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Biomedical subjects

L D Serova

Publications and source records attributed to L D Serova.

At least 19 recordsLinked to original sources
PubMed2003

[Treatment of purulent-inflammatory complications of polytrauma, diabetes, infected pancreonecrosis].

Results of Antilympholin-K3 use in combined treatment of purulent-inflammatory complications in polytrauma, diabetes, infected pancreonecrosis are analysed. Thirty-nine patients aged from 19 to 74 years were treated. Double injection of Antilympholin-K3 enhanced phagocytic activity of neutrophils, phagocytic index, chemiluminescence of mononuclears and neutrophils, immunoglobulins concentration. Positive dynamics in immunological indices is accompanied by improving clinical status, cleaning of postoperative wounds from pus, improving of epithelisation.

Adult↗
PubMed2002

[HindIII DNA-polymorphism of lipoprotein lipase gene in elderly patients with ischemic heart disease].

AIM: To determine incidence of HindIII alleles of lipoprotein lipase (LPL) in Russian elderly patients with stable effort angina (SEA) functional class II-III regarding lipid metabolism. MATERIAL AND METHODS: Genotyping by LPL gene was performed in 103 patients with SEA. Of them 13 patients survived myocardial infarction (MI), 29 patients had diabetes mellitus. RESULTS: Incidence of alleles of HindIII DNA-polymorphism of LPL gene both in healthy and IHD patients is comparable with that in the West European populations. CONCLUSION: Genotype H+H+ of LPL gene is one of the markers of predisposition to MI, while allele H- is one of the resistance marks.

Adult↗
PubMed2002

[ACE gene I/D-polymorphism and hereditary predisposition to myocardial infarction].

The authors compare distribution of genotype frequencies and alleles of I/D of ACE gene polymorphism in patients with various forms of ischemic heart disease (IHD): with acute myocardial infarction (MI), stable effort angina (functional class II-III); in patients with postinfarction cardiosclerosis (PICS). A relationship was found between I/D polymorphism and acute MI. Frequency of DD genotype in MI patients was 0.57, in controls--0.21, p < 0.0001, RR = 4.9. The DD genotype may serve a marker of hereditary predisposition to MI. Genotype DD frequency in the group with acute MI was higher than that with PICS. In acute MI frequency of allele D was 0.76, in PICS--0.51, p < 0.0005. It is suggested that low frequency of genotype DD in the PICS group results from higher lethality of patients with DD genotype in the nearest rehabilitation period. Patients with repeated MI have a significantly higher frequency of genotype DD and complications after MI. Thus, there is a relationship between insertion-deletion polymorphism of ACE gene and myocardial infarction. Deletion DD genotype raises the risk to develop MI and probability of life-threatening complications and repeated MI.

Bacterial Outer Membrane Proteins↗
PubMed2001

[Antigens of histocompatibility in children with myasthenia gravis].

HLA-phenotype was determined in 59 juvenile patients of Russian nationality and in their 50 relatives by means of lymphocytotoxic test. There was a positive association with HLA-A1, B8 and DR3 and the negative one--with HLA-A2, A9, B5, B7, and DR7. The frequencies of HLA-A1, B8, DR3 were higher in boys than in girls with myasthenia. There were no significant changes of HLA frequencies in ocular form of the disease in comparison with the healthy group. The frequencies of HLA-B8 and DR3 were significantly higher in relatives of the patients with juvenile myasthenia than in control population.

Child↗
PubMed2001

[Immune and interferon system in patients with bronchial asthma].

We studied the levels of acute inflammation phase proteins (AIPP), production of alpha, gamma and serum interferons, the activity of epsilon-receptors of T-lymphocytes in 39 patients with bronchial asthma (BA). Correlations were made with the process severity and basic therapy. We discovered imbalance of immunoregulatory mechanisms: enhanced AIPP synthesis, low production of induced alpha and gamma interferons, elevated concentrations of poor-differentiated T-lymphocytes. This confirms persisting inflammation in BA.

Asthma↗
PubMed1999

[Results of cytological studies of smears of the buccal mucosa in elderly subjects].

Cytological studies of smear impressions from different sites of the buccal mucosa were carried out in 25 subjects (22 women and 3 men) aged 61-85 years. A group of healthy subjects aged 16-33 years were controls. Cells of different degree of differentiation are present in normal mucosa with different epithelial status: intermediate cells, mature cells with pyknotic nuclei, or surface cells without nuclei. In elderly subjects, the percentage of anuclear cells in the last stage of differentiation is increased in almost all sites of the mucosa, with the main characteristics of cytograms of young subjects retained.

Aged↗
PubMed1998

[Dental care for patients with hematological diseases].

