Biomedical subjects
Publications and source records attributed to L Dann.
Pneumothorax may be spontaneous or can occur as a complication of chest trauma. Patients present with a wide range of symptoms, the severity of which may not correlate well with the degree of pneumothorax. Classification and current therapies are presented here.
Epistaxis is a common condition usually requiring only simple treatment. Occasionally, severe epistaxis may present as a medical emergency. The classification and management of this condition are presented here.
Acute anaphylaxis is a potentially life-threatening condition. It must be recognised early and treatment instituted promptly. Localised, severe allergic reactions and generalised anaphylactoid reactions should be treated in the same way as acute anaphylaxis.
Airway maintenance is a vital skill that is often poorly managed due to the failure to observe simple principles. Clearing the airway is essential before the use of airway adjuncts. This always must be in addition to adequate ventilation.
Mice selected by McClearn and Kakihana for differences in ethanol-induced sleep time were used as subjects. In Experiment 1, mice from the long-sleep (LS) and short-sleep (SS) lines were offered a choice of water or solution GS consisting of 3% glucose and .16% sodium saccharin (w/v); or a choice of water or solution GS + E that contained GS solution plus 4% ethanol (w/v). In Experiment 2, mice from the first experiment were provided with a three-way choice among water, solution GS, and solution GS + E. In both experiments, SS mice (alcohol-insensitive) consumed more GS + E than LS mice (alcohol-sensitive). In addition, female mice drank considerably more GS + E solution than male mice. Thus, consumption of sweetened ethanol in both a two-way choice (water and GS + E) and a three-way choice (water, GS, and GS + E) is dependent on both genotype and sex. High genetic sensitivity to ethanol was associated with low consumption, and vice versa. Although females consumed more alcohol than males, famales of these lines have not been previously found to show lower sensitivity to acute alcohol administration.
Escherichia coli mutants that are insensitive to colicins B and I hyperproduce and excrete the iron chelator enterochelin, which is an inhibitor of these colicins. These mutants are classified as exbA and exbB. The exbA mutants are chromium sensitive and require iron for growth, and the mutations are located in the tonB region at min 25 of the E. coli chromosome. tonB mutants in which the genome of phage lambda is inserted into the bacterial chromosome within the tonB gene also exhibit enterochelin excretion. The exbB mutants require methionine and probably result from deletions which are located between min 56 and 58. Colicin insensitivity, enterochelin excretion and methionine auxotrophy are recessive in exbB merodiploids. The methionine requirement of exbB strains is satisfied by cystathionine or homocysteine, and exbB mutants are sensitive to ethionine.
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