Herd immunity: basic concept and relevance to public health immunization practices. 1971.
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Biomedical subjects
Publications and source records attributed to L Elveback.
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The autopsy records of all people over 30 years old who died and underwent autopsy in Olmsted County from 1950 through 1979 were reviewed (n = 5558, autopsy rate approximately 50%). The hearts of 530 subjects were reexamined for the severity of coronary artery disease and this determination was compared with the recorded grade. After both record and specimen the three major coronary arteries were graded according to percent reduction in luminal area (1 = 0 to 25%; 2 = 26% to 50%; 3 = 51% to 75%; 4 = 76% to 99%; 5 = occlusion). Grades 4 and 5 were designated as significant coronary disease (SCD), and 94% to 99% of diagnoses of SCD were confirmed on reexamination. The percentage of people with SCD increased during the period 1950 to 1969 and remained high in the 1970s. Cohort analysis showed an increase in the disease in all age groups (except in the 30- to 49-year-old group for the later decades of birth). There was no change in the prevalence of myocardial infarction scars over the study period.
Factors that influence the effect of coronary artery bypass graft surgery (CABG) on employment were examined in 1427 2-year survivors from entry into the nonrandomized Mayo Clinic portion of the National Heart, Lung, and Blood Institute's prospective Coronary Artery Surgery Study. Five hundred seventy-nine patients (41%) were treated medically, 769 (54%) were treated surgically and 79 (5%) were initially treated medically but later had CABG. All groups were similar at entry with respect to age and percent working, retired or quitting work for cardiac reasons. There was a similar decline in employment from entry to 2 years in all three groups. The number who quit work for cardiac reasons was twice the number of previously disabled workers who returned to work with all three modes of therapy. Univariate and multivariate analyses were used to test the independent prognostic values of a number of variables for subsequent employment in the largest homogeneous surgical subset--496 nonretired males. Postoperative angina was the most powerful factor reducing postoperative employment. Postoperative employment was also lower if the patient was not working before surgery, was a laborer, or older than age 55 years (all p less than 0.01). Although the level of nonwork physical activity was generally increased after CABG, there was no relationship between physical activity and employment. This study confirms that employment declines after CABG, but three of the four most powerful prognostic variables were not related to surgery.
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