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Biomedical subjects

L E Preuss

Publications and source records attributed to L E Preuss.

15 recordsLinked to original sources
PubMed1982

Long-term alternate day steroid therapy in renal transplantation. A controlled study.

Seventy-six adult renal allograft recipients were allocated 5 months post-transplantation to daily or alternate day maintenance methylprednisolone therapy. All 15 recipients of living related kidneys and 23 recipients of cadaver kidneys were placed on the alternate day regimen, while 38 patients with cadaveric grafts remained on daily methylprednisolone. In patients on alternate day methylprednisolone, serum creatinine concentrations, frequency of acute rejection episodes, and prevalence of chronic rejection were similar to those of patients on daily steroids. Furthermore, no differences were noted in the rate of loss of graft function between recipients of cadaver kidneys on daily versus alternate day steroids. There were no differences in body weight, blood pressure, degree of hyperglycemia, or hyperlipidemia between patients on the daily or alternate day schedules. However, the prevalence of clinical osteonecrosis and the rate of infectious complications requiring hospitalization were significantly decreased in patients on alternate day methylprednisolone. We conclude that alternate day methylprednisolone therapy is as effective as daily steroids for the maintenance of graft function in renal transplant recipients. The decreased incidence of osteonecrosis and the lower frequency of infectious complications represent a strong argument in favor of alternate day steroid therapy.

Adult↗
PubMedDate not supplied

Iterative method for elimination of the Kbeta filter in dual-beam differential tissue absorptiometry.

The application of a dual photon beam to the measurement of tissue and tissue-like substances has generally required the use of a filter to attain the required monochromaticity of the lower-energy x-ray photons. In many cases this has the undesirable effect of also severely attenuating the desired low-energy beam. A method for circumventing the use of the filter is described. The technique relies on a knowledge of the initial intensities of the components of the x-ray portion of the dual beam and involves an iterative mathematical procedure. Experimental verification of the method using both tissue and nontissue substances has been carried out. R values obtained with the iterative system show good correlation with filtered values.

Body Composition↗