A fibrin clot stops low density lipoprotein apheresis.
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Blood Coagulation↗
Biomedical subjects
L Cattin
Publications and source records attributed to L Cattin.
[Dyslipidemia and reduced fibrinolysis in a child with hemolytic-uremic syndrome].
Many pathogenetic factors may enhance coagulation process and induce thrombosis. The Authors report a case of hemolytic-uremic syndrome, with marked evidence of macroscopic kidney thrombotic involvement, in which an important dyslipidemia (hypertriglyceridemia and hypercholesterolemia) was detected during the phase of clinical improvement. These findings, and the contemporary marked reduction of fibrinolytic activity, seem to be relevant pathogenetic factors in this case. The treatment with polyunsaturated fatty acids Omega 3 may have been helpful in modifying these serum abnormalities and maybe could have brought to the clinical improvement.
Blood Coagulation Disorders↗
Low density lipoprotein-apheresis decreases oxidized low density lipoproteins and monocyte adhesion to endothelial cells.
The mutual interaction between monocytes and low density lipoprotein (LDL) in atherogenesis prompted a test of the hypothesis that LDL-apheresis could reduce the adhesive properties of monocytes to endothelium; and therefore interfere with a key mechanism in atheroma formation. Five patients affected by heterozygous familial hypercholesterolemia were studied. All patients received LDL-apheresis treatment with selective adsorption of LDL-cholesterol on dextran-sulphate columns. Low density lipoprotein particles were isolated by sequential preparative ultracentrifugation and subfractionated by ion exchange high performance liquid chromatography. Thiobarbituric acid reacting products of lipid peroxidation were measured fluorometrically. Vitamin E was estimated by high performance liquid chromatographic technique. Monocytes were isolated from patients blood before and 1 day after LDL-apheresis by Percoll gradient. The blood samples for monocyte adhesion were drawn from control subjects for 2 consecutive days. The adhesion of monocytes to an endothelial monolayer was evaluated by assaying the peroxidase content of the adherent monocytes. Low density lipoprotein-apheresis reduced total cholesterol (-65%; p < 0.01), LDL-cholesterol (-75%; p < 0.01), triglycerides (-51%; p < 0.05), and fibrinogen (-28%; p < 0.01). With LDL-apheresis treatment, a reduction of 54% in oxidized LDLs was observed; vitamin E concentration significantly increased in LDLs (+ 14.2%; p < 0.05). The monocyte adhesion decreased by approximately 61% after apheresis; the variation became statistically significant (-65%; p < 0.01) when endothelial cells were stimulated by lipopolysaccaride.
Aged↗
[Blood sugar control in children and young diabetics during an educational summer camp].
UNLABELLED: The aim of the study was to evaluate the impact of educative summer camp on the glycemic control in two different age-groups of young diabetic patients. METHODS: 54 patients (36 M, 18 F, age 10-27 years, duration of diabetes 2-19 years), treated with 0.81 +/- 0.2 UI/kg/day of insulin and with HbA1c mean levels of 8.25 +/- 1.35 g% were followed by an equip of 8 medical doctors, 4 nurses and 1 dietician for a week during an educative summer camp. RESULTS: 34 children, group 1 (20 M, 14 F, 10-14 years aged, mean duration of the disease 4.52 years, range 2-12 years) and 20 young adults, group 2 (16 M, 4 F, age 16-27 years, mean duration 10.21 years, range 2-19 years) were evaluated. Insulin doses and HbA1c levels were 0.82 +/- 0.21 UI/kg/day vs 0.80 +/- 0.22 U/kg/day and 9.54 +/- 1.5% vs 7.6 +/- 0.6%, p < 0.02 in group 1 and 2 respectively. Glycemic levels at 8 a.m. and 11 p.m. were significantly higher in group 1 than in group 2 (180 +/- 87 mg% vs 219 +/- 77 mg%, p < 0.05 and 164 +/- 84 mg% vs 201 +/- 81 mg%, p < 0.05). Hypoglycemic/patient/episodes were 1.82 vs 0.72, p < 0.05 in group 1 and group 2 respectively. CONCLUSIONS: 1. Glycemic control was unsatisfactory in both groups and it was significantly worse in the group of youngs, though in this group HbA1c level was significantly lower. 2. The risk of hypoglycemia was significantly higher in group 1, though in this group insulin doses were significantly decreased.
Adolescent↗