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L E Gedymin

Publications and source records attributed to L E Gedymin.

62 records · Page 4Linked to original sources
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[Mycobacteria in the development of periodontal foci of infection].

A total of 162 samples of material from the periodontal foci of infection were examined microbiologically and morphologically to detect mycobacteria and their biologically changed variants. The regularities of the pathologic process development in periodontal tissues of subjects without tuberculosis were found to fully conform to the current concept of a latent tuberculous infection. The periodontal foci of infection may be regarded as reservoirs of persistent mycobacteria, whose main form, L variant, was detected in 71.6% of cases. Clinical and morphologic manifestations of periodontitis depend on the stability of the persistent mycobacteria L forms.

Adult↗
PubMedDate not supplied

[The effect of antioxidants on the balance of proteinase-inhibitors system in the respiratory space of mice with pulmonary tuberculosis].

In three series of experiments generalized form of tuberculosis was simulated in 427 mice of CBA strain. After dissection of chest bronchoalveolar lavage was carried out and in the fluid obtained total content of protein, elastase-like and antitryptic activities were estimated. At the severe stage of the disease content of protein was increased 7-fold, antitryptic activity--5-fold and elastase-like activity--10-fold in the lavage. EDTA did not inhibit the elastase-like activity, i.e. the enzyme was derived only from neutrophils. All the patterns studied were unaltered after the animal treatment with alpha-tocopherol at a dose of 100 mg/kg (per os) within one or three weeks. In vitro incubation of preparations in presence of ascorbic acid at the final concentration of 0.01 M within 1 hr at 37 degrees caused a considerable (4-6-fold) activation of the antitryptic activity simultaneously with a distinct decrease in the elastase-like activity down to physiological values. The data obtained suggest that inactivation of the reactive centre of antiproteinases by means of products of free-radical oxidation appears to be mainly responsible for disbalance of proteinases-inhibitors in tuberculosis.

Animals↗
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[The x-ray morphological characteristics of the early manifestations of sarcoidosis].

The paper is devoted to an analysis of combined x-ray findings supplemented by CT findings in patients with sarcoidosis detected for the first time with early signs of this disease. A conclusion has been made that apart from lymph node enlargement, sarcoidosis is characterized by lung parenchymal changes which manifest themselves as symptoms of broncho-alveolitis. Characteristic x-ray symptom complexes are described. Roentgeno-semiotics of these changes were compared with the results of morphological investigation of transbronchial puncture specimens. Roentgenologically detectable changes showed good correlation with morphology findings. The authors have also emphasized the importance of morphological verification of this disease at early stages.

Adult↗
PubMedDate not supplied

[Comparative characteristics of the activity of proteolytic enzymes and their inhibitors in the lung tissue of guinea pigs during development of generalized and destructive tuberculosis].

Two series of experiments were carried out using 66 guinea pigs infected with tuberculosis. In the first experiment generalized tuberculosis was stimulated by means of subcutaneous administration of Mycobacterium tuberculosis H37RV strain at a dose of 0.0001 mg. In the second experiment destructive form of tuberculosis was developed after intrapulmonary administration of the bacteria (1 mg) followed by VCG vaccination. In both experiments the animals were divided into groups with spontaneous form of the infection and the group of animals treated with rifamycin and isoniazid. Total protein, elastolytic activity, cathepsins B and D, free antitryptic activity were estimated in lung homogenates. Generalized and destructive forms of tuberculosis were shown to induce an increase in content of soluble protein as well as in cathepsin D, elastolytic and antitryptic activities in tissues. Destructive form of tuberculosis was characterized by more than 4-fold increase in elastolytic activity and by a distinct activation of cathepsin B. The antibacterial drugs used affected only slightly the biochemical patterns studied in lung tissue.

Animals↗