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Biomedical subjects

L E Alekseeva

Publications and source records attributed to L E Alekseeva.

14 recordsLinked to original sources
PubMed2005

Neuroprotective effect of cytoflavin during compression injury of the spinal cord.

Cytoflavin normalized energy metabolism, decreased the intensity of lipid peroxidation, and reactivated the antioxidant system in the spinal cord of rats with compression injury at the level of Th10-Th11. The neuroprotective effect of the test preparation manifested in normalization of hindlimb motor function and decrease in mortality rate of animals with spinal cord injury. Neuroprotective activity of cytoflavin was higher than that of Cerebrolysin.

Animals↗
PubMed2004

Effects of cytoflavin and neuronol on morphological changes in the brain and survival of rats with ischemic disturbances in cerebral blood flow.

Cytoflavin and neuronol produce vasoactive and neuroprotective effects in rats with cerebral ischemia. Vasoactive activity of neuronol was higher than that of cytoflavin. These differences were most pronounced at the level of microcirculation. Test preparations were equally potent in producing the neuroprotective effect. Cytoflavin and neuronol markedly decreased the mortality rate of animals. Over the first 6 h of ischemia the relative effectiveness of cytoflavin was higher than that of neuronol. However, neuronol exceeded cytoflavin in the relative effectiveness during the follow-up period (days 1-21).

Animals↗
PubMed1990

[Structure of the chromophore fragment of copsomycin].

The chromophore moiety of the copsomycin molecule was isolated in the form of dimethyl ether as an individual substance from the products of antibiotic acid hydrolysis. Physicochemical properties of the chromophore were studied. UV, 1H and 13C NMR, mass spectrometry and elementary analysis showed that the copsomycin molecule moiety was identical to the chromophore moiety of the molecule of multiomycin or nosiheptide.

Anti-Bacterial Agents↗
PubMed1986

[Isolation and study of the biological properties of substances stimulating levorin biosynthesis in a mixed actinomycete and yeast culture].

Active components responsible for increased synthesis levels of levorin, a polyenic antibiotic in mixed cultures of an actinomycete and a yeast-like fungus C. tropicalis were isolated from the fermentation broth. Component I identified as succinic acid increased the levels of the antibiotic production by 40-50 per cent. Component II found to be lactic acid increased the antibiotic production levels by 20 per cent. Component III, a mixture of nonidentified substances of the amine nature stimulated biosynthesis of levorin by 20-25 per cent. Addition of a mixture of succinic acid and N-methyl glucosamine to the nutrient medium provided increase of the antibiotic activity of the fermentation broth up to 175-185 per cent as compared to the control.

Antifungal Agents↗
PubMed1985

[Action of biologically active compounds on kanamycin inactivation by resistant microorganisms].

Products of kanamycin inactivation were identified chromatographically and radiometrically in E. coli 154, K. aerogenes 600 and P. vulgaris 7470. It was shown that the efficiency of kanamycin inactivation in the membrane fraction was 2 times higher than that in cytosol. A decrease in the culture resistance to kanamycin was observed, when the antibiotic was used in combination with the main proteins or phosphonites: a 16-64-fold decrease in the kanamycin MIC. Comparison of the data on the efficiency of the inactivation inhibition by intact cells and in acellular extracts suggests that the effect of protamine on this process is mediated by the cell membrane, whereas phosphonites can also directly interact with the enzymes inactivating the antibiotic.

Drug Resistance, Microbial↗
PubMedDate not supplied

[Cycloferon in treating duodenal ulcers in rats].

The possibility of using cycloferon (interferon inductor) for a complex treatment (in combination with the main drug solcoseryl possessing pronounced therapeutic properties) of duodenum ulcers was experimentally studied in male rats. The experiments showed a considerable difference in the interferon status of animals with model duodenum ulcers treated with cycloferon, solcoseryl, their combination, and placebo (control). The healing effect of solcoseryl administered in combination with cycloferon exceeded that of each component administered separately.

Acridines↗
PubMedDate not supplied

[Use of cytoflavin for correction of complications of myocardial infarction].

The possibility of using a combined preparation cytoflavine was studied on rats with myocardial infarction induced by coronary artery occlusion. The drug produces a positive action upon the energy exchange and the lipid peroxidation process and normalizes functioning of the system of antioxidant protection of the ischemized myocardium. Cytoflavine treatment led to a more favorable course of ischemic and necrotic processes and optimum organization of the necrosis zones.

Animals↗
PubMedDate not supplied

[Neuroprotective effect of cytoflavin in closed craniocerebral trauma].

The efficacy of a complex preparation cytoflavin was studied on rats with a model of closed craniocerebral trauma. Cytoflavin produced normalization of the energy exchange, lipid peroxidation, and antioxidant system functioning in nervous tissues. The treatment significantly reduced the degree of posttraumatic edemation in the brain. The cerebroprotective action of cytoflavin was somewhat superior to the effect of the reference drug solcoseryl.

Animals↗
PubMedDate not supplied

[Antiamnesic effect of cytoflavin and neuronol in rats with ischemic impairment of cerebral circulation].

The antiamnesic action of the new complex preparations cytoflavin and neuronol was studied in rats with a cerebral ischemia model, tested for the passive avoidance conditioned reflex. The neuroprotector effect of drugs was determined by morphological methods. Both cytoflavin and neuronol reduced neuronal damage in the pyramidal layer of the hippocampus and prevented the development of amnesia during the entire period of cerebral ischemia (3-21 days). Both drugs also improved horizontal locomotor activity and emotional reactions of animals in the open field test.

Amnesia↗
PubMedDate not supplied

[Nature of the stimulating substances found in the vital activity products of yeastlike fungi].

The cultural broth of Candida tropicalis was shown to contain an active compound which stimulated the synthesis of levorin, a polyene antibiotic Succinic acid was found to stimulate the antibiotic synthesis. The stimulating effect of the active compound increased in proportion to the content of succinic acid in it and became maximal at the same concentration of succinic acid as in a pure preparation. However, succinic acid was not an only compound responsible for the elevated synthesis of the antibiotic since the biostimulating effect was higher than that of pure succinic acid.

Bacteria↗