in group A. There were no differences in the remaining variables under study. DISCUSSION: The results showed an increased complication rate related to receiving usual steroid doses. There was no increase in acute rejection episodes among patients receiving 50% of the usual steroid dose.

Adrenal Cortex Hormones↗
PubMed2001

[Evaluation of the anatomopathological characteristics and the safety of radiofrequency lesions at the atrial level with two different systems of irrigated tip catheters on an experimental level].

INTRODUCTION AND OBJECTIVES: We performed this study to evaluate the security and efficacy in the lesions produced on the atrial wall by different irrigated catheters in an experimental model. We evaluated the anatomopathologic characteristics of the lesions produced by two different systems of irrigated tip catheters, with opened or closed circuit. METHODS: This study was performed in 16 pigs applying 60 sec radiofrequency pulses with three different energy levels (15, 25 y 50 Watts). Two different systems of radiofrequency ablation irrigated catheters were used, opened and closed. We used 4 pigs in which we performed ablation with a standard catheter as a control group. Under fluoroscopic guidance, catheters were placed on the high and low right atrial lateral wall, where lesions were produced. After 7 days, animals were sacrificed for anatomopathological study. RESULTS: A total of 27 lesions were performed with irrigated catheters (11 closed circuit and 16 opened) and 6 with standard catheters in the control group. We did not find significant differences in the lesion characteristics between the two different systems of irrigated tip catheter used, nevertheless lesions performed with the closed system were slightly greater. Th lesions produced with irrigated catheters were always superior in the control group. Transmurality in the free atrial wall is frequent with both systems. We did not see any perforation in the atrial wall. CONCLUSIONS: We did not find significant differences in the size of the lesions produced with the two systems of irrigated catheters used. These data from an experimental model can provide useful information for atrial tachycardia radiofrequency ablation procedures in humans.

Animals↗
PubMed1999

[Churg-Strauss syndrome with pericardial and myocardial involvement].

We report the case of a 63-year-old female diagnosed with Churg-Strauss syndrome with both pericardial tamponade and myocardial involvement with congestive heart failure. Allergic granulomatosis and angiitis (Churg-Strauss syndrome) is classically characterized by hypereosinophilia and systemic necrotizing vasculitis of medium and small arteries in patients with previous allergic rhinitis or bronchial asthma. Subsequently the disease has been shown to be associated with cardiac involvement and is responsible for higher morbidity and mortality. The literature for Churg-Strauss syndrome of the heart is reviewed and recent advances in the clinical management of the disease according to appropriate therapeutic strategies are recommended.

Cardiac Tamponade↗
PubMed1990

The effect of indomethacin on the pulsatility index of the umbilical artery in human fetuses.

Pulsed and continuous-wave Doppler ultrasonography was used to assess blood velocities in the ductus arteriosus and the pulsatility index of the umbilical artery in 20 fetuses (1 pair of twins and 18 singletons) at 23 to 33 weeks' gestation during maternal indomethacin therapy for preterm labor or polyhydramnios. There was no statistically significant difference in the pulsatility index of the umbilical artery during maternal indomethacin treatment (mean +/- SD, 1.11 +/- 0.20) when compared with baseline values (1.12 +/- 0.19) in all 20 fetuses studied. An increase in the peak systolic and diastolic blood velocities in the ductus arteriosus consistent with ductal constriction was noted in 9 fetuses. Analysis of the umbilical artery pulsatility index values before and during indomethacin in this subgroup of fetuses failed to reveal a statistically significant change (1.12 +/- 0.19 vs. 1.11 +/- 0.20). Indomethacin therapy does not influence the pulsatility index of the umbilical artery at the gestational ages studied.

Blood Flow Velocity↗
PubMed1988

Indomethacin in the treatment of premature labor. Effects on the fetal ductus arteriosus.