Clinical and cytological studies in 41 hematological patients aged 19-70 years showed appreciable shifts in the immune status and nonspecific reactivity virtually in all examinees. Layers of cellular epithelium of late (V-VI) and early (III-IV) stages were more often detected in smears impressions than individual cells. Cells of stages I-II were scarce and never formed layers. In patients with leukemia, signs of dissociation of epitheliocyte nucleus and cytoplasm maturation were observed ("mature" cytoplasm and "young" nuclei). These specific shifts should be borne in mind when rendering dental care to hematological patients.

Acute Disease↗
PubMed1993

[The distribution of class-I HLA antigens in patients with multiple myeloma].

HLA antigens class 1 have been investigated in Russian patients with multiple myeloma. Compared to controls, myeloma patients demonstrated more frequent occurrence of antigens A11 and B7. Antigen A11 was more common for males and subjects with early response to treatment. Antigen B7 was more frequent in females with the slow response. These correlations are significant without correction on the number of the antigens studied. Association heterogeneity in males and females, in different therapy responders gives grounds for a differential approach to myeloma pathogenesis, choice of drugs, prognosis of survival.

Adult↗
PubMed1991

[Tissue typing using a Soviet automated luminescent microscope-photometer].

Automated fluorescent microscope developed by the authors permits photometry of microquantities of cellular suspensions in scanning standard 60-well plates with a flat bottom. Automated and semiautomated modes of operation are possible. Fluorescent stains and schemes of staining the examined cells that yield stable results in the lymphocytotoxic test have been selected. Comparative analysis of the efficacies of histocompatibility antigens detection by the routine and the fluorescent technique has shown a number of advantages of the fluorescent method. Specific features of fluorescent stains used for staining live cells are described.

Histocompatibility Testing↗
PubMed1991

[The role of the major histocompatibility complex antigens in the development of allergic diseases in the Korean population].

Association has been detected between incidence of HLA-antigens and allergy prevalence in Koreans. Antigen B8 occurs significantly more frequently whereas A3 more rarely in Koreans with allergy. Determination of HLA-antigens distribution may be helpful in prognosis of allergic diseases possibility. Allergies are a rare finding in Koreans due to less common occurrence of antigens AI and B8 in them against Europeans.

Adolescent↗
PubMed1990

[Immunocorrective therapy of hematologic diseases].

Changes in the immunological parameters have been studied in the course of treatment with antithymocytic globulin and chemotherapeutic preparations included in the treatment protocols for aplastic anemia and acute leukemia. A possibility of determining the optimal immunocorrective agent dosage is demonstrated as related to its effect on the functioning of the immunocompetent cells in vitro.

Acute Disease↗
PubMed1990

Comparison of HLA antigen spectrum in atherosclerosis of various localization.

The spectrum of HLA antigens was studied in 619 control subjects and 357 patients with atherosclerosis of various localization (coronary, cerebral, and lower limbs arteries). Comparative analysis has shown both agreement and differences to exist between patient groups depending on atherosclerosis localization. Significant differences were also found in the level of various lipid components. A relationship between HLA antigens and lipid markers was demonstrated, especially between locus B and C antigens and HDL cholesterol level. The authors believe the findings can be utilized to determine predisposition to atherosclerosis of various localization.

Adult↗
PubMed1989

[Bone marrow transplantation (immunology, immunosuppression)].

Clinical effectiveness of bone marrow transplantation has been analyzed in 83 patients with aplastic anemia. Bone marrow of non-related donors with high degree of histocompatibility, according to the antigen system HLA of loci A, B, C and DR, was used. Freshly prepared bone marrow was transplanted in doses from 3.4 x 10(9) to 15 x 10(9) myelokaryocytes. Immunosuppression was provided by corticosteroid hormones and antithymocytic globulin. Complete or partial remission lasting for more than a year was recorded in 56 patients. Formed elements of the donor's blood were detected in the blood of 39% of the patients (the observation period lasted from 1 to 8 months). Symptoms of a secondary disease were observed in 29% of the patients. Significant changes in the cellular immunity parameters were recorded in all the patients investigated. The character of the time course of these changes may serve as a prognostic factor of myelotherapy effectiveness.

Anemia, Aplastic↗
PubMed1989

[Effect of cytostatic and hormonal drugs on the phagocytic activity of neutrophils of leukemia patients].

Based on the data concerned with blood cells from 12 normal persons and 18 patients with acute leukemia, the action of the clinically applied cytostatics and hormonal drugs (6-mercaptopurine, cytarabine, vincristine, rubomycin) on granulocyte functions was investigated in vitro and in vivo (in patients). The respective characteristics were found to be in a good enough agreement, enabling the prediction of the effect of polychemotherapy on granulocyte functions (the digestion capacity). It has been established that each of the drugs under study changes the characteristics of granulocytes to a different degree. The individual sensitivity of the digestion capacity of phagocytes to the drugs under study does not depend on the disease pattern or initial characteristics of the phagocytic activity of the cells.

Antineoplastic Agents↗