Biomedical subjects
Publications and source records attributed to L D Evdokimov.
It was shown that rat blood plasma contains two enzymes that inactivate alkaloids by transforming them into N-oxides. Both enzymes are hemoproteins: one of them consists of three different polypeptides with Mr of 63, 35 and 12 kD, while the other one is a single polypeptide with Mr of 73 kD. Both enzymes exhibit cooperative properties.
A xenobiotics-inactivating hemoprotein related to the class of pharmacologically active compounds (cholinolytics) was detected in rat blood. Ammonium sulphate fractionation, DEAE cellulose chromatography and gel filtration on Sephadex G-75 resulted in 750-fold purification of the protein; its Mr = 73 000-80 000. Multiple injections of the protein to experimental animals led to a 2-3-fold increase of the protein content in the blood.
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