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Biomedical subjects

L E Ross

Publications and source records attributed to L E Ross.

At least 19 recordsLinked to original sources
PubMed2006

Legal abortion for mental health indications.

Where legal systems allow therapeutic abortion to preserve women's mental health, practitioners often lack access to mental health professionals for making critical diagnoses or prognoses that pregnancy or childcare endangers patients' mental health. Practitioners themselves must then make clinical assessments of the impact on their patients of continued pregnancy or childcare. The law requires only that practitioners make assessments in good faith, and by credible criteria. Mental disorder includes psychological distress or mental suffering due to unwanted pregnancy and responsibility for childcare, or, for instance, anticipated serious fetal impairment. Account should be taken of factors that make patients vulnerable to distress, such as personal or family mental health history, factors that may precipitate mental distress, such as loss of personal relationships, and factors that may maintain distress, such as poor education and marginal social status. Some characteristics of patients may operate as both precipitating and maintaining factors, such as poverty and lack of social support.

Abortion Applicants↗
PubMed2004

Mood changes during pregnancy and the postpartum period: development of a biopsychosocial model.

OBJECTIVE: Women are vulnerable to mood changes during pregnancy and the postpartum period. We set out to empirically test the hypothesis that biological and psychosocial variables interact to result in this vulnerability. METHOD: Using structural equation modeling techniques, we developed an integrative model of perinatal mood changes from clinical, psychosocial, hormone and mood data collected from 150 women in late pregnancy and at 6-weeks postpartum. RESULTS: In the prenatal model, biological variables had no direct effect on depressive symptoms. However, they did act indirectly through their significant effects on psychosocial stressors and symptoms of anxiety. The same model did not fit the postpartum data, suggesting that different causal variables may be implicated in postpartum mood. CONCLUSION: This model demonstrates the importance of considering both biological and psychosocial variables in complex health conditions such as perinatal mood disorders.

Adult↗
PubMed2003

Measurement issues in postpartum depression part 1: anxiety as a feature of postpartum depression.

We investigated the contribution of anxiety symptoms to scores on the Edinburgh Postnatal Depression Scale (EPDS) between 36 weeks gestation and 16 weeks postpartum in 150 women. The 3-item anxiety subscale of the EPDS accounted for 47% of the total score in late pregnancy, and 38% of the total score in the postpartum period. Two categories of anxiety were common in the perinatal period: subsyndromal, situational anxiety (in particular during the last weeks of pregnancy); and clinically significant comorbid anxiety, which was experienced by nearly 50% of clinically depressed pregnant and postpartum women. The close relationship between anxiety and depression raises questions about whether symptoms of anxiety might be more common in the perinatal period than in other depressions. A strong role for anxiety symptoms in postpartum depression, and implications for its etiology and treatment, are discussed.

Adult↗
PubMed2003

Measurement issues in postpartum depression part 2: assessment of somatic symptoms using the Hamilton Rating Scale for Depression.

Assessment of the somatic symptoms of depression in perinatal women has been debated due to potential overlap with normal physical complaints of pregnancy and childbirth. We investigated the properties of the 17-item Hamilton Rating Scale for Depression (HAMD), which includes somatic items, between 36 weeks gestation and 16 weeks postpartum in 150 women. Scores on the HAMD were highly correlated with scores on measures that avoid somatic items. Scores on somatic items were not well correlated with the total HAMD score in pregnancy, but the correlations increased at 6 weeks postpartum. In contrast, scores on HAMD item 1 ("Depression") were less well correlated with the total score at 6 weeks postpartum than prenatally, suggesting that postpartum women may be less likely to articulate their difficulties as "depression", and more likely to describe somatic complaints such as low energy or insomnia. Implications for the assessment of depression in this population are discussed.

Adult↗
PubMed1996

Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase.

A series of substituted phosphonate derivatives were designed and synthesized in order to study the ability of these compounds to inhibit the neuropeptidase N-acetylated alpha-linked acidic dipeptidase (NAALADase). The molecules were shown to act as inhibitors of the enzyme, with the most potent (compound 3) having a Ki of 0.275 nM. The potency of this compound is more than 1000 times greater than that of previously reported inhibitors of the enzyme. NAALADase is responsible for the catabolism of the abundant neuropeptide N-acetyl-aspartylglutamate (NAAG) into N-acetylaspartate and glutamate. NAAG has been proposed to be a neurotransmitter at a subpopulation of glutamate receptors; alternatively, NAAG has been suggested to act as a storage form of synaptic glutamate. As a result, inhibition of NAALADase may show utility as a therapeutic intervention in diseases in which altered levels of glutamate are thought to be involved.

Acetylation↗
PubMed1996

Alcohol and workload as factors affecting the detection of angular acceleration.

