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Biomedical subjects

L Cima

Publications and source records attributed to L Cima.

At least 55 records · Page 3Linked to original sources
PubMed1983

Severe acute poisoning from the ingestion of a permanent wave solution of mercuric chloride.

1 A woman developed severe mercury intoxication from ingestion of about 2.5 g of mercuric chloride. 2 Antidotal treatment with a dithiol (BAL i.m.) and a monothiol (tiopronin i.v.) was started promptly. 3 Dialysis treatment thereafter markedly increased the elimination of mercury, thus hastening recovery. 4 It is suggested that chelating agents associated with dialysis are an effective treatment for mercury poisoning.

Dimercaprol↗
PubMed1981

[Cases of acute poisoning hospitalized in the Veneto region. Preliminary results in 1721 cases].

An epidemiological study has been made of acute poisoning cases hospitalised in the Veneto region in 1978 and 1979 and the present paper reports an initial sizeable group of 1721 cases. Young people are most affected (60% of cases below the age of 30), particularly in the first decade of life. The male sex is mainly involved in poisoning due to voluntary substances (alcohol, heroin) while females are most affected by psychoactive drugs. The commonest toxic substances are: psychoactive drugs (26%), alcohol (20%), domestic products (19%), heroin (10%), non-narcotic analgesics (4%), agricultural products (3%) and cardiovascular drugs (2%). In 3% of cases it proved impossible to identify the compound in question and in 13% of poisonings different drugs and substances were involved. The average duration of admission was 41/2 days and support treatment was carried out regularly. Mortality was 0.4% (7 cases), 4 of them due to poisoning by domestic products.

Adolescent↗
PubMed1981

Record of hospitalized acute intoxication cases: a proposed statistical-epidemiological form.

A form is presented for recording acute toxicological case histories for statistical purposes. It includes personal data, case history, social and environmental data, characteristics of the poison(s), history of the intoxication, general and prevailing signs and symptoms, criteria of diagnosis, emergency measures, specific and antagonistic treatment before and during hospitalization, clinical laboratory findings, toxicological analysis, and progression of symptoms until full or partial recovery or death. This form was developed in the course of retrospective research, and can be used either for telephone emergency calls or as a part of the clinical file. Through the elaboration of the compiled forms a strict cooperation between the assisting services and the Specialized Toxicology Centre may allow for better preventive and therapeutic measures.

Acute Disease↗
PubMed1981

Sample research of hospitalized acute intoxication cases using an epidemiological form.

A form for recording acute toxicological cases has been preliminarily applied to a sample of 436 subjects admitted during 1978 into the hospitals of two districts of the Venetian Region. One was predominately manufacture and industry, and the other a mountain-agricultural area. The latter had medical facilities less uniformly distributed. Through epidemiological analysis, the acute poisoning cases from psychoactive drugs (benzodiazepines, barbiturates, antipsychotic agents, and tricyclic antidepressants) prevailed (37.9%). They were followed by acute cases from street heroin or other opiates in addicts (25.7%) that only occurred in the main town of the more industrialized district. The incidence of the other poisoning cases were in the following decreasing order: household poisons (9.8%), nonnarcotic analgesics (5.1%), agricultural poisons (4.1%), cardiovascular drugs (3.7%), miscellaneous drugs (1.4%), food and plants (1.4%), oral contraceptives (1.0%), viper envenomization (0.7%), and insect bites (0.7%). A rate of 8.5% was due to unidentified compounds. Mortality was 0.9% and death occurred after exposure to corrosives, carbon monoxide, or undetermined substances. Between the two districts there were no marked differences in emergency and general measures that mainly consisted in supportive treatment with forced diuresis (13.9%) and gastric lavage (only 21.4%).

Adolescent↗
PubMed1980

[Burkitt's lymphoma with leukemic evolution].

