Biomedical subjects
Publications and source records attributed to L Conde-Salazar.
An unusual cutaneous eruption of the feet and lower limbs induced by ultraviolet radiation in a 30-year-old caucasian man is presented. Previous reports in the literature and the present case indicate that sunlight and UV radiation may provoke fixed eruptions themselves without drug exposure.
BACKGROUND: Rubber additives, mainly vulcanizers and antioxidants, are increasingly a cause of contact dermatitis. OBJECTIVE: The aim of the present study was to determine the frequency of type IV allergy to rubber additives. METHODS: Seven thousand patients seen during a 10-year period were evaluated. Of them, 4680 were patch tested with the standard series recommended by the Spanish Group for Research of Contact Dermatitis (GEIDC) and a series of individual rubber additives. RESULTS: A total of 686 patients (14.7% of those patch tested) had one or more positive reactions to rubber additives. Of these, 582 (84.8%) were men and 104 (15.2%) were women. The incidence of rubber sensitization was especially high among construction workers (47.0%). CONCLUSION: Rubber additives are a common cause of occupational contact dermatitis, particularly in construction workers. We postulate that rubber gloves and boots (utilized to avoid contact with sensitizing substances) themselves may be a common cause of contact dermatitis. The high incidence of allergy to some rubber additives, such as thiurams and carbas, indicates that their replacement by other less sensitizing vulcanizers is advisable.
The incidence of rubber sensitization is difficult to evaluate, as the statistics are not standardized. Rubber gloves are considered to be the main source, but other objects are also of importance. Sensitizations are usually multiple, with the patient reactive with two or more rubber allergens. These allergens produce a great variety of clinical pictures, which are described in detail with the possible allergens implicated.
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230 patients with occupational dermatitis in the metallurgic industry were studied with standard patch test (GEIDC) and an oil series. An occupational and clinical questionnaire survey was carried out. Responses to paraphenylenediamine, chrome, cobalt in the standard series, and benzisothiazolone, triethanolamine, and Grotan BK were the main positive results.
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A revision of the sensitivities produced by PTBP resin is made, taking into account professional and consumers points of view. Fifteen cases of sensitivity to the resin are reported.
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Five carpenters in a television set factory had allergic contact dermatitis of the hands, forearms and neck after contact with the sawdust of the Brazilian rosewood substitute Machaerium scleroxylon Tul. (Pao ferro). Patch tests with R-3,4-dimethoxydalbergione from Pao ferro and with two other dalbergiones from rosewood species were positive. R-3,4-dimethoxydalbergione isolated from the Pao ferro sample was shown to be a strong sensitizer and thus to be responsible for these cases of contact allergy.
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