INTRODUCTION: Previous findings have demonstrated that a low blood alcohol concentration (BAC) decreases subjects' ability to detect changes in angular motion and that this effect persists after the BAC returns to zero. METHODS: Angular motion thresholds of six alcohol and six placebo subjects holding pilots' certificates were obtained under both low and high task load conditions. The alcohol subjects were tested under double blind conditions in an enclosed simulator apparatus prior to drinking, after drinking (mean BAC = 0.038%), and at a time when the alcohol subjects' BACs had reached zero. RESULTS: Alcohol subjects' mean threshold values for the three threshold test sessions were 0.361, 0.512, and 0.465 degree.s-2 and 0.292, 0.422, and 0.379 degree.s-2 for the high and low task conditions, respectively. Corresponding values for placebo subjects were 0.364, 0.37, and 0.356 degree.s-2 for the high task load condition and 0.311, 0.317, and 0.312 degree.s-2 for the low task load condition. Statistical analyses showed significant task load and sessions effects (p < 0.025). Significant alcohol by test sessions interactions were found for both high and low task load conditions (p < 0.01) with subsequent t-tests showing no alcohol-placebo differences for the pre-alcohol test session, but significant alcohol-placebo differences for the alcohol test session and the test session conducted after the subjects' BACs returned to zero. CONCLUSIONS: The results indicate that the increased threshold for detecting changes in angular motion found after alcohol ingestion is relatively insensitive to task workload and, thus, it is unlikely that attentional changes underlie the threshold increase. These data together with the finding that an elevated threshold can persist after BAC reaches zero suggest that the threshold increase after alcohol ingestion reflects changes in vestibular functioning.

Acceleration↗
PubMed1995

Professional pilots' views of alcohol use in aviation and the effectiveness of employee-assistance programs.

Pilots holding the Airline Transport Pilot certificate were surveyed about the seriousness of the alcohol problem in various areas of aviation and about the importance of a number of possible reasons why a pilot might drink and fly. They also rated a number of actions in terms of their potential effectiveness for reducing inappropriate alcohol use, and they evaluated a number of characteristics of employee-assistance programs. Respondents judged employee-assistance programs to be the best way to reduce problem drinking. They also identified areas in which currently available employee-assistance programs could be improved.

Accidents, Aviation↗
PubMed1995

Effect of alcohol on the threshold for detecting angular acceleration.

We investigated the effects of a low blood alcohol level (mean BAC = 0.037%) on subjects' ability to detect acceleration and deceleration of angular motion. The angular motion thresholds of six alcohol and six placebo subjects, all of whom had private pilot certificates, were tested under double-blind conditions in an enclosed simulator apparatus prior to drinking, after drinking, and at a time when the BAC's of alcohol subjects had reached zero. Mean threshold values for the three threshold determination sessions were 0.282, 0.376, and 0.343 degrees.s-2 respectively for the alcohol subjects, and 0.263, 0.262, and 0.262 degrees.s-2 for placebo subjects. A significant alcohol x test-session interaction (p < 0.005) reflected the elevated thresholds shown by all alcohol subjects after consuming alcohol (p < 0.001). Of the six alcohol subjects, four continued to have elevated thresholds after their BAC's reached zero (p < 0.001). Alcohol and placebo subjects showed similar performance on the ancillary tasks of maintaining altitude and reporting a specified number when it appeared on a digital display. Both groups also reported that they had experienced similar levels of discomfort symptoms before and after drinking. The results indicate that a pilot's ability to detect angular motion can be compromised by low BAC levels, and this effect may continue for some pilots after their BAC reaches zero.

Acceleration↗
PubMed1992

A modeling analysis of young drivers' judgments of accident risk due to alcohol use and other driving conditions.

Male (60) and female (60) college students who were under the legal drinking age completed a personal driving experience questionnaire and judged the probability of an accident occurring in 100 driving scenarios, half involving an intoxicated male driver and half a sober male driver. The scenarios also varied in terms of the safety levels of five other driving factors. Mathematical models derived from the probability judgments permitted measurement of the influence of the various driving factors on perceived risk. The driving factors in order of their influence on the accident probability judgments were driver intoxication-nonintoxication, vehicle speed, road conditions, driver mood and driving experience, which did not significantly differ, and the driver's experience with alcohol use. Accident probability estimates of the alcohol scenarios increased as an additive function of the other driving factors, whereas increased risk of an accident in the no-alcohol scenarios was more dependent upon multiple unsafe factors. Female students judged the probability of an accident higher overall than did male students. Subject drinking classification (abstain-light, moderate or heavy) was not related to accident probability estimates.

Accidents, Traffic↗
PubMed1992

Pilot performance with blood alcohol concentrations below 0.04%.

The effects of a low (less than 0.04%) BAC on pilot performance were investigated in a series of four experiments in which pilots flew a light aircraft simulator under alcohol and placebo conditions. The mean BACs of subjects when starting and finishing the test sessions were 0.037% and 0.028%, respectively. Two of the experiments involved demanding flight tasks under instrument meteorological conditions: complicated departure, holding, and approach procedures in one case; and VOR-use intersection problems in the other. The other two experiments involved ILS approaches under turbulence, cross wind, and simulated wind shear conditions that imposed heavy control-task loads on the pilots. Significant alcohol effects were found, but only under the heaviest workload conditions. During posttest interviews 75% of the pilots reported physical and/or mental effects due to alcohol.

Adult↗
PubMed1992

Professional pilots' evaluation of the extent, causes, and reduction of alcohol use in aviation.

