Biomedical subjects
Publications and source records attributed to L E Golitz.
A female infant was noted at birth to have severe skeletal anomalies of the right upper and lowere extremities. These anomalies were associated with an inflammatory linear verrucous epidermal nevus (ILVEN). Like the noninflammatory type of epidermal nevus, ILVEN may be a component of the epidermal nevus syndrome.
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Monocyte-macrophage function was studied in 14 patients with histologically confirmed mycosis fungoides. Three component parts of the monocyte-macrophage system were examined. Monocyte bacterial phagocytosis and bacterial killing were normal. However, a defect in directional mobility (chemotaxis) was found in patients with mycosis fungiodes (P less than .0025) when compared to 35 healthy controls. Defective chemotaxis was present regardless of disease stage or therapy. This defect in monocyte chemotaxis represents a previously unrecognized immune deficiency and may help explain the frequent infections found in patients with mycosis fungoides.
Erosive adenomatosis of the nipple is a rare, usually benign neoplasm of the major nipple ducts. Although morphologic features may distinguish it from Paget disease, histopathological differentiation is simple. Recognition of this tumor may spare needless mastectomy.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Dermatomyositis and variants of lupus erythematosus share histopathologic features which include liquefaction degeneration of the epidermal basal zone, melanin pigment incontinence, and the presence of colloid bodies. The pattern of epidermal changes and dermal inflammation help establish the correct diagnosis. Immunofluorescence microscopy of skin biopsies is useful in confirming the diagnosis.