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Biomedical subjects

L E Young

Publications and source records attributed to L E Young.

8 recordsLinked to original sources
PubMed1992

Mesolimbic deficits exacerbate amphetamine treatment. Clinical implications for drug abusers.

Amphetamine, a common drug used by abusers, is able to produce a schizophreniform psychosis in man. The experiment reported here examined amphetamine in relation to its role in the nucleus accumbens septi (NAS) and the globus pallidus. The effects produced by apomorphine, a direct dopamine (DA) agonist, were compared with those of amphetamine, a known indirect DA agonist. The data revealed that amphetamine in NAS-lesioned animals produced very active stereotypy which intensified with time. This effect was blocked by pallidal lesioning. Apomorphine in pallidectomised rats produced persistent stereotypy, but of diminished intensity. The results are discussed in terms of the mediating roles of the NAS and globus pallidus on behavioural sequelae.

Amphetamines↗
PubMed1987

Photoreceptor evoked potentials and phototactic behaviour in Cercaria caribbea LXXI cable.

1. Transient potential changes evoked in response to light stimuli, and presumably arising from rhabdomeric eye-spots in the cercarial body, were recorded for the first time, to our knowledge, in helminth parasites. 2. Pigmented Cercaria caribbea LXXI gave a very slowly adapting response to maintained light stimulus, while a non-pigmented variety appeared to emit a stronger, rapidly adapting response to light onset. 3. Swimming towards a directional light source is disrupted by several neuropharmacological agents, which presumably disturb synaptic transmission in the nerve/muscle system. 4. The light evoked potentials were unaffected by these same agents and therefore, appeared to be directly recorded receptor potentials.

Animals↗
PubMed1978

Nursing interventions with obese cardiac patients.

There is much conflicting data and many opinions regarding the relationship between obesity and cardiovascular disease. The best information shows that there is a relationship between multiple factors and cardiac problems. Nurses need to assist patient populations to assess their learning needs and should present material regarding multiple risk according to those needs. Classification of patient status as primary, secondary, or tertiary can assist in this process. Nurses need to help fill the void in proven data in this area by conducting longitudinal research into multiple risk factors and a variety of interventions.

Cardiovascular Diseases↗
PubMed1977

Hereditary spherocytosis and glucose-6-phosphate dehydrogenase deficiency.

The first reported case of hereditary spherocytosis (HS) and glucose-6-phosphate dehydrogenase deficiency in a black is presented. The recent literature is reviewed, with emphasis on the frequency of multiple inherited RBC defects in this ethnic group. Despite a coexisting hemoglobinopathy or enzyme deficiency, HS can be diagnosed in most cases by the peripheral blood smear, osmotic fragility curve, and family history. The implications of the double RBC abnormality are discussed, stressing the importance of splenectomy in relieving the hemolytic component due to spherocytosis.

Adult↗
PubMed1975

Remarks.

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Hematology↗