Pilots holding the ATP rating were surveyed to obtain judgments concerning the seriousness of the alcohol problem in various areas of aviation, the reasons for alcohol use, and the probable effectiveness of strategies intended to reduce alcohol use in aviation. Alcohol use was judged to be a more serious problem in general aviation than in corporate, charter, regional, and major airline activities. Respondents identified the individual's inability to control alcohol use as a primary reason for drinking and flying, and they endorsed remedies that are directed toward those individuals who are seen as the source of the problem. Other factors considered important causes of drinking and flying included pilots' beliefs that they can compensate for alcohol's effects and their lack of knowledge about the rate of decrease in blood alcohol concentration (BAC) that occurs as a function of time and amount consumed.

Aerospace Medicine↗
PubMed1991

Young drivers' evaluation of driving impairment due to alcohol.

Ninety-six college students, 18-20 years of age, were selected from three drinking categories (abstain-light, moderate, and heavy) based on their self-reported drinking habits. Subjects rated the relative importance of three driving components (attention, control/maneuvering, and emergency responses) for safe driving and the impairment each component and overall driving ability would sustain after driver drinking. Impairment ratings were made of the effects of drinking the number of drinks that would have resulted in the rater having blood alcohol concentrations (BACs) of .05%, .10%, and .15%. Subjects also estimated the number of drinks that they could consume in one hour and then safely drive after after different time periods, the time they should wait before driving after drinking various amounts of alcohol, and the number of beer, wine, wine cooler, and whiskey drinks that would cause them to reach a .10% BAC. While the driving components were rated to be of approximately equal importance for safe driving, the emergency responses component was judged to be more impaired following alcohol consumption than any of the other components, or overall driving ability. Heavy drinkers judged that there was significantly less driving impairment due to alcohol than did light or moderate drinkers in the case of overall driving ability and all of the driving components except emergency responses. Heavy drinkers also judged it safe to consume a number of drinks before driving that would result in higher mean BACs than those of light and moderate drinkers. Both drinking category and gender differences were found in the estimated BAC values that would have occurred at the time of driving after waiting periods judged by subjects to be sufficient for safe driving.

Adolescent↗
PubMed1990

Naturally occurring retirement communities: a multiattribute examination of desirability factors.

This study investigated the factors important in older individuals' attraction to and satisfaction with apartment complexes that become naturally occurring retirement communities (NORCs). Quantitative measures examining the relative importance of various apartment complex attributes in attracting older and younger people to apartments that have and have not become NORCs were obtained by using a multiattribute scaling procedure. Results are presented from two main perspectives: a comparison of the factors attracting older residents to NORCs and non-NORCs; and a comparison of the factors attracting older and younger residents to NORCs.

Aged↗
PubMed1990

Pilots' knowledge of blood alcohol levels and the 0.04% blood alcohol concentration rule.

A national sample of licensed pilots was surveyed regarding their knowledge of the Federal Aviation Administration's (FAA) 0.04% blood alcohol concentration (BAC) limit, the relationship between the number of drinks and BAC, and the manner in which BAC decays with time. A majority of the 1039 respondents were unaware of the 1985 0.04% BAC rule change. In addition, many lacked an understanding of the relationship between the amount of alcohol consumed and the resulting BAC, and of the rate at which BAC decays. The number of drinks necessary to raise BAC to specific levels was frequently overestimated, and the amount of time necessary for BAC to decay was frequently underestimated. These errors were more pronounced for moderate and heavy drinkers than for abstainers and infrequent drinkers. These results suggest that pilots could have difficulty if they attempt to use the 0.04% BAC value as a guide to safety in their flying activities.

Accidents, Aviation↗
PubMed1988

Pilots' attitudes toward alcohol use and flying.

Questionnaires were sent to a national sample of licensed pilots. Respondents reported their flying experience and their drinking behavior. They also indicated the number of drinks that they believed could be safely consumed 3 hours (h) before flying or driving, and estimated the numbers of hours a person should wait, after drinking, before attempting to fly or drive. Similar questions were included regarding marijuana use. Respondents were much more conservative in their attitudes toward the use of alcohol prior to flying than prior to driving. This relationship held both for the number of drinks judged safe 3 h prior to flying or driving and for estimates of the waiting interval that would be appropriate following alcohol consumption. In addition, attitudes toward alcohol use were related to respondents' own drinking behavior, with moderate and heavy drinkers more tolerant of alcohol use in flying and driving situations than abstainers.

Adult↗
PubMed1987

Children's and adults' predictive saccades to square-wave targets.

Predictive saccades to square-wave targets were investigated in school age children and adults at target frequencies of 0.25, 0.5, 0.75, 1.0 and 1.25 Hz. Both children and adults showed predictive tracking that was greatest at the middle of the frequency range, but children's saccade latencies were greater than those of adults at frequencies of 0.5 Hz and above. The variability of saccade latencies for children and adults were comparable. These results were interpreted as indicating that both children's and adults' oculomotor systems include a prediction operator and respond to predictable stimuli in qualitatively similar, although quantitatively different, ways.

Adult↗