Drug-induced renal stones: incidence, clinical expression and stone analysis.
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Biomedical subjects
Publications and source records attributed to L Cifuentes-Delatte.
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An apatite containing citrate ions has been synthesized. Measurements of specific surface, as well as Ca/P ratio, infrared, X-ray, and calcination data are all consistent with the idea that citrate ion substitutes for PO4(3-) ion on the apatitic surface.
We recently described a new component of calculi, trimagnesium orthophosphate. In a microscopical study of thin sections from 3500 urinary calculi we detected this compound in 14 stones, all of which contained struvite. New data suggest that trimagnesium orthophosphate is a transformation product of struvite. This well-crystallized substance was always detected a few days after the surgical extraction of struvite kidney stones, in contrast to the newberyite that appears on the surface of very old removed stones or after long exposure of stones to the atmosphere.
52 patients with advanced bladder cancer, no longer controlled by conventional therapy, have been treated by combination chemotherapy with Adriamycin and 5-fluorouracil. The objective remission rate has been 40%. The morbidity of the chemotherapy has not been excessive. The response has not been related to the histological grade of the primary tumour and previous treatment. Patients with a good performance status (Karnofsky index) have responded better than those with a poor performance status.
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