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Biomedical subjects

L Corina

Publications and source records attributed to L Corina.

12 recordsLinked to original sources
PubMed2003

Use of titanium mesh in comminuted fractures of frontal sinus anterior wall.

The personal experience with the surgical treatment of reduction and fixation of comminuted fractures of the anterior wall of the frontal sinus is reported. Cosmetic results were examined with regard to patients' degree of satisfaction on a 0 to 2 scale and nasal function assessed via rhinoscopy and nasal endoscopy during clinical follow-up, in the course of which the integrity and functionality of the supraorbitary and facial nerves were evaluated. All patients were satisfied, on the whole, with the aesthetic result, with 0-degree satisfaction (no deformity compared with their condition prior to the injury). The operations were performed between the 2nd and 7th post-injury day. The importance of the preoperative clinico-radiological work-up is stressed, with particular regard to the detection of simultaneous involvement of the inferior and/or posterior wall, and to the choice of surgical approach. The evolution of the surgical techniques in the treatment of frontal sinus fractures is discussed. With reference to the new means of fixation, in cases of comminuted fractures of the anterior wall, titanium mesh is preferred. In the Authors' opinion it combines excellent fixation with easy adaptability (cosmetic results are good) without requiring in the majority of cases, autologous bone grafts.

Adult↗
PubMed2003

Midfacial fractures: our experience.

Authors report their experience in the treatment of midfacial fractures in 201 patients, 177 of whom underwent surgery for reduction and fixation of the fracture. Since no functional or aesthetic deficits were present, surgery was not performed in the remaining 24 cases. Of the 177 patients, the maxillary complex was involved in 70 (classified as central and centro-lateral fractures), the zygomatic-maxillary-orbital complex in another 70, isolated fractures of the orbital floor blow-out in 18, and, isolated fractures of the zygomatic arch in 19. The results obtained and the degree of satisfaction were evaluated in 90 patients with clinical visits, as well as by telephone interview. A total of 88 patients expressed complete satisfaction with the results of the surgical outcome, while the remaining 2 patients were not satisfied with the aesthetic outcome. All patients were operated within 24-48 hours post-trauma in the case of incarceration of extrinsic ocular muscles, and within 10 days in other types of trauma, even in those patients in intensive care. The importance of clinical and radiological pre-operative diagnosis is stressed as well as the choice of the most suitable therapeutic approach for the different types of fractures, considering recent tendencies towards minimally invasive procedures to achieve better cosmetic results. The latest developments in fixation techniques with reference to titanium mini- and/or micro-plates that may eventually be substituted with absorbable materials are discussed.

Facial Injuries↗
PubMed2003

Correlation between fine needle aspiration biopsy and histologic findings in parotid masses. Personal experience.

Pre-operative fine-needle aspiration biopsy findings have been compared with those of post-operative histopathology in 146 patients with parotid masses. Post-operative histology showed 124 benign and 22 malignant lesions: pre-operative fine-needle aspiration biopsy correctly identified 118/124 (95.1%) benign masses with an accurate classification of the tumour in 111/118 cases (94%). Fine-needle aspiration biopsy identified malignancy in 12/22 cases (>50%). In the remaining 7 cases (six benign lesions and one malignant), cytology was not diagnostic. There were no false positive cases. In the present study, the accuracy, sensitivity and specificity of cytologic findings were, respectively, 94%, 57.2% and 100%. The accuracy of fine-needle aspiration biopsy was seen to be higher in benign than in malignant lesions. Fine-needle aspiration biopsy represents a first choice diagnostic tool for the study of palpable head and neck masses excluding abscesses and vascular neoplasms. However, for a correct diagnosis, great skill is required and cytology does not always reach the sensitivity and specificity of post-operative histology. Therefore, in the presence of a palpable head and neck mass, resistant to medical treatment, surgery is still strongly indicated and cytology is very useful in planning the surgical approach.

Adolescent↗
PubMed2002

[Surgical features on intraoral approach for the management of isolated zygomatic arch fractures].

The Authors report on their experience of 18 patients with isolated fractures of the zygomatic arch who were treated via intraoral approach. The procedures were performed between the 2nd and 8th post-trauma day and the results obtained were evaluated via post-operative CT scan and periodic follow-up visits for six months. In describing the surgical technique, the Authors recommend that the fracture be reduced with the patient's mouth open, in order to overcome the anatomical obstacle constituted by the coronoid process of the mandible and avoid, as far as possible, external approaches and osteosynthesis with screws or miniplates, which often give rise to unaesthetic results and localized pain. In conclusion, this approach is seen to be the method of choice in the treatment of isolated zygomatic arch fractures in that it is simple, effective and substantially free from complications.

Humans↗
PubMed2001

[Unusual case of pharyngeal-laryngeal Wegener's granulomatosis].

Wegener's granulomatosis is characterized by necrotizing granulomas with vasculitis in the upper and lower respiratory tracts, systemic vasculitis and focal necrotizing glomerulonephritis. Along with this so-called classic form, a new clinical entity has been added in recent years: granulomatosis located in a single site without any form of systemic manifestation. In otorhinolaryngology the disease is manifest at the outset in 72% of the cases while it appears later in an extremely high percentage of the cases (92-100%). The nasal sinus site is the region most often affected while the areas least affected are the larynx (16% with only 2% at onset) and oropharynx (10% with only 2.5% at onset). The authors present a clinical case of pharyngeal-laryngeal localization and list the most important otorhinolaryngological sites for onset of this disorder. They discuss the diagnostic aspects of this pathology: clinical history, histopathological findings, serological results and, in particular, the positive testing of anticytoplasmatic antibodies vs. neutrophil polymorphonucleate granules (c-ANCA). In this regard, emphasis is placed on the fact that c-ANCA are highly specific being positive in 97% of the cases. Sensitivity appears to depend on activity and extension of the disease with values fluctuating from 60% for locoregional forms to 93% for generalized forms. The authors indicate that the location found in the present case--at the laryngeal-pharyngeal region boundary--is important for the clinical history, histopathological data and response to specific therapy (cyclophosphamide and desamethasone) for a diagnosis of localized Wegener granulomatosis, even when c-ANCA do not test positive.

