Biomedical subjects
Publications and source records attributed to L E Schwengle.
The sign of Leser-Trélat is usually regarded as a reliable cutaneous marker of internal malignancy. We have reviewed the literature and conclude that the evidence for a causal relation between eruptive seborrheic keratoses and cancer is meager.
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A 74-year-old female patient with an erythrodermic pityriasis rubra pilaris developed multiple seborrheic keratoses during the early stage of the skin disorder. There was no evidence of an underlying internal malignancy. Initially, the patient was treated with etretinate. The seborrheic keratoses all faded away during the next 3-4 months without any specific treatment. The possible role of retinoid treatment in the resolution of seborrheic keratoses is discussed.