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L Cebecauer

Publications and source records attributed to L Cebecauer.

At least 37 records · Page 2Linked to original sources
PubMed1980

Antibodies to natural double-stranded RNA and to synthetic polyribonucleotides in the sera of patients with systemic lupus erythematosus.

A parallel testing of antibodies to double-stranded ribonucleic acid in 80 sera from patients with systemic lupus erythematosus by the membrane binding method using natural 3H-dsRNA preparation and synthetic 125I-poly I. poly C preparation revealed a good correlation (r = +0.81). In a selected set of patients with SLE we observed a slight tendency to preferential binding of the natural preparation and a lower frequency of anti-dsRNA antibodies when compared to that reported by other investigators. The presence of anti-dsRNA did not correlate with the presence of anti-dsDNA.

Antibodies↗
PubMed1979

Monoclonal immunoglobulinaemia in rheumatological practice.

Monoclonal immunoglobulinaemia is the manifestation of a number of diseases with a quite different prognosis. In some instances in can be associated with articular symptomatology. The authors present an analysis of case-records of four patients where monoclonal immunoglobulinaemia was associated with signs of rheumatic disease--oligoarthritis or polyarthritis of the rheumatoid type. In one instance Waldenström's macroglobulinaemia with Sjögren's syndrome and hyperviscosity syndrome was involved. In another patient a myeloma was diagnosed. In the remaining two patients a more benign type of monoclonal immunoglobulinaemia was involved.

Adult↗
PubMed1979

Clinical importance of antibodies against double-stranded ribonucleic acid in systemic lupus erythematosus and similar diseases of connective tissue.

Prolonged repeated analyses of sera from 98 patients with systemic lupus erythematosus (SLE) and 76 patients with similar diffuse diseases of connective tissue by a radioisotope membrane binding method for the assessment of antibodies against double-stranded ribonucleic acid (anti-ds-RNA) revealed that these antibodies are most frequently encountered in patients with the evolutive form of SLE (53%), but also in approximately one fifth of patients with non- evolutive SLE and in patients with similar diffuse diseases of connective tissue. Anti-ds-RNA are not linked with stages of clinical activity; their occurrence is on the whole independent on the occurence of antibodies against ds-DNA and nuclear ribonucleoprotein. There is a very close association with the incidence of antibodies against denatured DNA and a substantially small association with antibodies against acid nuclear antigen (Sm). The occurrence of anti-ds-RNA is a favourable prognostic sign, as in the majority of patients who had such antibodies at any time in their serum, later the disease can be suppressed by treatment, while patients who never had anti-ds-RNA in serum remain for a long time in the active stage of the disease.

Autoantibodies↗
PubMed1977

DNA polymerase activity and antibody against it in sera of patients with systemic lupus erythematosus.

In the sera of one half of patients with sytemic lupus erythematosus (SLE) the endogenous and exogenous DNA polymerase activities were observed. The simultaneous presence of DNA polymerase activity and the antibodies to denatured DNA in the half of polymerase positive SLE sera was proved. The polymerase activity was not associated with virus-like particles. The endogenous polymerase activity probably used RNA, the exogenous one prefered DNA as a template. The determination of template requirement was complicated by the complexity of SLE sera. The product of polymerase activities were DNA-RNA hybrid and DNA. In some sera of the SLE patients without polymerase activity the antibodies against the polymerase were found. The occurrence of DNA polymerase activity and possible viral origin of SLE was discussed.

Antibodies↗
PubMed1976

[The value of urinary enzyme determinations in systemic lupus erythematosus (author's transl)].

During a period of 4 years urine samples from 54 patients with systemic lupus erythematosus (SLE) were repeatedly analysed for the activities of lactate dehydrogenase (LDH), leucine aminopeptidase (LAP) and alanine aminopeptidase (AAP). Increased urinary enzyme levels were consistently found in 8 patients with severe lupus nephritis and the nephrotic syndrome, as well as in 9 patients with chronic lupus nephritis resistant to therapy. A further group of 9 patients with lupus nephritis responded favourably to immunosuppressive therapy with arrest of kidney-damaging processes; a concomitant normalization of urinary enzyme levels was observed, giving an accurate reflection of the progression of the disease. Another 14 SLE patients showed raised enzyme levels preceding the development of clinical signs of nephropathy. The last 14 SLE patients displayed neither nephropathy nor altered enzyme activities. The determination of urinary enzyme activities is, therefore, considered to be a useful supplement to the routine biochemical analyses performed on the urine in cases of SLE.

Alanine↗
PubMed1976

Influence of thymosterin on immunological reactivity in New Zealand mice.

The influence of thymosterin on immunological reactivity of NZB mice was investigated. Thymosterin was administered three times per week for a period of six weeks to male and female NZB mice. Only lymphocytes from untreated female mice gave the positive results in the macrophage migration inhibition test using native DNA as the stimulating antigen. This effect was suppressed in thymosterin treated females. The administration of thymosterin therefore appears to correct the in vitro delayed hypersensitivity to DNA antigen.

Animals↗