Biomedical subjects

L Dodds

Publications and source records attributed to L Dodds.

24 records · Page 2Linked to original sources

PubMed1993

Risk factors for renal cell carcinoma: results of a population-based case-control study.

For a case-control study of risk factors for renal cell carcinoma, a mailed questionnaire was used to collect data on 518 cases and 1,381 population-based controls in Ontario, Canada. Active cigarette smoking increased risk twofold among males (odds ratio estimate [OR] = 2.0, 95 percent confidence interval (CI) = 1.4-2.8) and females (OR = 1.9, CI = 1.3-2.6). Passive smoking appeared to increase risk somewhat among nonsmokers (males: OR = 1.6, CI = 0.5-4.7; females: OR = 1.7, CI = 0.8-3.4). A high Quetelet index (QI) was associated with a twofold increase in risk in both sexes, although this was based on reported weight at age 25 years for males (OR = 1.9, CI = 1.2-3.1) and five years prior to data collection for females (OR = 2.5, CI = 1.4-4.6). Diuretic use was associated with significantly increased risk among females, but not among males. Phenacetin use increased risk, while acetaminophen use was not associated with altered risk, although few subjects used either compound. Multiple urinary tract infections increased risk, but only significantly in females (OR = 1.9, CI = 1.2-2.9). Our data indicate the need for further exploration of passive smoking and diuretics as risk factors, as well as elucidation of mechanisms by which high lifetime QI and frequent urinary-tract infections might increase risk of this cancer.

Adult↗

PubMed1992

The effect on response rates of offering a small incentive with a mailed questionnaire.

To determine whether response rates to a mailed questionnaire sent to population control subjects could be increased through offer of a small incentive, half of the control subjects (n = 477) in a case-control study of renal cell carcinoma were randomly selected to receive a contact letter offering a lottery ticket if a completed questionnaire was returned; the remaining subjects (n = 477) received the same letter but with no mention of a lottery ticket. Overall response rates did not differ between the two groups (72.6% versus 74.4%), although a higher percentage of those offered a lottery ticket responded without follow-up (24.4% versus 18.5%). Binomial regression modeling of the effect of the lottery ticket offer, sex, age, and percent of urban dwellers on response indicated a significant effect only for percent of urban dwellers, the rate of response increasing with a decreasing percentage of urban dwellers. The effect of sex was of borderline significance (P = 0.05), with females having the higher rate of response.

Adult↗

PubMed1987

Peripheral hepatic arterial embolization with crosslinked collagen fibers.

Hepatic artery embolization with a nonimmunogenic, crosslinked microfibrillar collagen preparation (Angiostat, Collagen for Embolization, Target Therapeutics, Los Angeles, CA) was studied in mongrel dogs. Flow-directed technique was used to achieve complete distal arterial occlusion. Serial liver function evaluation demonstrated marked alterations at 48 to 72 hours, partial correction at one week, and resolution of abnormalities by one month. Restoration of large vessel blood flow was angiographically demonstrable at one week. Follow-up arteriograms showed no persistent arterial occlusion. Collagen was demonstrated in vessels of 20 to 250 micron. Recanalization was achieved by migration of endothelial cells around the collagen, development of a new vascular channel within an endothelial cell cleft, and subsequent complete removal of the collagen over a three- to four-month period. Three months after embolization with a single dose, normal hepatic vascular and tissue anatomy and hepatic function were restored completely. Repeated embolization at two weekly intervals was well tolerated.

Animals↗

PubMed1986

A population-based study of lung cancer incidence trends by histologic type, 1974-81.

All incident cases of microscopically confirmed lung cancer diagnosed between 1974 and 1981 in western Washington State were identified through the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute, Bethesda, MD. The incidence of lung cancer by histologic type was studied in relation to time, with age, sex, and stage of disease at diagnosis being taken into account. Overall and within each sex, the incidence of adenocarcinoma has increased significantly since 1974. The rate of increase has been higher among females (86% increase) than among males (54% increase), with most of the increase in both sexes being among those over age 65 years with distant or unstaged disease at diagnosis. Similar patterns were not observed for squamous cell carcinoma. The potential effects of changes in diagnostic and pathology practice during the study period in producing these results were explored, and etiologic implications of the observed increase in adenocarcinoma were discussed.

Adenocarcinoma↗

PubMedDate not supplied

Congenital anomalies and other birth outcomes among infants born to women living near a hazardous waste site in Sydney, Nova Scotia.

Using data from the Nova Scotia Atlee Perinatal Database, rates of adverse birth outcomes were compared among residents of Sydney, Nova Scotia and residents of Cape Breton County, Nova Scotia (excluding Sydney) with birth outcomes among residents of the rest of Nova Scotia. There was a small but statistically significant increase in the rate of major congenital anomalies in Sydney (2.8%) compared to the rest of Nova Scotia (2.3%) (adjusted RR = 1.25, 95% CI = 1.04-1.51). Rates of anomaly sub-groups were consistently elevated in Sydney compared to the rest of Nova Scotia, but most were not statistically significant. For the most part, the increased rates of congenital anomalies observed among residents of Sydney were not evident in the neighbouring community. Since Sydney and the rest of Cape Breton County share a similar risk factor and socio-demographic profile, other factors likely explain the increased rates observed in Sydney.

Congenital Abnormalities↗

PubMedDate not supplied

Cancer incidence in an urban community: an historical cohort study.

This historical cohort study tested the hypothesis that residents of an industrialized urban community were at higher risk of cancer than residents of a comparable, but non-industrialized, community. The exposed (C1) and the unexposed (C2) cohorts resided in their respective neighbourhoods between 1952 and 1956. All incident cancers were identified through linkage with the Ontario Cancer Registry for 1964-1982. Cancer incidence rates in the two cohorts were 7.0 and 7.3 per 1,000 person-years, respectively. Relative risk estimates for all cancers, lung cancer and cancers associated with environmental exposure, were not significantly different from 1.0. Only colorectal cancers were significantly more frequent in the C1 than the C2 cohort, and these only in one sub-analysis. Overall, we conclude that if there was increased risk of cancer related to environmental pollution in the industrially exposed community, it was less than a two-fold increase.

Adolescent↗