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Biomedical subjects

L Censi

Publications and source records attributed to L Censi.

7 recordsLinked to original sources

[Hypertension in schoolchildren: research carried out in a secondary school in Rome and observations on dietary patterns].

AIM: The aim of this research was to evaluate the incidence of hypertension in adolescents by assessing their anthropometric measurements and diet, since recent literature data suggest that 30% of obese adolescents are hypertensive. METHODS: The 293 schoolchildren engaged in the study were aged 11-14 years and 54% were male. They attended a Secondary School in Rome with a middle-high class background. Blood pressure, heart rate, weight, height, tricipital and subscapular skinfolds and body mass index (BMI) were measured and dietary patterns assessed through 24-h recall. The findings were then statistically evaluated. RESULTS: The incidence of hypertension was 6.5%, without distinction between sexes. On the basis of the statistical evaluation of the correlations between hypertension and obesity, familial hypertension, weaning with the addition of salt and bottle-feeding from birth, only obesity was found to be statistically significant (p<0.001). Even though the hypertensive adolescents had a high intake of snacks, salt, meat, sausages and cheese in their daily diet, only the excess of proteins was statistically significant (p<0.05). The incidence of obesity (calculated as being 20% over the ideal weight for a given height) was 17.3%. This finding was confirmed by the mean value of the both skinfolds, whereas BMI, for which obesity and overweight were considered together, showed a slight overestimation of this percentage. CONCLUSION: A high number of hypertensive adolescents was found, about 1/3 of the obese adolescents examined. This confirms the findings of an extensive study previously carried out by the Group of Hypertension of the Italian Society of Pediatrics. From a nutritional point of view, the excessive intake of proteins of the 19 hypertensive adolescents was found to be statistically significant. However, a more extensive study could probably provide further data on other nutrients which, in this case, were not quite statistically significant.

Adolescent↗

Basal metabolic rate in anorexia nervosa: relation to body composition and leptin concentrations.

BACKGROUND: Leptin is thought to represent a peripheral signal involved in the regulation of energy balance. Its action has been studied in animals and obese subjects. Little is known about leptin's role during negative energy balance. OBJECTIVE: The objective was to evaluate the relation between energy turnover, body composition, and plasma leptin concentrations in anorexia nervosa (AN). DESIGN: Sixteen weight-stable women with AN were compared with 22 control subjects and 14 rehabilitated AN patients (R-AN). Basal metabolic rate (BMR) was measured by indirect calorimetry; fat-free mass (FFM) and fat mass (FM) were calculated according to a 4-compartment model. Plasma leptin was determined by radioimmunoassay. RESULTS: The BMR of AN patients (2.73 +/- 0.37 kJ/min) was significantly lower than that of control subjects (3.45 +/- 0.34 kJ/min) (P < 0.001), even after adjustment for FFM (2.92 +/- 0.33 kJ/min in AN patients and 3.30 +/- 0.26 kJ/min in control subjects; P < 0.004). Plasma leptin concentrations in AN patients were 76% lower than in control subjects, even after body fat was controlled for. In R-AN patients, BMR was not significantly different from that of control subjects and leptin concentrations were generally close to normal. Plasma leptin concentrations correlated significantly with FM (r(2) = 0.53, P < 0.0000) and BMR, even after adjustment for FFM (r(2) = 0.21, P < 0.0003). CONCLUSIONS: BMR and plasma leptin concentrations are depressed in patients with AN; this is not explained by body-composition changes. The relation between leptin and BMR suggests that leptin plays a role in the energy sparing response to exposure to chronic energy deficiency. The return of BMR to normal and the significant increase in leptin concentrations in R-AN patients suggests a full reversibility of this adaptation mechanism.

Adolescent↗

The basal metabolic rate and energy cost of standardised walking of short and tall men.

OBJECTIVES: To assess the influence of stature on the basal metabolic rate (BMR) and on the energy cost of standardised walking. A second objective was assess the accuracy of the FAO/UNU/WHO (1985) equations to predict BMR. DESIGN/SUBJECTS: Forty-six young men were selected on the basis of their stature and assigned to the group of short, S (n = 25, mean stature = 1.65 +/- 0.03 m) or of tall, T (n = 21, mean stature = 1.87 +/- 0.04 m). SETTING: Rome, Italy. INTERVENTIONS: Body composition was assessed by underwater weighing. BMR and energy cost walking at 5 km/h was measured by the Douglas bag. RESULTS: Body fat % was similar in the two groups (15.2 +/- 4.3 for S; 17.4 +/- 5.3 for T; ns). The BMR of T was 20% higher than that of S, but 12% and 10% lower when standardised respectively for body weight (BW) and fat free mass (FFM). However these differences were removed when BMR was covaried for BW or FFM, or normalised by BW0.62 or FFM0.64. Measured BMR was 7% for T and 6% for S lower than that predicted by the FAO/WHO/UNU (1985) equation; the inclusion of stature did not reduce the overestimation. The energy cost of walking was 27% higher in T than in S, but 9% and 5% lower when standardised respectively for BW and FFM. The differences disappeared when expressing the energy cost of walking as net cost per kg FFM. CONCLUSIONS: Tall people have lower BMR per unit of BW or FFM than short people, and it is necessary to control for the diverse body mass by the appropriate method. However, qualitative differences in the composition of FFM are plausible, due to the diverse proportion of metabolically active internal organs in people of different height, which might be reflected in the higher BMR/kg FFM of the shorter subjects. The sex- and age-specific FAO/WHO/UNU (1985) equation significantly overestimates the BMR of both short and tall people, but there is no simple explanation of this observation. The energy cost of walking is not affected by stature when expressed as net cost per kg FFM.

