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Biomedical subjects

L Colombi Zinelli

Publications and source records attributed to L Colombi Zinelli.

5 recordsLinked to original sources
PubMed1985

A pharmacokinetic study on midazolam in compensated liver cirrhosis.

The authors studied the pharmacokinetic behaviour of a new benzodiazepine, midazolam, after a single oral administration in a group of five patients of both sexes, suffering from compensated alcoholic cirrhosis. In this clinical situation both absorption and metabolism rates of the compound were similar to those observed in healthy subjects. The only notable effect, occurring in one severely affected cirrhotic, consisting of prolonged pharmacological activity of the drug.

Aged↗
PubMed1984

Pharmacokinetics in the elderly.

The article discusses how and why drug responses are altered in elderly patients. It describes how the mutation of body composition and decay of physiological functions in the aged alters the pharmacokinetic parameters and consequently the drug responses. It also provides guidelines on which to base estimates of an accurate drug schedule.

Absorption↗
PubMed1984

Antimuscarinic compounds and gastric kinetics: a study with pirenzepine on healthy subjects.

A study has been made on the modifications that appear after acute dosage of pirenzepine in a series of eight healthy subjects of both sexes who had shown, by radioisotopic evaluation, a physiological pattern of gastric kinetics. The acute dosage of the drug was continued for three days at therapeutic doses and, a few hours after the last administration, the same study was repeated. As a test meal, a whole fried egg containing 99mTc-labelled serum albumin was used. The kinetics of the gastric content was scanned by a gamma-camera. The difference in gastric kinetics between the baseline situation and that after administration of the drug is reported and discussed.

Adult↗
PubMedDate not supplied

A study of gastric kinetics (comparison between different isotope carriers).

From the various investigations of gastric emptying described in the literature, radionuclide labelling of meals appears to provide the most suitable technique. The emptying patterns of different 99mTc-DTPA carriers were studied in healthy volunteers, compared with patterns found after ingestion of a fried egg incorporating 99mTc-serum albumin. The results are described and discussed. They seen to suggest that there are different modalities of gastric emptying when different meals and markers are used.

Adult↗