[Identification and digital simulation of intravenous infusion of indocyanine green in a healthy subject (author's transl)].
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Adult↗
Biomedical subjects
L Dedík
Publications and source records attributed to L Dedík.
[Identification of the process of plasma clearance of indocyanine green by an adaptive cybernetic model (author's transl)].
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Biliary Tract↗
Computer-based methods for measurement, recording and modeling vessel responses in vitro: a pilot study with noradrenaline.
This paper reports the first results of an ongoing methodological pilot study aimed at designing techniques for the automatic measurement and digital recording of vessel responses to biologically active substances under in vitro conditions and for the mathematical modeling of the underlying processes. The techniques presented in this pilot study allowed us to determine model-based estimates of the parameters characterizing vasoconstrictor responses, i.e., the vessel sensitivity parameter, the mean time of vasoconstrictor response and the rate constant of vessel relaxation. The given parameters are not dependent on doses of biologically active substances, provided that the underlying processes satisfy the principle of superposition. Use of these techniques is shown in the classic study of vasoconstrictor responses to noradrenaline in the rat renal artery.
Animals↗
Determination of analytical form of system weighting function.
This paper presents the determination of the analytical form of the weighting function of the three following complex multicomponent systems: 1) the system describing human pharmacokinetics of pentacaine after oral administration; 2) the system describing the hepatal elimination of indocyanine green in pig, and 3) the system describing the fate of indocyanine green in human esophageal varixes. The determination of the weighting function is based on the system transfer function and the technique of the partial-fraction inversion.
Administration, Oral↗