Adipose Tissue↗

Body composition changes in anorexia nervosa.

OBJECTIVE: To assess the body composition changes in anorexia nervosa and after medium term recovery. DESIGN: A descriptive study. SETTING: Rome, Italy. SUBJECTS: Twenty women affected by anorexia nervosa (AN) with a BMI [weight (kg)/height (m2)] below 17 kg/m2 and weight-stable for at least three months, were compared with 10 well nourished control women (CO) and nine rehabilitated subjects (R-AN), who had a BMI above 18.5 kg/m2 stable for at least the last six months. INTERVENTIONS: Body fat was assessed by underwater weighing, muscle mass by urinary creatinine, total body water (TBW) by impedance parameters (50 kHz and 800 microA), skeletal mass by anthropometry and radius bone mineral density by dual photon absorptiometry in ultra-distal (UD-BMD) and medio-distal (MD-BMD) sites. RESULTS: The AN group, as compared to the control group, had a significantly lower weight, body mass index (BMI kg/m2) and percent body fat (P < 0.0000). Creatinine urinary excretion was lowest in absolute term and when expressed as creatinine height index or per kg fat free mass (FFM) (P < 0.0000); muscle mass per kg body weight was 13% lower (P < 0.01). Ultra distal bone mineral density (UD-BMD) was 6% lower (not significant). TBW as percent of body weight was significant higher (P < 0.001): however TBW/FFM % was not statistically different with large inter-individual variability. An altered distribution of extra and intra-cellular water was suggested by the phase angle (AN: 4.4+/-0.8 degrees; CO: 6.1+/-0.4 degrees; (P < 0.0000). In rehabilitated anorexic patients (R-AN) the fat mass represented 53% of the weight gain. Their creatinine excretion remained still below the mean value of the controls (P < 0.001). The impedance parameters were not significantly different between the R-AN and the CO groups, however, the phase angle of the R-AN (5.0+/-0.7 degrees) remained lower than in the CO group, indicating that the water distribution was still altered. CONCLUSIONS: This study shows that AN is a condition of reduced body fat as well as of muscle mass, with a slightly reduced bone mass. In the course of rehabilitation, most of the weight regained is represented by fat, while the muscle mass appears to lag behind, at least in the medium term.

Adipose Tissue↗

Intra- and interobserver concordance in scoring Harris lines: a test on bone sections and radiographs.

Little attention has been devoted to assessing the reproducibility of (paleo) pathological observations. Harris lines (HL) are among the markers most used to determine chronology of stresses suffered during growth. Nevertheless, their scoring entails remarkable methodological difficulty. Bone sections (S) and radiographs (R) of 29 adult tibiae of archeological provenance (medieval) were scored for HL by five observers. At regular intervals of time, each observer gave two independent counts on both series. Results show a) a substantial interobserver disagreement of HL estimates for both sectional and radiographic records, and b) a high level of intraobserver error.

Adult↗

[Mini Nutritional Assessment (MNA) and nutritional risk in elderly. A proposal of nutritional surveillance system for the Department of Public Health].

Objective of the study is to present an intervention model to evaluate nutritional risk of institutionalised elderly, suitably with the aims and resources of the Hygiene of Nutrition Services, and to individuate predictive variables of nutritional vulnerability. 237 subjects from the residential homes of ASL RMB were involved in the study; to each subject was administered: a) the Mini Nutritional Assessment (MNA); b) a questionnaire for the analysis of the risk factors. Multivariate logistic regression analysis was performed to evaluate the influence of the risk factors on nutritional status. On the basis of BMI the prevalence of malnutrition is 6.5% and the prevalence of overweight and obesity is respectively 41.6% and 22.9%; on the basis of MNA, 5.1% of the subjects is malnourished and 60.3% at risk for malnutrition. The absence of chewing difficulties (OR 2.94; I.C. 1.46-5.91) and the habit to eat all foods served at meals (OR 2.83; I.C. 1.46-5.91) are associated with a good nutritional status. The age > or = 90 years is a risk factor for malnutrition at the limit of statistical significance (OR 0.44; I.C. 0.14-1.00). Carrying out the MNA resulted easy and quick, confirming the hypothesis for feasibility of this protocol in the Hygiene of Nutrition Services. The results highlight an high nutritional risk of the elderly nursing home residents and the importance of planning programs of nutritional surveillance with particular attention on masticatory function impairments, meal intake and on the oldest subjects among the elderly as a group greatly vulnerable. We believe that these areas are very important in defining public health intervention programs.

Aged↗