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Biomedical subjects

L E Goldblum

Publications and source records attributed to L E Goldblum.

3 recordsLinked to original sources
PubMed1990

Hormonal replacement therapy: mammographic manifestations.

Anecdotal observation of mammographic changes in patients receiving hormonal replacement therapy prompted a retrospective review of a screening population of 1,500 consecutive patients. Thirty patients were identified who underwent mammography both before or after therapy and during therapy. The duration of hormonal replacement therapy ranged from 1 to 72 months (mean, 22.2 months). An increase in fibroglandular tissue was seen on the mammograms of five of the 30 patients (17%) receiving therapy. The mammograms from the remaining 25 patients (83%) showed no change. A proportion of women receiving hormonal replacement therapy will show increased tissue density at mammography. Awareness of this response should temper concern and, in the absence of suggestive anatomic changes, allow for serial, vigilant monitoring of these patients.

Breast↗
PubMed1988

Renal involvement in AIDS: sonographic-pathologic correlation.

Renal sonography was performed in 36 patients with clinical and/or laboratory evidence of AIDS, usually because of deteriorating renal function. In 15 patients, histopathologic specimens were reviewed to characterize renal pathologic changes underlying the sonographic findings. Sonographic evaluation included determination of renal size and cortical echogenicity according to a standard grading system. Pathologic specimens were evaluated for tubular and glomerular abnormalities. Sonography showed either normal-sized or enlarged kidneys with grade I cortical echogenicity in 13 patients (36%), grade II in three patients (8%), and grade III in five patients (14%). Fifteen patients (42%) had normal renal echogenicity. In addition to focal segmental glomerulosclerosis the pathologic examination showed different degrees of tubular abnormalities. Striking, irregularly dilated, infolded tubules with flattened epithelium and intratubular deposits of proteinaceous material, and sometimes cystlike formation involving the medulla and cortex, were seen in two patients with grade III kidneys, and mild dilatation of the tubules was seen in four patients with grade I disease. Moderate tubular dilatation was observed in one patient with grade I disease. No significant tubular abnormality was seen in one patient with grade I disease or in seven patients with normal renal echogenicity. Although glomerular changes contribute to the increase in renal echogenicity, we postulate that the main factors responsible for the increased echogenicity in AIDS nephropathy are the striking tubular abnormalities seen in these patients.

Acquired Immunodeficiency Syndrome↗