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Biomedical subjects

L Doering

Publications and source records attributed to L Doering.

6 recordsLinked to original sources
PubMed2001

Immunohistochemical localization of a 40-kDa catecholamine regulated protein in the nigrostriatal pathway.

The 40 kDa catecholamine regulated protein (CRP40) has been shown to covalently bind catcholamines in vitro. In this report we provide evidence for CRP40 localization in the dopaminergic nigrostriatal pathway. Using double labeling immunohistochemistry, CRP40 was detected in the majority of substantia nigra pars compacta and striatal neurons. In addition, CRP40 was also present in tyrosine hydroxylase immunonegative neurons. Subcellular localization of CRP40 shows a predominant nuclear presence in striatal neurons while distinct outlining of the nucleus and cell body staining were seen more readily in nigral neurons. These findings suggest that CRP40 may have multiple functions in a variety of neurons in the central nervous system.

Animals↗
PubMed1995

Predictors of between-method differences in cardiac output measurement using thoracic electrical bioimpedance and thermodilution.

OBJECTIVES: To evaluate the usefulness of transthoracic electrical bioimpedance in trending changes in cardiac output after cardiac surgery, and to identify predictors of differences between cardiac output measured by thermodilution and transthoracic electrical bioimpedance methods. DESIGN: Prospective repeated-measures study. SETTING: University-affiliated tertiary care center. PATIENTS: Thirty-four adult patients undergoing elective cardiac surgery with routine pulmonary artery catheter placement. INTERVENTIONS: Simultaneous paired cardiac output measurements by transthoracic electrical bioimpedance and thermodilution were made at four time points: within 2 hrs of intensive care unit (ICU) admission; when the patient reached a normothermic temperature; after extubation; and 24 hrs after ICU admission. MEASUREMENTS AND MAIN RESULTS: Mean measurements by each method over time did not differ, except at ICU admission, when compared by repeated-measures analysis of variance. For each time point, bias and precision between methods were calculated. Bias calculations ranged from 0.02 to 0.21 L/min/m2. Precision calculations ranged from 1.06 to 1.52 L/min/m2. Predictors of between-method differences identified by a multiple regression model of hemodynamic variables were: increased systemic vascular resistance index, decreased mean arterial pressure (MAP), and the presence of atrial or ventricular pacing. CONCLUSIONS: While mean postoperative cardiac output measurements did not differ by method over time, agreement between transthoracic electrical bioimpedance and thermodilution methods was poor in the immediate postoperative period, with precision calculations indicative of clinically significant differences. Increased systemic vascular resistance index and decreased MAP were predictive of larger between-method differences.

Aged↗
PubMed1992

Power and knowledge in nursing: a feminist poststructuralist view.

This article explores the concepts of power and knowledge from two philosophical perspectives, the feminist and the poststructuralist, and examines their application to nursing knowledge and nursing science. Principles of poststructuralist and feminist philosophies are presented. The role of the nursing-medicine power relation in the development of nursing knowledge and the interaction of gender issues in that relation are reviewed in the context of nursing history. Both past and current mechanisms that contribute to the maintenance of the nursing-medicine power relation are discussed.

Cognition↗
PubMed1990

Recruitment and retention: successful strategies in critical care.

Recruitment and retention of critical care nurses is a major concern for nurse managers. Factors that affect recruitment and retention are management style, perceptions of isolation, stress, and burnout. Decentralization, primary nursing, and clinical advancement programs are strategies that allow nurses to participate in decision making at the unit level and to be recognized for their individual contributions. The application of these strategies to a cardiac surgery intensive care unit is presented.

Burnout, Professional↗
PubMedDate not supplied

Comparisons of cardiac output in supine and lateral positions.

Cardiac output was measured by thermodilution in 51 adult postcardiac surgical patients using three positions, supine, right lateral, and left lateral, each with 20 degrees backrest elevation. Measurements were taken 4 to 24 hours (M = 10.58) after surgery. Mean cardiac output was significantly different in the three positions, p = .03. This difference resulted from changes in stroke volume, p = .004, rather than changes in heart rate, p = .12. The largest variation occurred between cardiac outputs measured in the supine position and those measured in the left lateral position. Patients at greatest risk for variations in cardiac output with lateral postural change were those with a cardiac index less than 2.3 L/min/m2, those in whom the time elapsed since surgery was less than 12 hours, and those receiving either vasoactive drugs or mechanical ventilation. These results suggest that nurses need to measure cardiac output using a supine position to control for physiological changes that may occur with lateral postural change.

Adult↗