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Biomedical subjects

L Capron

Publications and source records attributed to L Capron.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Epidemiology and risk factors of cerebral arterial accidents].

In France, available epidemiologic data (mortality statistics, Paris prospective study)--although still insufficient--indicate: 1) that arterial strokes account for about 13 per cent of all deaths, and 2) that their annual incidence in men aged 40 to 60 is around 0.6 per thousand and increases sharply thereafter. These results are comparable to those of other industrialized countries, with the exception of Japan where the actual incidence of arterial strokes seems to be higher. Age and high blood pressure are the major risk factors and causes of the various types of ischaemic and haemorrhagic arterial strokes. Several studies suggest that the treatment of hypertension significantly decreases the incidence of arterial strokes.

Adult↗
PubMed1984

Diabetes and insulin: actions and interactions upon the glucose metabolism of rat aorta.

We studied the glucose oxidation to CO2 and the incorporation of glucose into lipids by thoracic aorta from streptozotocin-diabetic rats in two circumstances: 9 minutes exposure of the isolated aorta to insulin, perfused in situ; and one-week treatment with either low--4 units (U)--or high--12 U--daily doses of insulin. Diabetes inhibited the glucose metabolism of media and adventitia. Perfusion with insulin did not influence the depressed metabolism of media but increased that of adventitia. Four units insulin treatment normalized the synthesis of glucose-derived lipids by the media, whereas 12-U treatment brought it to levels significantly higher (+23%) than those found in nondiabetic rats. We conclude that: (a) a haemodynamic explanation cannot account for the in vitro insulin resistance of media found in diabetes; (b) insulin treatment exerts a dose-dependent lipogenic effect upon the media, which might favour an atherogenic role for therapeutic hyperinsulinaemia in insulin-dependent diabetics.

Animals↗
PubMed1983

[Atherosclerosis. Description and mechanisms. Part 1: description].

This review is devoted to the cellular biology of the arterial wall, particularly of the cerebral arteries. Starting with the description of the structure and physiology of normal arteries and of atherosclerotic lesions some of the current theories on the mechanisms of atherosclerosis are considered. They have developed along two lines of thinking according to whether the main role is given to arterial smooth muscle cells or to macrophage cells. Both hypotheses view atherosclerosis as a pathological deviation from a physiological reaction aimed at maintaining and repairing the permanently strained arterial intima. The risk factors, as identified by epidemiological studies, are likely to play a major role in this degenerative process.

Arteries↗
PubMed1982

[Takayasu's disease. Diagnostic criteria (author's transl)].

Retrospective analysis of the records of 86 patients with Takayasu's disease confirmed that the condition is more common in women, that it is frequently associated with a history of tuberculosis and that angiography is of considerable help in showing vascular lesions that are characteristic by their location (common carotid artery, post-vertebral subclavian artery) and by their diffusion to various areas. Histological examination of 20 surgical specimens confirmed the diagnostic value of sclerosis of the media and adventitia (associated or not with inflammatory lesions) and therefore radically different from the lesions of the intima observed in Horton's disease. Diagnostic criteria based on clinical, radiological and histological data are proposed.

Aortic Arch Syndromes↗
PubMed1982

[Systemic scleroderma : salivary immunoglobulins and the Gougerot-Sjögren syndrome].

The concentrations of immunoglobulins (Ig) A, G and M were measured in saliva using an electro-immunodiffusion technique at pH 5 with carbamylation of the antisera. Thirty-one controls and 20 patients with generalised scleroderma (10 with and 10 without Sjögren's syndrome) were studied. The three classes of immunoglobulins were in normal saliva. A concentration of IgG greater than 55 mg/l in whole saliva was associated with Sjörgren's syndrome. This is the consequence of the reduction of the rate of saliva production, as well as an increased local synthesis of IgG. The measurement of IgG in unconcentrated saliva could be useful in the detection of Sjögren's syndrome.

Humans↗