Biomedical subjects

L Dănăilă

Publications and source records attributed to L Dănăilă.

At least 19 recordsLinked to original sources

PubMed2005

Paraganglioma of the cerebellopontine angle. Case presentation and pathological considerations.

Paragangliomas (glomus tumors) arise from the extra-adrenal neuroendocrine system. They are benign but locally aggressive tumors, causing bone destruction and compression related symptoms. We present a case of paraganglioma of the cerebellopontine angle. Emphasis on possible difficulties in clinical, imaging or pathological identification, and surgical removal is done. To the best of our knowledge, only one more case was reported arising in the cerebellopontine angle.

Cerebellar Neoplasms↗

PubMed2005

p53 protein and bcl-2 expression in glioblastomas. Pathological correlations in a comprehensive series.

p53 and bcl-2 are two well-known antiapoptotic factors associated with gliomas, and mostly astrocytic tumors. In the present study we assessed, by immunohistochemistry, the expression of these two factors in a series of 50 glioblastomas. The correlations between their expression and several tumor-related factors (age, location, recurrence, proliferating potential) were investigated. Our results suggest that a valuable correlation between these factors cannot be found. This is in discrepancy with some literature data, which emphasize strong relations of p53 and bcl-2 in oncogenesis spreading or final prognosis. Further studies are needed, with unique, standard procedures for these evaluations.

Adult↗

PubMed2004

Clinical aspects of photodynamic therapy--Romanian experience.

Photodynamic therapy is an emerging method for local destruction of tissue by generating toxic oxygen species using light absorbed by an administered or an endogenously generated photosensitiser. It is a promising treatment for patients with cancer. More recently it has found increasing use as a method of therapy for non-cancerous illnesses. Following administration of a photosensitiser occurs an accumulation or retention in areas of cancer and disease relative to adjacent normal tissue. The photosensitiser is inactive until irradiated by light, following which cellular destruction occurs. This explanation is a good reason for the scientific and clinical interest in photodynamic therapy.

Aged↗

PubMed1977

Haematological aspects of hypophyseal tumours.

This paper is devoted to the study of anaemia in patients with hypophyseal tumours. Anaemia with a red blood cell count of 2.4 million/mm3 to 3.9 million/mm3 was found in 60 of 280 patients (21.7%) with hypophyseal tumours; 52 of the 60 patients were operated on. Similar changes were observed in 25 of 60 cases (41.7%) of craniopharyngioma. Apart from anaemia and a low haemoglobin some of the patients also had anisocytosis, anisochromia, leucocytosis, and haemolytic shock.

Adolescent↗

PubMed1977

Spinal dermoid tumours.

The present work is a detailed analysis of 12 cases of spinal dermoid tumours operated on between 1935 and 1976. Of these 11 were medullary (3 intramedullary and 8 subdural extramedullary), representing an incidence of 0-80% of medullary tumours, and 1 was an extraspinal coccygeal tumour. Most of the tumours were located in the spinal canal and conus. Good results were obtained following total ablation in 7 cases and partial removal of the tumour in 5 cases.

Adolescent↗

PubMed1977

Cranial eosinophilic granuloma.

Investigations were carried out on 27 cases of cranial eosinophilic granuloma: 16 males (59%) and 11 females (41%). The mean age was 25 years, the extremes being 2 years and 65 years. The location in 21 cases (80%) was exclusively in the calvarium (9 frontal, 8 parietal, three occipital and 1 temporal), orbital in two cases, fronto-orbital one case, base of the skull in the left parasellar region one case, left frontal subdural with chronic subdural haematoma one case and one case left occipital and petrosal bone. All the cases were diagnosed histologically. In 18 cases the tumour was removed at operation. Recurrences occurred in four of these cases (15%), three of whom died (11-5%). Four of the patients received steroid therapy and four steroid therapy combined with X-ray therapy. The evolution was favourable in all these cases.

Adolescent↗

PubMed1977

Logorrhea syndrome with hyperkinesia.

The present paper reports on 13 cases of logorrhea syndrome with or without hyperkinesia, or hyperkinesia without logorrhea, with lesions at various levels of the nervous system. Lesions of the ascending reticular inhibitory system are incriminated. The mechanism producing this syndrome is discussed.

Brain Diseases↗

PubMed1976

Cerebral dermoid tumours.

Four cases of cerebral dermoid tumour with an intraventricular, occipital and sellar location are reported, representing 0.04% of the verified cerebral tumours in the authors' statistics. A recurrence occurred after one year in the first case of intraventricular dermoid tumour; after the second operation aseptic meningitis developed and the patient died. In the second case microscopic examination revealed aspects of malignant transformation of the tumour. The symptoms did not differ from those of other cerebral tumours. Operations should be radical whenever possible, avoiding dispersion of the tumour contents in order to prevent a recurrence or aseptic meningitis.

Adult↗

PubMed1976

Supratentorial dissemination of medulloblastomas.

The present paper reports on 13 cases of medulloblastoma with supratentorial dissemination. With reference of these cases the authors discuss the pathogenetic probabilities of the dissemination of brain tumors, their evidence and treatment, emphasizing the importance of cerebral scintigraphy formed periodically in all patients previously operated of medulloblastoma. When dissemination is detected radiotherapy may give good results. If the symptomatology is very accentuated the secondary supratentorial tumour has to be removed.

Adolescent↗

PubMed1975

Intrasellar abscess.

A case of intrasellar abscess in a 31-year-old male, with pituitary insufficiency, visual field and acuity disturbances, is reported. In the pus extracted at surgery E. coli and Staphylococcus haemolyticus were identified. The patient died 20 days after the operation. Necropsy revealed the fibrous capsule of an abscess in the hypophyseal region and putriform tissue at the level of the hypothalamus, with three small tumours one of which proved to be a craniopharyngioma.

Adult↗

PubMed1975