An account of the clinical, histopathological and aetiopathogenetic aspects of Burkitt's lymphoma is followed by the presentation of a personal case, in which the typical clinical picture of the African form progressed to terminal leukaemia. The aetiological and pathogenetic rôle of the Epstein-Barr virus is also briefly discussed.

Burkitt Lymphoma↗
PubMed1979

Some cases of acute intoxications from compulsive use of isoaminile.

Isoaminile (Peracon) has found in Italy a certain success as a substitute for hard narcotcis. Three observations are reported in which five young adults have been intoxicated by the i.v. administration of the cough suppressant. On the basis of two opposed points of view suggested by the Literature to explain the compulsive abuse of this drug, the A. have studied its physical dependence capacity by using an original technique. The isoaminile cyanide release has been measured too. The experimental results demonstrate that isoaminile does not determine a physical dependence; a slight CN- release activity occurs in vivo only with high doses.

Acetonitriles↗
PubMed1979

Synthetic enkephalins. Addicting properties and conformational studies in solution.

The addicting properties of [Leu5]enkephalin in mice are conserved in the LSer3 analogue and lost both in the L-Ser2 analogue and in all the L-Cha4 derivatives of the above peptides. Fluorescence measurements in water show the presence of hydrogen-bonded tyrosul OH groups in [Leu5]-enkephalin and in its LSer2 analogue. The Phe4/Cha replacements do not influence these equilibria, but they affect the near u.v. dichroism of the hydrogen bonded tyrosyl residues. In the peptide absorption region in water solution, only [Leu5]-enkephalin and its cyclohexylalnyl derivative show a positive dichroism towards high frequencies, which is maintained in 8 M ura. No clear relation is found between conformation(s) in solution and biological activity. A II' beta-turn, with residues in positions 2 and 3 at the corners, is suggested for the conformation of enkephalin bound to the receptors involved in the bioassay here used.

Amino Acid Sequence↗
PubMed1978

Multiple forms with glucose 6-phosphate dehydrogenase activity in Musca domestica L. as revealed by electrophoresis on cellulose acetate gel.

Single newly emerged males of Musca domestica, WHO strain, usually show five electrophoretic bands of glucose 6-phosphate dehydrogenase (G6PD) activity. Of these five molecular forms, designated with Roman numerals in order from the origin, we have considered the first three: these have been characterized with respect to their substrate and coenzyme specificity and to their sensitivity to some sulfhydryl inhibitors. The data show band III to be G6P specific, nicotinamide adenine dinucleotide phosphate dependent and to be a type I enzyme according to Kamada and Hori's classification. Bands I and II, on the other hand, show wide substrate specificity and low sensitivity to the sulfhydryl inhibitors assayed. In addition, in the absence of an exogenous substrate and in the presence of nicotinamide adenine dinucleotide as a coenzyme, fairly weak bands, which can be ascribed to the so called "nothing dehydrogenase" effect, are seen in the position I and II. Nevertheless, the data reported do not allow a clear definition of the enzymatic type corresponding to bands I and II of G6PD activity.

Animals↗
PubMed1978

The in vitro conversion of a specific molecular form of glucose 6-phosphate dehydrogenase from Musca domestica L.

A nicotinamide adenine dinucleotide phosphate dependent glucose 6-phosphate dehydrogenase (G6PD), belonging to type I of Kamada and Hori's classification, is present on the zymograms of newly emerged males of Musca domestica. It is capable of undergoing tryptic degradation and being thus transformed into a different active enzymatic form, with some of its catalytic properties unchanged, but with different electrophoretic mobility. We show in this paper that this specific G6PD form of gut origin in M. domestica is not a tissue-specific enzyme, but rather a product of hydrolytic degradation by gut proteinases which act during the process of homogenization. Besides, the G6PD of type I in the housefly is shown to be sensitive to the "storage effect" and to protection by mercaptoethanol, contrary to its hydrolytic gut form which is not sensitive to these processes. In this connection, we discuss the possible reasons for these differences in behavior.

Animals↗