Adult↗
PubMed2000

Rhinoscintigraphy: a simple radioisotope technique to study the mucociliary system.

PURPOSE: This was a radioisotope study of nasal mucociliary clearance of total and subtotal nasal obstruction. METHODS: Rhinoscintigraphy was performed by insufflating 1.85 MBq (69 mCi) Tc-99m MAA in 20 patients. Six cases were regarded as the control group, because the presence of small spurs does not affect nasal patency. The remaining 14 patients had various rhinopathic conditions. Two regions of interest were selected, one in the nasal cavity and one in the pharynx. Mucociliary transport speed was calculated. RESULTS: This parameter appeared to be a sensitive index for the assessment of the degree of mucociliary alteration. It showed that polyposis impairs mucociliary transport most severely, thus confirming the results of other published studies. CONCLUSIONS: Rhinoscintigraphy proved to be a reliable, easily reproducible, and harmless method, so it may be used for follow-up examinations in patients who have had surgery of the nose and paranasal sinuses, and for drug therapy of rhinopathic conditions.

Adult↗
PubMed2000

[Use of SPECT with (99m)Tc-Sestamibi in a patient affected by laryngeal carcinoma and parathyroid adenoma].

We report the case of a patient with a laryngeal carcinoma in whom asymptomatic hyperparathyroidism was also detected during the preoperative work-up. A planar (201)Thallium/(99m)Tc-pertecnetate subtraction scintigraphy was performed in order to locate the suspected parathyroid adenoma. The study showed a single area of increased (201)Thallium uptake just above the thyroid isthmus, likely due to the laryngeal tumor. The scintigraphic study was repeated using (99m)Tc-Sestamibi and (99m)Tc-pertechnetate and employing the SPECT technique. Both SPECT studies made it possible to identify correctly the parathyroid adenoma, located inferiorly and in a posterior position to the lower third of the right thyroid lobe. The laryngeal tumor and parathyroid adenoma could be excised in a single surgery session. This case is of interest due to the rarity of the coexistence of two neck tumors and the clear advantage shown by the SPECT technique with (99m)Tc-Sestamibi over the planar technique with 201Thallium.

Adenoma↗
PubMed1999

[Tc99m-sestamibi SPECT and head and neck tumors: preliminary data].

After underlining recent progress in nuclear medicine diagnostics, even in oncology, the authors describe the most important methods used and oncotropic capacity of some radiodrugs currently used in clinical practice: i.e. perfusion tracers. Then they present the results of a personal experience using Tc99m-SestaMIBI SPET in detail. Fifteen patients suffering from various primary head and neck neoplasms underwent systematic clinical evaluation, endoscopy, CT and/or MRI and Tc99m-SestaMIBI SPET. The authors then briefly describe the method and underline the fact that the literature lacks any homogeneous data on the use of Tc99m-SestaMIBI SPET in the study of head and neck neoplasms. The results indicate that the method is reliable in identifying both primary tumors and laterocervical metastases. Then, taking indication from the only case currently available on post-radiotherapy recurrence, the authors suggest an interesting field of application for this technique: the study of post-radio-chemotherapy and/or surgery recurrences. In conclusion, the authors underline the valid contribution this method currently offers both in diagnosis and follow-up as well as its future of ever expanding clinical applications.

Adult↗
PubMed1992

Plexiform neurofibroma of the cervical portion of the vagus nerve.

The authors describe a rare case of plexiform neurofibroma of the cervical portion of the vagus nerve, and discuss its aetiopathogenesis, clinical, histological and therapeutic features, emphasizing the difference from other benign tumours of the vagus nerve. The clinical characteristics of the mass, ultrasound tomography, CT scanning and digital subtraction angiography were useful in defining its extension and relationships with the surrounding structures. Surgery is the treatment of choice. After mentioning the most commonly employed surgical approaches, they emphasize the advantages of the lateral-cervical approach which allows a wide exposure of the possible sites of origin of the tumour and its complete removal. Finally they stress the need of an accurate histological and immunohistochemical examination in order to differentiate neurofibromas from neurilemmomas.

Adult↗
PubMedDate not supplied

[Magnetic fields evoked by auditory stimuli: a normative study].

After outlining the fundamentals of biomagnetism and their possible clinical applications, the authors report the results of a normative study on auditory magnetic fields performed on 18 normally hearing subjects between the ages of 25 and 30. Having presented a thorough review of the literature, they then describe the recording technique employed, the dcSQUID biomagnetic system for signal detection, the shielded room, the characteristics of the stimulus. The auditory magnetic response is characterized by three main waves (P4Om, N100m, P200m) whose latency and amplitude values were calculated. Moreover, in order to localize dipolar activity, certain parameters, such as P and T, were taken into consideration. Localizations were made using a spherical volume conductor or with MRI, which was in any case employed in all the subjects. The waves, especially the N100m recorded contralaterally to the stimulus, showed a reduced latency and an increased amplitude when compared to those recorded ipsilaterally. Moreover, a systematic posterior shift of the N100m source into the left hemisphere with respect to the right one was detected. In conclusion, the authors emphasize the need to study electric as well as magnetic responses in order to better understand auditory cortical functions.

Acoustic Stimulation↗