[Human papilloma virus infections in gynecology].
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Biomedical subjects
Publications and source records attributed to L Damianov.
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The authors discuss one of the most frequently founded cause of spontaneous abortions and prematurity birth--the bacterial vaginosis. The diagnostics is easy and not expensive. In the complex of health's caries it is necessary to include and the prophylaxis of diagnostics and harmless and efficient treatment with local drug as example "Dalacin V".
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The authors review the effect of the oral contraceptive Mercilon on menstrual cycle, contraceptive efficacy, lipid profile, safety profile and adverse effects in a group of 32 women, included in the survey. The results of the trial show excellent contraceptive effect with Pearl Index of 0.00 and good control over the menstrual cycle. No negative or unfavorable effects were seen on the lipid profile as well as on the liver kidney and coangulant system function. Minor side effects were seen in only 5% of the patients.
Thirty-four patients at the end of pregnancy were treated with ciclopiroxolamine (Dafnegin) vaginally for the period from January to October 1998. The effect of therapy was evaluated. One hundred women were examined and 34 (34%) of them had vaginal candidiasis. All patients were treated with ciclopiroxolamine (Dafnegin) vaginal creme once time daily for 14 days. Thirty-two patients (94.11%) were healthy, in two patients (5.88) candidiasis was reduced to minimal colonies.
The effect and side reactions of bromocriptin of the firm "Richter" were evaluated in this study. Fifteen women with interrupted pregnancy between 14 and 28 gestational week were explored. To prevent the onset of lactation treatment was started within a few hours after abortion in dosage 2.5 mg (one tablet) twice daily, for 14 days. The prolactin-lowering action began to take effect 2 hours after ingestion of the first tablet, peak after 5 hours, and maintained for 8-12 hours. In course of treatment 14 days in dosage two times daily, the lactation was inhibited in 100% of the cases, in 65% of them she was stopped at the first three days of therapy, in 15% of the cases she was stopped between 3rd and 7th day, and in 20%--after the 7th day of the treatment. The adverse reactions nausea, dizziness, vomiting, diarrhoea, constipation, headache and orthostatic hypotension were transitory. They were observed rarely, and during the first 3-5 days of treatment disappeared.
The authors check the effect of the substitutional treatment of the pregnant patients with the uterine paints and contractions in the second and third months periods of the pregnancy with "Magne B6"--Sanofi. In the group of the examined patients the Mg deficiency that is the cause for these suffering has been established. After the substitutional treatment with "Magne B6" the described suffering disappeared and clinical-lab values of Mg in the serum and urine normalized.
The author reveal the results of treatment with ciclopiroxolamine of women suffering from mycotic colpitis and using OC's. The research covers 26 women users of monophasic OC's with mycotic colpitis during the last 2-3 weeks before the research. The cause for the colpitis in 92% of cases is Candida albicans. The treatment was successful in 84.6% of the cases after the first 6-day-course with Batrafen creme. With 7.7% the treatment course with Batrafen creme was repeated, and with another 7.7% was included oral antimycotic (itraconazol). After treatment was performed microbiological check-up that confirmed the positive result of treatment. The authors' conclusion is that Batrafen creme is an effective device suitable for application on patients, CO's users.
The authors are analyzing their results of the treatment with roxithromycin 150 mg of the pelvic inflammatory disease, caused by chlamydia trachomatis. 29 patients with proved chlamydial infection were treated. The most popular diagnosis was cervicitis. 23 patients were totally cured, 4 patients were with considerable better status after the treatment, and 2 of the patients were with insignificant amelioration of the status. A conclusion can be made, that the roxithromycin is a very good alternative of the existing treatment with doxycicline.
Endometriosis is one of the main causes of female sterility, leading not only to subjective complaints, such as anovulatory menstrual cycles and LUF syndrome, but also to appearance of antisperm antibodies due to the increased number of macrophages, We present our experience in the treatment of endometriosis with the GnRH analogue Zoladex, product of Zeneca, as well as in the treatment of antisperm antibodies with methyiprednizolon acetate, Depomedrol of Upjohn.
The authors compare the reliability of an enzyme method for diagnostics of chlamydial endocervicitis versus Clearview chlamydia test. The results suggest that the enzyme test may be applied with sufficient diagnostic reliability.
The conservative treatment of the condylomata acuminata by Solcoderm is local, painless and ambulatory. One application of Solcoderm by a capillary pipette covering the pathologic formations is enough--they become rapidly devitalized and disappear within 4 weeks. Secondary infections on the treated area are extremely rare.