The distribution of calcium in hypoxic cat hearts: the effect of beta 1-blockade.
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Adrenergic beta-Antagonists↗
Biomedical subjects
L E Bailey
Publications and source records attributed to L E Bailey.
Changes in myocardial calcium and E-C coupling associated with failure and ouabain treatment.
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Animals↗
Prevention of relaxation by lanthanum in the kitten heart.
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Animals↗
Calcium pools in excitation-contraction coupling in the cat heart.
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Action Potentials↗
Steady state multiplicity and stability of enzymatic reaction systems.
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Enzymes↗
Uncoupling of excitation from contraction by nickel in cardiac muscle.
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Animals↗
Two functionally distinct calcium pools in the excitation-contraction coupling process.
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Animals↗
Calcium movement during contraction in the cat heart.
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Animals↗
Correlation of the subcellular distribution of digoxin with the positive inotropic effect.
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Aldosterone↗
The effect of ouabain on the distribution of calcium in the cat heart.
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Animals↗
Role of the sugar transport system in the positive inotropic response to digitalis.
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Animals↗
The effect of ouabain on the washout and uptake of calcium in the isolated cat heart.
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Animals↗
The effect of gas-perfusion on myocardial contractility and the inotropic effect of ouabain.
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Animals↗
The effect of insulin on the subcellular distribution and the inotropic effect of 3H-digoxin in the guinea pig heart.
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Animals↗
The effect of heart rate on the content of calcium in a pool associated with the maintenance of contractile force.
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Animals↗
Increase in the rate of onset of the inotropic response to ouabain due to insulin.
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Animals↗
Effect of ouabain on cardiac 45Ca kinetics measured by indicator dilution.
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Animals↗
Correlation of contractile force with a calcium pool in the isolated cat heart.
The relationship between cellular calcium (Ca) stores and isometric contractile force was investigated in isolated, gas-perfused cat hearts. The hearts were preperfused for approximately 5 min with substrate-free Krebs solution modified to contain 0, 1.25, 2.5, 5.0 or 10.0 mEq/liter Ca, gas-perfused for up to 120 min, and then perfused with zero-Ca Krebs solution. Contractile force and [Ca] in the effluent fluid were measured. Our results indicate that: (a) The washout of Ca was characteristic of a three compartment system, (b) A Ca compartment directly associated with muscle contraction was identified by correlation of the rate of Ca washout with the rate of decay of contractility (r = 0.79). (c) Ca content in the compartment was correlated with contractile force (r = 0.77). (d) Contractile force and the Ca content of the compartment which was correlated with contractility approached a steady state during 120 min of gas perfusion.
Animals↗