Biomedical subjects
Publications and source records attributed to L Dolberg.
An alveolar soft-part sarcoma of the uterine cervix observed in a 26-year-old woman is described. One year after extended radical hysterectomy there was no evidence of tumor recurrence. To the best of our knowledge, this is the second reported case of alveolar soft-part sarcoma arising in the female genital tract and the first description of this tumor in the uterine cervix.
Measurement of serial aspartate aminotransferase (AST) and alanine aminotransferase (ALT)--formerly GOT and GPT--in both serum and urine, were carried out in rats with hepatocellular injury induced by ingestion of carbon tetrachloride. Contrary to the accepted clinical observations, the AST was initially higher than the serum ALT. Also, the clearance of AST from blood to urine was more rapid than that of ALT. This difference in enzyme excretion resulted in a more persistent elevation of ALT than of AST in the serum after hepatic injury. The persistent elevation of serum ALT correlates well with the timing of the clinical observation of higher ALT in patients with hepatitis.
A rare case of metastatic melanoma to the palatine tonsils was presented. The patient had no symptoms, and the metastatic oral lesion was discovered on routine examination.
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A previous survey of the seroprevalence of the herpes virus type 2 (HSV-2) infection in Israel provided us with an opportunity to study a) the prevalence of human papillomavirus (HPV) 16/18 in selected groups of women; b) the correlation between the infection with HSV-2, HPV-16/18 and Papanicolaou (PAP) pathology; and c) to identify groups of women who might benefit from routine PAP screening. Four different population groups of women aged 17-60 years were studied: groups 1 and 2 comprised healthy women government employees and kibbutz and moshav residents, respectively, and groups 3 and 4 comprised Jewish and non-Jewish women with gynecological complaints. In women without gynecological problems the prevalence of HPV-16/18 was 1.8% in group 1 and 0% in group 2. The prevalence was several-fold higher in the Jewish and non-Jewish gynecological clinic groups, 9% and 12%, respectively. There was no correlation between the prevalence of HSV-2 antibodies and HPV-16/18 infection in women without gynecological problems. One of the 692 women studied had markers of both infections. The very few cases of cervical intraepithelial neoplasia (CIN) II and CIN III occurred in women who were negative for HSV-2 and HPV-16/18 infection. Thus from our limited study, it is not possible to define any group of healthy women who might benefit from continuous PAP smear screening for cervical cancer.