PubMed Health⌕ Search

Biomedical subjects

L Devilla

Publications and source records attributed to L Devilla.

49 records · Page 3Linked to original sources
PubMed1976

Effect of metroclopramide on serum prolactin levels in humans.

The effect of acute and chronic administration of metoclopramide on serum prolactin levels in normal subjects was studied. Metoclopramide 10 mg i.v. induced a prompt rise in serum prolactin levels in all subjects. At 180 min the levels remained high. Prolactin levels were markedly elevated during a 5 day course of treatment with metoclopramide in six subjects. It is suggested that metoclopramide could be used in the functional exploration of the hypothalamic-pituitary axis.

Adult↗
PubMed1976

Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathway.

A single dose of pyridoxine (300 mg iv) produced significant rises in peak levels of immunoreactive growth hormone GH and significant decrease of plasma prolactin PRL in 8 hospitalized healthy subjects. Serum glucose, luteinizing hormone LH, follicle stimulating hormone FSH and thyrotropin TSH were not altered significantly. In addition, in 5 acromegalic patients who were studied with both L-dopa and pyridoxine, inhibition of GH secretion followed either agent in a similar pattern. These data suggest a hypothalamic dopaminergic effect of pyridoxine.

Acromegaly↗
PubMed1976

Growth hormone and prolactin release in acromegalic patients following metergoline administration.

In six acromegalite patients oral administration of 4 mg of metergoline, an antiserotonin agent, produced a fall in plasma growth hormone (GH) and prolactin (PRL) concentrations. In the same patients this inhibitory effect was observed after administration of dopaminergic drugs, L-Dopa and 2-Br-alpha-ergocryptine. Both GH and PRL levels remained suppressed during a 6 day course of treatmnt with metergoline. These results are consistent with the hypothesis that the inhibitory effect of netergoline on GH and PRL release is determined by inactivation of serotonin receptors in the hypothalamus or at the pituitary.

Acromegaly↗
PubMed1976

Plasma prolactin response to L-dopa TRH and metaclopramide in thyrotoxicosis.

The plasma PRL repsonse to synthetic TRH, L-dopa and metaclopramide was evaluated in patients with thyrotoxicosis. A PRL response similar to thtaclopramide,while no PRL response was observed after TRH. When the TRH-test was repeated after treatment, all patients showed a normal increment in plasma PRL. This data suggests that, in thyrotoxicosis, PRl response to TRH only is impaired, but PRL can be suppressed by L-dopa or released by metaclopramide notwithstanding the elevated values of thyroid hormone levels.

Female↗
PubMedDate not supplied

Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man.

The effect of pirenzepine, a muscarinic receptor blocker which does not cross the blood brain barrier, on basal and TRH-stimulated prolactin (PRL) secretion in normal subjects was studied. Administration of 75 mg oral pirenzepine had no effects on prolactin levels in male subjects whereas it significantly reduced prolactin in females. No effect on TRH induced prolactin secretion was observed.

Adult↗
PubMedDate not supplied

Morphological evaluation of the conjunctiva and the trabecular meshwork incubated with Proline-3H.

It is well known that the trabecular meshwork is a complex structure in the shape of collagen and like-elastic fibers dipped in amorfous matrix. Previous researches have been showed that in the glaucoma disease there is a sclerosis in the lamellae of the trabecular meshwork and an increase in extracellular material. In order to add informations to complex and highly organized trabecular meshwork and its role in the glaucoma disease, 12 surgical specimens of trabecular meshwork and conjunctival tissue from patients suffering from chronic simple glaucoma and undergone medical therapy have been examined. The fragments have been immediately incubated with Proline 3H for 45 minutes; after this period they have been fixed and included. The results have been showed the presence of the fibroblast cells engaged to pick up radioactive Proline. The collagen synthesis has been happened in the trabecular meshwork and in this study there is not demonstration of collagenic material coming from surrounding structures.

Conjunctiva↗