Indomethacin is a potent agent in the treatment of premature labor, but its use has been limited because of concern about its constrictive effects on the fetal ductus arteriosus. To study these effects we used serial fetal echocardiography in 13 pregnant women in premature labor who received indomethacin according to three different dose schedules, ranging from 100 to 175 mg per day, for a maximum of 72 hours. The gestational ages of the fetuses ranged from 26.5 to 31.0 weeks. The detection of ductal constriction in 7 of the 14 fetuses by echocardiography led to the discontinuation of indomethacin. Three fetuses also had tricuspid regurgitation. There was no statistically significant difference between the mean (+/- SEM) gestational age of the fetuses with ductal constriction and that of those without constriction (29.3 +/- 0.59 and 28.4 +/- 0.52, respectively). There was no relation between serum indomethacin levels in the mothers and ductal constriction. In all seven fetuses affected, ductal constriction had resolved by the time they were restudied 24 hours after the discontinuation of indomethacin. Persistent fetal circulation was not detected in any of the 11 neonates studied after delivery. Indomethacin used to treat premature labor appears to cause transient constriction of the ductus arteriosus in some fetuses, even after short-term use.

Adolescent↗
PubMed1988

Percutaneous umbilical cord blood sampling in the evaluation of fetal platelet counts in pregnant patients with autoimmune thrombocytopenia purpura.

Autoimmune thrombocytopenia purpura in pregnancy is associated with fetal thrombocytopenia. Twenty-one patients with autoimmune thrombocytopenia purpura (22 fetuses) underwent 26 umbilical cord punctures to assess the fetal platelet count. Blood could not be obtained from one fetus. Thrombocytopenia (less than 150,000/microL) was found in five cases, but in none was it of sufficient degree to preclude vaginal delivery. Persistent fetal bradycardia necessitating emergency cesarean delivery occurred in two cases. Umbilical cord puncture was found to be technically more difficult in the term fetus than in the second-trimester fetus studied in previous investigations.

Adolescent↗
PubMed1984

Gastric emptying of solid and liquid meals in healthy young subjects.

Gastric emptying was measured in 50 young healthy subjects by means of sequential scintigraphy with two radioactive markers. Gastric emptying of the solid component of the meal was slower than that of the liquid component, corresponding to a linear model (T 1/2, 112 min). Gastric emptying of the liquid component was different, following an exponential model, although only after 45 min (100% of the liquid marker retained in the stomach after 15 min, 56.7% after 45 min, 43.3% after 75 min, and 35.5% after 105 min). Significant differences were found in gastric emptying of both solids and liquids among sexes; women emptied the stomach more slowly than men regardless of age, weight, height, or body surface. A relationship was found between gastric emptying and the phase of the menstrual cycle. Furthermore, a quicker emptying of the liquid component was observed in smokers. These factors should be considered in the evaluation of gastric emptying studies.

Adult↗
PubMedDate not supplied

[Meningococcal disease in Spain: seasonal nature and recent changes].

BACKGROUND: In this study we built a time series model in the time domain based on the cases of meningococcal disease declared every four weeks in Spain between 1972 and 1998 With the model we analyzed the incidence of the disease and examined whether an epidemic really took place at the beginning of 1997, or whether the values were in the range of expectations. At this time there was widespread social alarm in Spain, because there was considered to be an outbreak of meningitis. We also examined whether the incidence of the disease diminished during 1997 following the measures introduced by the Comisión Interterritorial del Sistema Nacional de Salud. METHOD: The data on the incidence of the meningococcal disease in Spain were obtained from the Boletín Epidemiológico Semanal, published by the Instituto de Salud Carlos III, declared from 1972 to 1998 and grouped every four weeks. The method corresponds to the time series model in the domain of time: the Box-Jenkins method. RESULTS: In order to explain the behaviour of the disease during the years of the study we chose a model ARIMA(0,1,1) (0,1,1)13 that shows annual seasonal behaviour, with higher incidence in the winter and the beginning of spring, and lower incidence in summer. An intervention analysis showed that in March 1996 there was a level shift in the incidence of the illness. This lasted until September 1997, at which time the incidence returned to pre-1996. CONCLUSIONS: The measures of sanitary monitoring against the meningitis in the months of greater incidence, winter and beginning of spring must be intensified. Between spring 1996 and autumn 1997 the incidence of meningitis increased. Thereafter, until the end of 1998, there was a significant decrease in incidence, attributable to the performance of the health authorities.

Humans↗