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Biomedical subjects

L E Millikan

Publications and source records attributed to L E Millikan.

16 recordsLinked to original sources
PubMed1992

Vesiculobullous diseases with prominent immunologic features.

It may be very difficult to differentiate between the many bullous skin diseases. Clinical presentation and age of onset can sometimes be helpful. Consultation with a dermatologist may facilitate diagnosis and treatment. More often, information from skin biopsy and immunofluorescent studies, such as DIF, IIF, or split-skin DIF or IIF, is required to make the diagnosis. It is hoped that current investigative studies will elucidate the role of immunoreactants found within the dermoepidermal basement membrane zone in the pathogenesis of these blistering diseases.

Child↗
PubMed1992

An update on common skin diseases. Acne, psoriasis, contact dermatitis, and warts.

The therapeutic approaches to the five common skin problems described range from standard topical and systemic agents to newly introduced alternative medications and techniques. In acne, the type of lesion found on physical examination determines the severity of the disease and its subsequent treatment. When necessary, appropriate precautions must be taken before and during therapy. Fortunately, with the drugs available today, only the most extreme cases of acne should progress to the stage where physical and/or psychological scarring occurs. The number of therapeutic approaches to psoriasis, from steroids to UV light, pays testament to the difficulty in treating this cyclic disease. Until an effective and safe medication is developed, research is sure to continue. Sources of the antigen causing contact dermatitis are sometimes unusual, but the lesions have a characteristic appearance. Several topical and systemic agents are available. Patient education and prophylactic measures play an important role. Therapies for both venereal and nonvenereal warts are proliferating. The evolving understanding of viral oncogenesis in both types of warts promises that this will be an area of continued intense research in the next few years.

Acne Vulgaris↗
PubMed1992

Case report: myiasis--the botfly boil.

Cutaneous furunculoid myiasis arises from the infestation of skin or mucous membranes with dipterous larvae. Myiasis from the botfly Dermatobia hominis is a common parasitic disease of the tropics of Central and South America, and may present in the United States. With increasing travel by U.S. citizens, there is potential for increased occurrence; it is important to be able to accurately diagnose myiasis and differentiate it from entities with similar presentations, such as leishmaniasis. The authors describe four cases of myiasis from D. hominis infestation and review clinical features, differential diagnosis, and treatment.

Adult↗
PubMed1991

Scabies in the extended care facility. Revisited.

Infestations with Sarcoptes scabiei var hominis remain a problem in nursing home patients. While the traditional signs of scabies include burrows and red papules found on the fingerwebs, chest, waist, or genitalia, the elderly or infirm patient may have only a nonspecific pruritic eruption. Epidemics in skilled care facilities may be controlled and the scabies mite even eradicated from the institutions with appropriate diagnosis and adequate treatment of both patients and personnel and their contacts.

Aged↗
PubMed1978

Cutaneous vasculitis.

Cutaneous vasculitis is a common but confusing clinical syndrome. We report three illustrative cases demonstrating the variable nature of the process. Renal disease is generally a poor prognostic sign; therefore, the renal status should be evaluated early. The process probably represents an immune complex disorder. Although various therapies have been used, an aggressive corticosteroid regimen is the preferred mode of treatment at the current time.

Aged↗
PubMed1976

Superficial and cutaneous fungal infections: diagnosis and treatment.

Fungal infections usually have characteristics that make them easily identifiable. In most cases, clinical diagnosis can be readily confirmed by examining the lesions under Wood's light or by placing infected material in potassium hydroxide solution and examining the preparation microscopically. Dermatophytes can be rapidly detected by culturing material on the recently developed Dermatophyte Test Medium. The development of topical antifungal agents with broad spectrums of activity has considerably simplified treatment. In most cases, culture on Sabouraud's agar to determine exact genus and species before starting therapy is no longer necessary.

Antifungal Agents↗
PubMed1976

Alopecia: a systematic appraoch to diagnosis and therapy.

Alopecia is a difficult problem for the physician. It is a common reason for specialist referral because of frustration with the complexities of etiology, the impatience of the patient, and often some uneasiness of diagnosis in the mind of the physician. The concern for possible serious underlying causes, and the relative expense required to rule these out also play an important role in the early referral of these cases. The vast majority of these cases do not reflect serious disease and so do not require expensive work-ups. Trhough a systematized approach, they can be easily taken care of by the patient's primary physician. This paper presents a practical approach for the busy physician to deal with this problem quickly and easily in a systematic manner that minimizes the possibility of overlooking serious problems and defines the level of investigation necessary in most cases.

Adrenal Cortex Hormones↗