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Biomedical subjects

L De Santis

Publications and source records attributed to L De Santis.

85 records · Page 5Linked to original sources
PubMedDate not supplied

[Treatment of the early form of rectal carcinoma in the elderly].

The early rectal cancer which needs conservative surgical treatment should present some pathological characters: intramucosal site without muscularis invasion (pT1), high or moderate differentiated grading (GI-G2), no lymph node metastasis or vascular invasion. Total mesorectal excision is the gold standard for these neoplasms and permits very low resection or colo-anal anastomosis with sphincter function preserving. However, this type of surgery has still a high percentage of postoperative morbidity and mortality (some authors report respectively 40% and 5%). Therefore the local excision in selected cases is able to preserve the sphincter function and to reduce the postoperative complications with high probability of recovery.

Aged↗
PubMedDate not supplied

[Therapeutic strategy in neoplasia of the pancreas and ampulla].

The major symptoms of periampullary neoplasia are jaundice, lowering of weight, abdominal pain extending behind; diabetes, pancreatitis or exocrine pancreatic failure are uncommon. In the last years, surgery has been considered as the gold standard of the therapy because new technologies are able to reduce morbility and mortality. In the too advanced neoplasia, palliative surgical care permits better survival and quality of life. The duodenopancreatectomy today has a low perioperative mortality (0-3%) and an acceptable survival (15.25%). Good results were found for palliative surgery in unresectable neoplasms while in the inoperable patients we consider endoscopic and radiological treatments better than chemotherapy because they are able to correct the jaundice, improving quality of life (but not survival).

Aged↗
PubMedDate not supplied

[A multicenter study of child poisonings. Preliminary epidemiological results].

The project of a multicentre study of poisoning in children planned by 4 Italian pediatric departments to get epidemiologic and clinic information is presented. The study is carried out retrospectively on admissions during 1975-90 and prospectively during 1991-92. Poisonings are classified as not-confirmed, asymptomatic because of early treatment or symptomatic. In the latter group three degrees of severity are assessed. Diagnostic-therapeutic protocols will be elaborated and quality of the hospital care evaluated according to peer review methodology. Preliminary data on changing pattern of poisoning over the time and on main toxic agents involved in younger children are also reported. The first topic has been studied taking into account 1831 patients aged 0-13 years, admitted during 1977-79 and 1987-89. A decrease of exposures to drugs and an increase of poisonings under the age of 3 years have been observed in more recent period. On the other hand household products resulted to be the main poisoning agents in 1044 children under the age of 5 years during 1984-86. Lack of infant supervision by parents and possible influence of compulsory child resistant containers only for drugs are stressed. The findings suggest the need of health education campaigns in general population as well of safety devices for some domestic harmful products.

Age Factors↗
PubMedDate not supplied

[Chemotherapy of carcinoma of the cervix uteri. Current approaches].

In the present work, on the basis of the most current knowledges, the Authors analyse and discuss the pharmacological and clinical aspects of the chemotherapy of salvage for the advanced or recurrent tumoral forms, and of the "neoadjuvant" chemotherapy, employed before of surgery or radiotherapy during the primary treatment of cervical cancer.

Antineoplastic Agents↗
PubMedDate not supplied

Gabexate mesilate in the treatment of acute pancreatitis.

Despite controversial experimental and clinical findings, the use of Aprotinin (A) in the treatment of acute pancreatitis (AP) is still widespread in our country. Compared to A, Gabexate Mesilate (FOY) should have the following advantages: lack of antigenicity, low molecular weight with better cellular penetrance, wide inhibitory spectrum (against phospholipase A2 too) and good tolerability. In order to verify the efficacy of FOY versus, we decided to carry out a prospective multicenter (34 centers) randomized double blind trial in moderate-severe AP with FOY 3g/day versus A 1,500,000 U.I.K./day infused for 7 days with central venous line. Based on standard clinical, biochemical and radiological data, 199 patients suffering from AP were enrolled to the study from January 1989 to December 1990. The main admission criteria were: onset of the disease from no more than 72 hours, at least 2 Ranson positive criteria and C.T. evidence of acute pancreatic damage. Seventeen no protocol patients were excluded. The Etiology in the 182 analyzed patients (106 male, 76 female; mean age 57.6 years, range 21-91) were: biliary 102 (56%), alcohol 47 (25.8%), post-operative 13 (7.1%), unknown causes 13 (7.1%) and others 7 (3.8%). Median Ranson's Score was 3. CT examination showed 66 AP with edema, while 116 cases (63.7%) were recognized as severe forms with pancreatic necrotic involvement of 30% of the gland in 71 (61.2%), 50% in 31 (26.7%), and more than 50% in 14 (12.1%). Out of 182 patients, 91 were treated with A and 91 with FOY. The two groups were comparable regarding the main prognostic factors.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
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[Continuous subcutaneous administration of terbutaline in the therapy of threatening premature labour].

The purpose of this study was to evaluate the tocolytic efficacy of terbutaline, administered subcutaneously in a low-dose continuous infusion, and intermittent high-dose boluses. The population study consisted of 13 women admitted with the diagnosis of Threatened Preterm Labour. Before starting chronic infusion by terbutaline, patients received 48 hour of therapy with intravenous MgSO4 for acute tocolysis. Therapy with microinfusor was continued until the 37th week of gestation or until labor. The mean gestational age at the beginning of therapy was 25.6 +/- 3.5 and pregnancies were prolonged an average of 65.5 +/- 29 days. In any case uterine activity was diminished by terbutaline therapy in all patients. Patient tolerance was excellent and there were no significant complications due to the therapy.

Adult↗
PubMedDate not supplied

[A proposed classification of inguinocrural hernias. The classification of hernias in the inguinal and crural regions in the adult as a function of their surgical therapy].

Surgery for the treatment of inguinal and femoral hernias has recent years acquired numerous increasingly modern, innovative techniques. This has been possible thanks modern, innovative techniques. This has been possible thanks to the introduction of prosthetic material which is better tolerated by the tissues and to the utilization of new ways of approach. A new method of hernia classification, no longer based on anatomical criteria but on a broader evaluation which takes multiple aspects into account, is now needed to decide on valid criteria for choice of operation, at the same time expressing themselves in a common language which will allow the results to the verified.

Adult↗
PubMedDate not supplied

[Conservative therapy of hemorrhoids].

Conservative therapy of hemorrhoids can be curative at stage I and II of disease; further it rappresent a valid preliminary management for a better result of more aggressive treatments, be they surgical or not. Beside local and general drugs other aspects play an important role in conservative therapy of hemorrhoids: adequate local hygiene, correct diet, education to a physiological evacuation and last but not least stool frequency regulation.

Constipation↗