Biomedical subjects

L Egri

Publications and source records attributed to L Egri.

8 recordsLinked to original sources

PubMed1998

[Possibilities for revascularization in early and late stage lunate malacia].

There are various biomechanical procedures for the treatment of lunate necrosis in the literature, but only a few deal with the possible revascularisation of the bone. We used the second dorsal metacarpal vascular bundle implantation technique in different stages of Kienböck's disease. Since 1990, twelve patients were treated by this method. In stage I-II according to Lichtman, we implanted the vessels in the lunate after excochleation and cancellous bone grafting, in stage III we used a modified form of the Graner operation and revascularised the proximalised part of the capitate. In the first group, six patients, we observed significant improvement in five cases clinically, radiologically confirmed stagnation of the process in four cases. In the second group of six patients, the clinical symptoms improved in four cases, three patients had to change work and one patient developed a pseudarthrosis between the capitate and corticocancellous block, but the proximalised part of capitate survived in all cases. Vascular bundle implantation can be a helpful method in early stages of lunate necrosis, helping to slow or to stop the progression of the disease.

Adolescent↗

PubMed1997

[Microsurgical methods of bone replacement].

Vascularized bone grafting techniques are ideal for long bone defects in the extremities. The authors report on their experience in this field. From January 1991 to 2nd November 1995, 17 patients were treated by vascularized bone grafts. In ten cases iliac crest, in six cases fibula, and in one case a radial forearm composite flap was used. All patients have shown optimal healing and good bony consolidation, except for one case of circulatory disorder of the fibula graft.

Adult↗

PubMed1996

[Comparison between various treatment methods in scaphoid pseudarthrosis].

In this study we compare the results of various methods of treatment in 159 patients who were operated on between 1980 and 1990 for scaphoid pseudarthrosis at the Budapest Central Institute for Traumatology. Rated subjectively, 84% of the results of the Russe-I plasty were regarded as good, as were 75% of the spongiosaplasty, 88% of the Ender plate synthesis, and 75% of the AO navicular screw. Of the palliative methods retaining movement, denervation with styloidectomy yielded good results. Silicon prosthesis and proximal pole resection only led to temporary improvement. In patients with severe radiocarpal arthrosis who do heavy work, even today radiocarpal stiffening is regarded as the procedure of choice. In our experience, the best functional results can be expected when immobilization is as short as possible and fixation as stable as possible - which corresponds to Ender plate synthesis according to our results.

Adolescent↗

PubMed1994

[Substitution of soft tissue defects on the lower leg and foot in septic cases].

After the spontaneous epithelialisation of the defects of soft parts so called unstable scars remain which, because of ulceration, are sources of infection, endangering both soft parts and bones. Substitution with soft tissues of adequate blood supply enables the complete sanation of the septic foci and by this the rapid healing of the patient with full function. Beside this a better cosmetic result can be achieved. In septic environment, if possible, local muscle flaps and free flaps are used, depending on the extent and localization of the defect. Experiences, gained in these operations are described.

Adult↗

PubMed1993

[Management of malacia of the os lunatum by implantation of a dorsal metacarpal vascular bundle].

In the treatment of malacia of the lunate bone, beside the prosthesis and procedures aiming the decrease of load, the revascularization of the bone is the third basic therapeutic principle. One possibility of the later, not yet current in this country, is the implantation of the metacarpal vascular bundle in the lunate bone. As far as we know we were the first to perform this operation in Hungary. In this paper our first cases are described together with a detailed description of the operative technique and we would call at the same time to further common examinations.

Adult↗

PubMed1993

[Examination of the reperfusion damage to a striated muscle: possible pathomechanism and prevention].

