PubMed Health⌕ Search

Biomedical subjects

L De Zanche

Publications and source records attributed to L De Zanche.

32 records · Page 2Linked to original sources
PubMedDate not supplied

Platelet-specific proteins in patients with transient ischemic attacks. (Effects of anti-platelet drugs).

Levels of beta-thromboglobulin and platelet factor 4 in 46 patients with transient ischemic attacks and the influence of treatment with dipyridamole or aspirin plus dipyridamole were evaluated. Patients not receiving therapy showed levels of beta-thromboglobulin significantly higher than controls. However, patients taking only dipyridamole showed values of beta-thromboglobulin significantly lower than untreated patients or those taking aspirin plus dipyridamole. No significant difference was observed with regard to platelet factor 4 between the patients.

Adult↗
PubMedDate not supplied

Assessment of inter-observer differences in the Italian multicenter study on reversible cerebral ischemia.

A standardized protocol was used for duplicate examination by two neurologists of the clinical history and neurological signs in 55 patients with reversible cerebral ischemia. One trained examiner from each of eight clinical centres involved in the Italian Cooperative Study on reversible cerebral ischemia participated in this research. Duplicate examination were compared in order to evaluate the percentage of agreement achieved in the responses. Several discrepancies relating to either historical data or neurological signs were detected. Possible causes of this disagreement are discussed. The inter-observer differences appear to be an important problem to be faced in cooperative studies on reversible ischemic attacks. The purpose of the study was to estimate these differences in the attempt to increase the degree of agreement by repeated training sessions and discussion between the different examiners. These efforts are needed to improve the quality of clinical investigations on reversible cerebral ischemia and to increase the validity of their results.

Evaluation Studies as Topic↗
PubMedDate not supplied

The Italian Multicenter Study of reversible cerebral ischemic attacks: IV--Blood pressure components and atherosclerotic lesions.

Utilizing the initial BP assessment in the 462 patients who entered the Italian Multicenter Study of reversible cerebral ischemia, an analysis of the effect of each BP component in respect of presence, extent and severity of atherosclerotic lesions, as displayed by angiography, was carried out separately for lesions located at either intra- or extracranial level. In a multivariate statistical model, among the following variables: sex, age, systolic BP, diastolic BP, cholesterol and smoking, systolic BP was found the best predictor of extent and severity of atherosclerotic lesions at extracranial level. None of the same variables was predictive of the severity of intracranial atherosclerosis. The results of this clinical study may confirm the indication, coming from physiopathologic observations, of a predominant role of systolic hypertension in the process of maintenance and acceleration of atherosclerosis in the large pre-cerebral arteries.

Age Factors↗
PubMedDate not supplied

Italian multicenter study on reversible cerebral ischemic attacks: VI--Prognostic factors and follow-up results.

A total of 462 patients (mean age 52 years) affected by reversible focal ischemic attacks (RIAs) were followed prospectively in 8 neurologic institutions in Italy for 4 years. All cases were evaluated with a cerebral angiography and 21% of angiograms were normal. At the end of the follow-up period the cumulated probability for death, stroke, cardiac event and new RIA was respectively 7%, 8%, 3% and 36%. The predictive value of the baseline characteristics of this series was evaluated by a multifactorial analysis which showed that RIA and stroke (specific cerebrovascular risk) were more likely to develop in patients with a history of more than one RIA and in those in whom multiple vascular territories were involved. Moreover, previous myocardial infarction, intermittent claudication, angina pectoris, time elapsed since the first attack, and duration and severity of the attack itself were independently associated with general cardiovascular risk (death, stroke and myocardial infarction). We conclude that predictive factors, and thus also pathogenetic mechanisms, may be different for general cardiovascular risk and specific cerebrovascular risk in RIA patients.

Adult↗
PubMedDate not supplied

[EEG in transient ischemic attacks (author's transl)].

60 patients under 65 years of age with one or more episodes of reversible ischemic attacks lasting less or more than 24 hours (T.I.A. or R.I.N.D.) were studied. Each patient had a complete clinical assessment and an EEG, followed by an arteriogram. 35 patients had an EEG activation with digital carotid compression. EEG abnormalities were present in 26 cases while 34 patients had normal records. No correlation was found between EEG abnormalities and arteriographic alterations. EEG activation by digital carotid compression is a valuable hemodynamic test but cannot necessarily indicate a controlateral carotid artery occlusion.

Adult↗
PubMedDate not supplied

[Ophthalmodynamometry in transitory cerebral ischemic episodes].

The authors examine the diagnostic accuracy of ophthalmodynamometry in detecting extracranial internal carotid artery stenosis. 58 patients with T.I.A.s or R.I.N.D.s are studied. The test, compared with angiography, is positive only in 50% of patients presenting unilateral internal carotid artery occlusion.

Carotid Artery Thrombosis↗
PubMedDate not supplied

Regional cerebral blood flow compared to angiography in ischemic cerebrovascular diseases.

Regional cerebral blood flow determination, following post-angiographic intracarotid injection of 133Xenon, was performed in 11 patients with transient (T.I.A. - R.I.N.D.) or established (Stroke) cerebrovascular disorders. The regional cerebral perfusion rate of the grey matter was compared with angiographic data. There was a good correlation between angiographic abnormalities and regional cerebral perfusion rate disturbances. The Authors emphasize the presence of regional cerebral perfusion rate disturbances (not shown by angiography) even some time after transient ischemic episodes.

Adult↗