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Biomedical subjects

L Edwards

Publications and source records attributed to L Edwards.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Factors moderating the effect of oral sulfonylureas on free water clearance.

The effects of the antidiuretic agent chlorpropamide and the diuretic agent tolazamide on solute-free water clearance (CH2O) were compared in noninsulin-dependent diabetic patients undergoing water diuresis. Hyperglycemia (fasting serum glucose above 200 mg/dl) obscured the effects of these two sulfonylureas on CH2O. Thiazide or ethacrynic acid enhancement of chlorpropamide antidiuresis was also blunted by hyperglycemia and attendant osmotic diuresis. Thus, the low incidence of symptomatic hyponatremia during chlorpropamide treatment of diabetic patients may be explained by persistent hyperglycemia in such patients.

Aged↗
PubMedDate not supplied

Patient discharge planning documentation in an Australian multidisciplinary rehabilitation setting.

This article, drawing on data from 17 case studies, addresses problems in documentation of discharge planning in an Australian multidisciplinary rehabilitation center and the ways these were, or could be, overcome. The problems identified in the case studies were not specific to one discipline; they were due to inadequately defined guidelines and responsibility and poorly designed forms, and they possibly reflected the tendency for members of practice-oriented disciplines to see documentation as low on their list of priorities.

Forms and Records Control↗
PubMedDate not supplied

Beyond couvade: pregnancy symptoms in couples with a history of infertility.

Thirty-six couples with a history of infertility reported their physical, positive emotional, and negative emotional symptoms during pregnancy. The women experienced more physical symptoms than did the men. Both the men and women experienced second-trimester decreases in negative emotional symptoms and third-trimester increases in negative emotional symptoms. The women's physical symptoms also showed a second-trimester dip. Each symptom type was correlated for husbands and wives, but only 6 husbands showed evidence of couvade syndrome by exhibiting exact correspondence with their wives' symptoms. Symptom attunement appears to be a better term than couvade for most infertile men's experiences of pregnancy.

Adult↗
PubMedDate not supplied

Clinical evaluation of single-dose oral bacampicillin or ampicillin in therapy of uncomplicated gonorrhea.

Two hundred twenty-eight patients with uncomplicated gonorrhea who returned for follow-up cultures were evaluated for determination of the efficacy of three different regimens of single-dose oral treatment. The regimens included 2.4 g of bacampicillin plus 1.0 g of probenecid, 1.6 g of bacampicillin plus 1.0 g of probenecid, and 3.5 g of ampicillin plus 1.0 g of probenecid. All three regimens were highly effective in the treatment of urogenital and rectal gonorrhea but often failed cure pharyngeal gonorrhea. The highest rate of adverse reactions was reported for patients treated with 2.4 g of bacampicillin plus probenecid. The efficacies of a single oral dose of 1.6 g of bacampicillin (molar equivalent, 1.1 g of ampicillin) plus probenecid and of 3.5 g of ampicillin plus probenecid in the treatment of uncomplicated gonorrhea were equivalent as were the frequencies of adverse reactions to these two regimens.

Ampicillin↗
PubMedDate not supplied

Relationship of phosphate administration to serum and red cell phosphate concentration, erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and blood P50 in the hyperglycemic dog.

In vitro studies indicate that acute increases in intracellular phosphate concentration decrease red blood cell 2,3-diphosphoglycerate levels (G. Momsen, B. Vestergaard-Bogind, Arch Biochem Biophys 190:67, 1978). We have examined the relationship in vivo of serum phosphate concentration, red cell phosphate, 2,3-DPG and blood P50 in hyperglycemic dogs infused alternately with phosphate or chloride (control) solutions. During the 8-hr insulin infusion, serum phosphate (Pi) fell 40% in the chloride-treated animals and rose 71% in the phosphate-treated dogs (P less than 0.001, phosphate vs. control). RBC Pi concentration declined in the controls and rose significantly in the phosphate-infused dogs (P less than 0.02). Serum Pi and RBC Pi were correlated in the phosphate-managed animals (r = 0.76, P less than 0.02), but not in the controls. RBC 2,3-DPG failed to rise in either group during insulin infusion and regression analysis showed a negative correlation between serum Pi and 2,3-DPG (r = -0.90, P less than 0.005) and between RBC Pi concentration and 2,3-DPG (r = -0.84, P less than 0.02). P50 failed to change in either group during insulin treatment and for up to 24 hr after initiation of the 8-hr infusion of insulin.

2,3-Diphosphoglycerate↗