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Biomedical subjects

L D Robinson

Publications and source records attributed to L D Robinson.

At least 19 recordsLinked to original sources
PubMed1988

Skull metastases from follicular thyroid carcinoma.

Distant metastatic disease from thyroid carcinoma is becoming a rare problem. Physicians and the public are increasingly aware of minimally invasive methods of early diagnosis of thyroid malignancy, such as fine-needle aspiration with cytologic examination. Total thyroidectomy itself has become less associated with morbidity than it once was. We describe three patients with follicular thyroid carcinoma metastatic to the skull who were seen recently. Two of these patients had masses neglected for 20 and 50 years, respectively. The management of this disease entity is discussed.

Adenocarcinoma↗
PubMed1988

Head and neck malignancies in children: an age-incidence study.

One hundred forty-seven (147) children under 18 years have been treated for head and neck malignancies at Texas Children's Hospital from 1970 to 1985 and form the data base for this study. In order of frequency, the most common tumors were lymphoma, Langerhans' histiocytosis (LH), rhabdomyosarcoma, neuroblastoma, and other soft-tissue sarcoma. Children under 2 were most likely to have LH; those from 3 to 5, LH or lymphoma; and those over 5, lymphoma.

Age Factors↗
PubMed1979

Identification of a neutrophil chemotactic inhibitor in a patient with recurrent pyoderma.

Host defense mechanisms were studied in a patient with recurrent pyoderma of the scalp. Evaluation of the patient's inflammatory response demonstrated normal yeast phagocytosis, normal capillary tube migration, normal results from a nitroblue tetrazolium dye test, and significantly decreased neutrophil chemotactic response (NC). The impaired NC was associated with a heat labile plasma inhibitor. Chromatography of the patient's and of normal human plasma demonstrated three distinct protein peaks. Chemotactic inhibitory activity was found in the third peak of the patient's plasma but not in the control plasma. Normal in vitro NC was restored when greater than 40% normal human plasma was added to the column fractions that contained the inhibitor. Based on these findings, a subsequent exacerbation of the patient's pyoderma was treated with fresh frozen plasma, and dramatic clinical improvement occurred within 72 hours.

Adult↗
PubMed1977

Partial characterization of in vivo chemotactic activity: comparison to human C5a.

Spontaneous eosinophil chemotactic activity (SECA) can mediate the directed movement of human eosinophils and neutrophils. Preliminary characterization of SECA has been carried out. SECA is nondialyzable and heat-stable (56 degrees C, 30 min). Chromatography on Sephadex G-75 demonstrated that SECA had elutional and functional properties similar to C5a (prepared from endotoxin-activated normal sera). Polyacrylamide gel electrophoresis (PAGE) with the use of 15% bisacrylamide gels of lyophilized, chemotactically active column fractions demonstrated a single protein band of identical electrophoretic mobility from either SECA or C5a preparations. Enzymatic hydrolysis with carboxypeptidase B, a known inhibitor of C5a activity, significantly decreased chemotactic activities of C5a and SECA. The addition of purified anti-C5 to either SECA or C5a significantly inhibited chemotactic activity. SECA is naturally occurring chemotactic activity identical to human C5a. Thus C5a may be an important source of in vivo chemotactic activity in various inflammatory disorders.

Antibodies↗
PubMed1977

Allergy and infection.

The majority of infectious asthma in children is of viral etiology. The respiratory syncytial and parainfluenza viruses are the etiologic agents in most young children, whereas rhinovirus primarily initiates asthmatic episodes in older children. Short-term or alternate day maintenance corticosteroid therapy probably does not significantly increase the asthmatic child's susceptibility to infection.

Adrenal Cortex Hormones↗
PubMed1977

Dyssegmental dwarfism: a new syndrome of lethal dwarfism.

Dyssegmental dwarfism is an autosomal, recessively inherited, lethal, generalized chondrodysplasia characterized by micromelia, cleft palate, and variable limited mobility at the elbow, wrist, hip, knee, and ankle joints and, in some cases, by occipital encephalocele, inguinal hernia, hydronephrosis, hydrocephalus, and patent ductus arteriosus. Roentgenographically, there is a marked variation in the size of all vertebrae with some anterior wedging, coronal clefts, and lack of caudal interpediculate widening. In addition, there are short, broad tubular bones with metaphyseal widening, variable bowing of the tibia, fistula, femur, radius, and minimally the ulna. In the feet, the talus and calcaneus are poorly modeled, and the 1st metatarsal and 1st proximal phalanx are enlarged. The striking similarities among these cases, as well as the others in the literature, argue strongly for their being a common defect in embryogenesis. However, there is also evidence of heterogeneity. Our case reported here has distinct hypoplasia of the scapulae, absence of carpal ossification centers, and lack of flaring of the ilia, whereas the other cases show well-developed scapulas, accelerated carpal bone maturation, and a wide-flared ilia.

Diagnosis, Differential↗
PubMed1975

SECA, a new mediator of the human eosinophil response.

Spontaneous eosinophilic chemotactic activity (SECA) present in human sera can mediate the directed movement of normal human eosinophils. Our data utilize normal peripheral blood eosinophils obtained from subjects with 500 eosinophils/m3 or less. SECA is defined as that chemotactic activity for eosinophils present in serum that has been heat-inactivated immediately after collection. It was demonstrated in patients with severe chronic eczema with eosinophilia (20 to 30%); mixed collagen vascular disease with vasculitis; clinical serum sickness; acute glomerulonephritis, and chronic membranoproliferative glomerulonephritis. Control sera were obtained from normal, healthy individuals. The data indicated: (1) that SECA in patient sera was significantly higher than in control sera; (2) when activated by endotoxin, no additional chemotactic activity was generated from patient sera over that spontaneously present--by contrast, addition of endotoxin to control sera did result in increased chemotactic activity; (3) sera from patients with extrinsic bronchial asthma had no SECA.

Acute Disease↗