Biomedical subjects

L E Eizember

Publications and source records attributed to L E Eizember.

8 recordsLinked to original sources

PubMed1996

Outcome of the contralateral hip following total hip arthroplasty for osteoarthritis.

One thousand one hundred and sixteen patients who underwent unilateral total hip arthroplasty osteoarthritis between 1970 and 1980 were examined for development, progression, and total hip arthroplasty in the contralateral joint. At the time of the original surgery, 452 patients were diagnosed with bilateral osteoarthritis and 664 had a normal contralateral hip. The probability of osteoarthritis progressing in the contralateral joint is 78.6% at 10 years, with the chance of arthroplasty being 53.8%. The probability of a hip diagnosed as normal developing osteoarthritis is 36.5% at 10 years, with an 8.3% chance of requiring total hip arthroplasty.

Adult↗

PubMed1995

The effect of heterotopic bone formation on prosthetic loosening after total hip replacement.

Seven hundred thirty-two total hip replacements performed from 1970 to 1980 were evaluated for the degree of heterotopic bone formation postoperatively and its effect on long-term mechanical loosening. There were 231 Charnley total hip replacements, of which 152 had no heterotopic bone formation, 58 had Grade 1 formation, and 21 had Grade 2 or 3 formation. Among the 123 Mueller total hip replacements, 98 had no heterotopic bone formation, 19 had Grade 1 formation, and 6 had Grade 2 or 3 formation. For the 378 T-28 total hip replacements, there were 305 with no heterotopic bone formation, 59 with Grade 1 formation, and 14 with Grade 2 or 3 formation. Survival analyses using the definition of failure as loosening, fracture, or revision of the acetabulum or femoral components were constructed. There was no correlation between mechanical loosening, fracture, or revision of the total hip replacement and any degree of heterotopic bone formation.

Arthritis, Rheumatoid↗

PubMed1991

Bioassay for siderophore utilization by Candida albicans.

A convenient plate assay which is sensitive to medium pH has been developed to evaluate potential siderophores of Candida albicans. Adding a siderophore to a filter paper disk on chemically defined Lee's agar (final pH 7.2) seeded with the test strain reversed the growth inhibitory effects of the supplemented (25-100 micrograms/ml) iron chelator ethylenediaminedi(o-hydroxyphenylacetic acid), to provide a zone of growth stimulation. This bioassay has been used to demonstrate the structure-activity relationships of ferrichrome and several water-soluble hydroxamate peptide building blocks of this natural siderophore. Of all compounds so evaluated, ferrichrome exhibited the best activity.

Candida albicans↗

PubMed1991

Revision total knee arthroplasty. A survival analysis.

The results of revision total knee arthroplasty (TKA) have been documented reasonably well in the literature. It is notable, however, that none of these reports have used the technique known as survival analysis to compare virgin and revision arthroplasties. This technique has an advantage over conventional analyses because it does not exclude patient data for inadequate follow-up study or patient death. In this study, survival analysis was applied to 37 revision TKAs performed exclusively by the senior author. With failure defined as removal of the prosthesis, revision surgeries experienced a 97.0% survival rate at 6 years. The secondary arthroplasty demonstrated a significantly lower survival rate than the index procedure over a period of approximately 6 years.

Actuarial Analysis↗

PubMed1991

Trochanteric fixation by cable grip in hip replacement.

We used the stainless steel cable grip system described by Dall and Miles in 1983 to fix trochanters in 40 hips after total arthroplasty with trochanteric osteotomy. The cable broke in 32.5% of the hips; the trochanter failed to unite in 37.5%. Significantly more cables broke when placed inside the femoral canal than when the cable was placed round the femoral shaft (58% as against 9.5%, difference p less than 0.01). The high incidence of breakage may have resulted from contact between the stainless steel cable and the titanium prosthesis, from the acute angulation, or because of the lower fatigue strength of stainless steel. Better results have been obtained using cables with a higher fatigue strength, passed outside the proximal femur.

Adult↗

PubMed1991

The effect of miscellaneous invasive procedures on subsequent total knee arthroplasty.

Invasive orthopedic procedures were performed on 112 joints that underwent total condylar knee arthroplasty between November 1975 and February 1987. These knees were divided into six categories based on the most traumatic surgical procedure the patients had experienced. The six classifications were total knee arthroplasty, proximal tibial osteotomy, fracture fixation, patellectomy, arthroscopy, and debridement. Each group of knees was compared with the 579 primary arthroplasties performed during the same time period. The only group in which results were significantly less favorable than those of the virgin joints was the previous total arthroplasty category. All other surgical classification groups had knee scores, radiolucency frequencies, and ranges of motion comparable with those of the primary replacement surgeries. When surgical techniques are modified to insure proper soft tissue alignment, patients who have undergone previous invasive procedures on their knees can expect highly favorable results from total joint arthroplasty.

Arthroscopy↗

PubMed1991

The survival of total knee arthroplasty in patients with osteonecrosis of the medial condyle.

The results of total knee arthroplasty in patients with osteonecrosis of the medial femoral condyle were examined using Kaplan-Meier survival analysis. The study included 32 osteonecrotic knees with an average final follow-up examination of 3.9 years. For comparison, 63 osteoarthrotic knees with an average final follow-up examination of 4.6 years were also analyzed. The survival rates were calculated using four distinct categories of failure: (1) revision, (2) revision or radiolucency, (3) revision, radiolucency, or pain, and (4) pain. On the basis of pain relief alone, the five-year postoperative success rate was 82% for osteonecrosis (eight knees) and 90% for osteoarthrosis (27 knees), with no significant statistical difference between the two groups.

Aged↗

PubMed1990

Survival of a cemented porous-coated prosthesis.

Porous-surfaced femoral components were approved by the United States Food and Drug Administration for implantation with polymethyl methacrylate cement in total hip arthroplasty. The ability of porous coating to prevent loosening of prostheses in vivo has not been reported in the literature previously. This study compared the radiographic and clinical success of two structurally similar prosthetic designs, one of which incorporates a porous coat. Kaplan-Meier survival analysis showed no significant difference between the components (P greater than .05) when failure is defined as revision alone, radiolucency alone, or the combination of revision and radiolucency.

Aged↗