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L D Sullivan

Publications and source records attributed to L D Sullivan.

48 records · Page 3Linked to original sources
PubMed1982

A critical evaluation of a specific radioimmunoassay for prostatic acid phosphatase.

A radioimmunoassay (RIA) method for acid phosphatase detection was compared to a standard enzyme assay using sera from 210 normal volunteers and 285 patients with prostatic disease. Statistical and clinical comparisons were made between defined subgroups. All 55 normal females had RIA detectable serum acid phosphatase, implying that this assay cannot be entirely specific for enzyme of prostatic origin. Urinary catheterization did not affect acid phosphatase levels. In all stages of carcinoma there were more acid phosphatase elevations by the RIA method than enzyme method, but neither assay could differentiate intracapsular cancer from benign prostatic hyperplasia. A small number of patients with biopsy proven negative nodules had marginally elevated values, suggesting as obligation for closer follow-up. The RIA method may be superior for monitoring patients with more advanced malignancy. Additional practical advantages of the RIA include relative simplicity and elimination of the special serum handling required for the enzyme assay.

Acid Phosphatase↗
PubMed1982

Vesicopsoas hitch: a versatile procedure.

The vesicoposoas hitch is an ideal operation for the management of lower ureteral injury and disease requiring replacement of varying lengths of ureter. It is safe and easy to perform, complications are minimal and the success rate is high. In combination with the Boari flap and downward mobilization of the kidney, up to 70% of the ureter may be replaced by this technique. The authors describe their experience between 1970 and 1980 with 52 patients treated by the vesicopsoas hitch, with and without the Boari flap.

Adult↗
PubMed1981

The significance of prostatic acid phosphatase in adenocarcinoma of the prostate.

Our radioimmunoassay for prostatic acid phosphatase was compared to commercial radioimmunoassay kits. A close correlation among all 3 assays was found in control groups, and in patients with benign prostatic hyperplasia and adenocarcinoma of the prostate. These results also were compared to recent reports from other centers using similar methodologies. In 7 to 15 per cent of the patients with bone metastasis normal levels of serum prostatic acid phosphatase were found. Variability in prostatic acid phosphatase production by the tumor may account for this finding. Elevated levels of prostatic acid phosphatase were associated more commonly with less differentiated primary tumors. A low percentage of prostatic acid phosphatase elevations in patients with early localized and incidental adenocarcinoma was found for the 3 assays evaluated. These factors, along with the falsely positive rates in patients with benign disease, limit severely the application of these assays to the screening of male patients at risk for adenocarcinoma of the prostate.

Acid Phosphatase↗
PubMed1981

Penile prosthesis for organic impotence.

Only in the past decade have surgeons been able to offer men with impotence due to organic disease procedures that have good success rates. Between 1976 and 1979 the authors implanted paired silicone penile prosthesis in 35 such men, in most cases following cancer surgery. The procedure described is technically not difficult. Thirty-three of 35 patients have a functioning prosthesis. There were four complications but these should be rare if patients are properly selected. Patient satisfaction is high. No patient requested removal of the prosthesis.

Adult↗
PubMed1979

Severe prostatic calcification after radiation therapy for cancer.

Severe symptomatic prostatic calcification was seen in 3 patients who had carcinoma of the prostate treated initially with transurethral resection, followed in 2 to 4 weeks by definitive radiation therapy. This complication is probably preventable if an interval of 6 weeks is allowed between transurethral resection of the prostate and radiation therapy.

Aged↗
PubMed1979

Surgical management of renal cell carcinoma at the Vancouver General Hospital: 20-year review.

Over a 20-year period 143 patients with renal cell carcinoma were treated surgically at the Vancouver General Hospital. The results of simple nephrectomy are compared to those of radical nephrectomy. The authors conclude that radical nephrectomy (including node dissection) is a useful staging procedure but provides little or no long-term therapeutic benefit over simple nephrectomy. They stress the need for new adjunctive therapy.

Adenocarcinoma↗
PubMed1979

Primary malignant tumours associated with renal cell carcinoma.

Of 360 patients with primary renal cell carcinoma seen at the Vancouver General Hospital between 1957 and 1976, 33 had associated primary malignant lesions. A review of the 166 patients who had ablative surgery revealed that they were four times more likely to have a synchronous primary malignant tumour than the other patients. The incidence of asynchronous primary malignant tumours was not increased. This may be related to the fact that the patients' full life charts were not available. In 18 patients dying of other causes in whom an incidental renal cell carcinoma was found, 5 (28%) died of other malignant tumours. In a comparable age group from the general population, 19% are at risk of death from malignant disease. The frequency of synchronous contralateral renal cell carcinoma in our series was 50 times greater than the frequency of primary renal cell carcinoma in a corresponding sector of the general population.

Adenocarcinoma↗