Rapid reconstitution of dendritic cells after allogeneic transplantation of CD133+ selected hematopoietic stem cells.
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Biomedical subjects
Publications and source records attributed to L Eger.
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Reported is a system of apparatures to control characteristic changes of cardiorespiratory function during different methods of endoscopic ventilation. The aim of the study is to measure and record simultaneously and continuously ECG, thoracic movement, tracheal pressure, pulmonary artery pressure and arterial oxygen pressure using transcutaneous technique. Measurements of arterial blood pressure and blood gas analysis (PaO2, PaCO2, BE, HCO3-, pH) are carried out in intervals. Four different methods of injector-ventilation are compared with the conventional laryngoscopic ventilation on the basis of a test program. Laryngoscopic ventilation as well as injectorventilation by CARDEN-Tubus make it possible to achieve a hyperoxaemic situation by normofrequent ventilation. Despite of hyperventilation it is not possible in every case to achieve an increased capillary oxygen pressure of 200 to 300 mm Hg by injector-ventilation with Venturi effect because of a smaller oxygen proportion. In jet-ventilation with N2O/O2-mixture (3:1) there is no appreciable hyperoxia, but a small reduction of systemic arterial blood pressure. With all techniques of mechanical respiration usual middle intratracheal pressure of respiration was not exceeded. Traumatic pressure of jets was only indirectly shown in steep rises of pressure by the applied technique of measurement.
To characterize the essential values of function and capacity for the comparison of different ventilation systems, a system of measurements is described which uses the following values: initial gas pressure and proportion of oxygen; jet tubes: flow area and jet pressure at a distance of 10 and 20 or 25 mm; ventilation volume and pressure, and oxygen content in a half-open lung model. Description of results with 8 ventilation systems which are applied in the practice of different institutions.
An injection respirator is described which performs effective ventilation of the lung in open systems using breathing mask, tracheal catheter or endoscope tubes. Moreover, it can be used to apply oxygen in a half-open system (IPPB).
Congenital disorders of respiration, food intake and function of the voice indicate abnormalities in the rhinolaryngotracheal or oesophageal regions of the air passages and oesophagus. They immediately need differential diagnostic clarification in interdisciplinary cooperation. Methods of a sophisticated tubus endoscopy, applied also under emergency situations, play a vital role. The therapy aims at eliminating life-threatening ventilation disorders within a short time by pharyngotracheal intubation and within a longer period by tracheostomy in order to let prenatally inhibited developments postnatally come into effect, if need be to support these differentiation processes by endoscopic interventions or to perform plastically constructive operations at a prognostically convenient time.
Three different mixed anaesthesias were compared and monitored as for the behaviour of vital functions (heart frequency, RR, ECG, respiration, pO2tc, blood gases) during endoscopy of the air passages in 3 patient groups (n = 36), using one complex measuring set-up. Hypertonic blood pressure rises and increase in the heart frequency were regularly demonstrated in all methods of anaesthesia. Initial cardiac depression with a drop of frequency and blood pressure was observed for the first time within the first minute after the injection of Hexobarbital or Radenarcon in 70 per cent of the cases. The Radenarcon-succicuran-O2 combination showed the highest rate of arrhythmia. Significantly high pO2 levels (400 torr) were attained only under pure oxygen respiration and in no case with nitrous oxide or room-air oxygen mixtures (injector respiration). The time of apnoea could be extended maximally without danger signals, provided the supply of oxygen was accordingly high.
Transcutaneous oxygen-partial-pressure-measurement of the capillary system has proved to be a successful and reliable monitoring method, also under extreme conditions of a respirating-endoscopy with pure oxygen. The feasibility of continuous recording on an ECG-recorder with good coincidence with bloody measurements can be appreciated as being very advantageous. In unphysiological high oxygen-pressure-ranges the disadvantage of the withdrawal-caused error of the bloody determination is avoided with the transcutaneous method which delivers real values.
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