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Biomedical subjects

L Collier

Publications and source records attributed to L Collier.

7 recordsLinked to original sources
PubMed1994

Comparison of intramuscular versus subcutaneous erythropoietin for the treatment of anemia in CAPD patients.

Recombinant human erythropoietin (rHuEpo) can be administered to continuous ambulatory peritoneal dialysis (CAPD) patients subcutaneously (SC), intravenously (IV), and intraperitoneally (IP). Subcutaneous rHuEpo is preferred in CAPD patients because of its ease of administration and favorable pharmacokinetics. The longer half-life of SC rHuEpo allows for one or two doses per week. Since SC rHuEpo can cause pain and local irritation at the injection site, the efficacy and safety of intramuscular (IM) rHuEpo were compared to SC rHuEpo in 6 random stable CAPD patients. The protocol in each subject consisted of a single weekly injection of IM rHuEpo for 3-6 months (period 1), crossover to SC rHuEpo for 3-6 months (period 2), and crossover to IM rHuEpo for 3-6 months (period 3). The rHuEpo dose was adjusted by protocol to achieve a target hematocrit of 30%-33%. Pain at the injection site was graded on a scale of 0-3. All patients preferred IM rHuEpo to SC rHuEpo because of less pain at the injection site. One patient tolerated IM rHuEpo for six months (period 1), then left the study after one month of SC rHuEpo because of ecchymoses and pain at the SC injection sites. In all patients, there was no significant difference in the dose of rHuEpo (U/kg/wk) during the three study periods.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

Transvestites' women revisited: a nonpatient sample.

Data obtained from seven female partners of nonpatient transvestites are presented. None were receiving psychiatric treatment. The group was self-assembled and affiliated with a cross-dressing social organization. The sample was divided into Acceptors and Rejectors based on the degree of acceptance of their mate's cross-dressing activities. Mean relationship duration was 9.9 years. None were traumatized by accidental discovery of their mate's transvestism. Childhood loss of parent(s), substance abuse, and divorce were rare. None had had homosexual experiences. Four of seven transvestite mates were reported by their partners to have gender dysphoric symptoms at some point in their lives. All of the couples' children (two male, three female) knew of their father's transvestism by direct observation at young ages; sons from two different families were noted to cross-dress spontaneously.

Adult↗
PubMed1982

Other immunizations.

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Communicable Disease Control↗