We have examined in a series of experiments the pathomechanisms of the damage caused by the reperfusion following ischaemia of the striated muscle. The lipid peroxidation products (thiobarbitur acid-reactive materials [TBARS]) and the glutathion state were observed comparing the behaviour of the white and red fiber types. We have found significantly higher reduced and oxydated glutathion (GSH and GSSG) and TBARS values also in physiological circumstances in the red muscle fibers. At the end of a 4 hours ischaemia period no significant alteration was found in the above parameters though both the levels of GSH and GSSG were raised their ratio however did not change. We have measured expressed change with the elevation of the GSSG/GSH rate following a 1 hour reperfusion (108% +/- 22 in the white and 490% +/- 103 in the red muscle fibers) whereas the TBARS values still did not show significant elevation. In the second hour of the reperfusion the GSSG/GSH further elevated and beside this the expressed elevation of the TBARS could also be demonstrated (164% +/- 48 in the white and 152% +/- 28 in the red fibers. During the further reperfusion lasting altogether 12 hours we did not observe a significant decrease. The time sequence of these processes suggest that the lipidüperoxidation occurs only after the total exhaustion of the antioxidant reserves of the cell. The treatment with Methylprednisolon (MP), deferoxamine (DFO) and superoxid-dismutase+catalase (SOD+CAT) diminished in both types of fibers the raise of TBARS values.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1991

Differences in glutathione status and lipid peroxidation of red and white muscles: alterations following ischemia and reperfusion.

Glutathione status and products from lipid peroxidation [measured as thiobarbituric acid reactive substances (TBARS)] were determined in red and white muscle tissue of the rat. Marked differences between both muscle types were found in reduced glutathione (GSH) and oxidized glutathione (GSSG) content, exhibiting 163% and 183%, respectively, higher levels in red than in white muscle tissue, while the ratio of GSSG/GSH showed no differences. These characteristics may be due to an adaptive mechanism related to the 48% higher baseline level of TBARS in red muscle tissue. Immediately after 4 h of tourniquet-ischemia GSH, GSSG, and TBARS were increased (16%, 32%, 45% in white muscle; 19%, 49%, and 42% in red muscle, respectively), whereas the GSSG/GSH ratio remained unchanged. During the subsequent reperfusion period, GSH decreased within 2 h by 39% in white and 89% in red muscle to a minimal level of 5 mmol/g protein in both types of muscle. No recovery from the depletion was observed up to 12 h of reperfusion. The GSH decrease was parallelled by a marked increase of the GSSG/GSH ratio (150% in white and 450% in red muscle) and followed by about 150% increase in TBARS in both muscle types. This suggests that the increase in damaging TBARS is a secondary event after depletion of cellular antioxidants. Treatment of the animals during the reperfusion period with methyl-prednisolone, deferoxamine, or superoxide dismutase and catalase did not prevent the GSH decrease, but were effective in reducing the GSSG/GSH ratio to near normal and reducing the TBARS increase by about 50%.

Animals↗

PubMed1987

Role of fluid replacement, increased oxygen availability by perfluorochemicals and enhanced RES function in the treatment of mesenteric occlusion shock.

UNLABELLED: Experiments were carried out on 183 rats to study the effect of a complex therapy for treatment of mesenteric shock. The superior mesenteric artery (SMA) was temporarily ligated for 90 min under ether anesthesia; this was followed by an analgesic treatment. After release of the ligated artery, fluid therapy was instituted by administering the equivalent of 7.5% of body weight of one of three different solutions: ringer lactate (RL), hydroxyethyl starch (HES) in RL, and perfluorochemicals (PFC, 4 g/kg b.wt. in RL with HES), the latter with the aim to improve the oxygen transport to the tissue. The same fluid therapy was carried out on rats pretreated with E. coli endotoxin. Endotoxin pretreatment was chosen to compensate the negative effect of PFC on the reticuloendothelial system (RES) as shown in previous studies. Survival time and survival rate were recorded as well as hematocrit values at different times before and after treatment. Experimental groups were: CONTROLS: (1) SMA occlusion without release; (2) 90-min occlusion without therapy. Treated animals: (3) RL therapy; (4) therapy with HES in RL; (5) therapy with PFC in RL and HES; (6), (7), and (8) identical therapies as Groups 3, 4, and 5, respectively, but with endotoxin pretreatment. Survival time increased to the same extent if HES or PFC were added to RL. There was a further increase both in survival times and rates with endotoxin pretreatment (Groups 6, 7, and 8 vs. Groups 3, 4, and 5). The highest survival time and rate were obtained in Group 8, which received PFC therapy with endotoxin pretreatment. There was a slight negative correlation between survival time and hematocrit values if all groups were considered together.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