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Biomedical subjects

L Espinosa

Publications and source records attributed to L Espinosa.

53 records · Page 3Linked to original sources
PubMed1987

[Fulminant hepatitis in a newborn infant whose mother was a carrier of the hepatitis B surface antigen and e antibody].

The authors describe a case of fulminant hepatitis in a 12-week-old infant whose mother was an asymptomatic carrier of the hepatitis B virus surface antigen and "e" antibody, the infection being unknown at the time of birth. They emphasize the importance of hepatitis B prophylaxis in all newborn children of surface antigen carrier mothers, irrespective of the situation concerning the hepatitis B virus e antigen.

Carrier State↗
PubMed1985

[Vitamin D3 poisoning and irreversible sequela].

Twenty-four children with vitamin D intoxication and a follow-up of one to thirteen years old (means: four years and seven months) are reviewed. Over-dosage was prescribed by medical order in 66.6% of patients and by the mother herself in 16.6%. Intensity of clinical symptoms (renal, neurologic, digestive) were related with daily dose administered whilst final secuelae depends on duration of overdosage. Hipercalcemia was easily corrected by association of low calcium diet, corticoesteroids and/or furosemide in least than a month in 81% of cases. Two patients died during the acute fase and 22.7% remain with permanent damage (five in chronic renal failure, one in haemodialysis and three with low IC).

Bone Diseases, Metabolic↗
PubMed1985

[Recurrent urinary infection in girls. Natural history and therapeutic response].

A group of 39 girls with urinary tract infection are studied to analyse the clinical findings, response to treatment and natural history of the disease. All of them had more than three episodes of infection per year and renal function and initial cysto-urographic study were normal. Mean age at diagnosis was 4.8 years and the mean follow-up 3.4 years. In 7.6% of cases familial incidence was observed. During infection free periods, 35.8% of patients had urinary incontinence. 25% of recurrences were asymptomatic. Only one case developed during the follow-up a unilateral polar scar associated with grave II vesicoureteral reflux. Recurrence rate/girl/year, decrease from 3.8 during the first year to 1.5 at 5th year of follow-up. Patients who received prophylaxis with nitrofurantoin showed a clear decrease in rate of recurrence.

Child↗
PubMed1984

[Peculiarities of urinary infection in 145 infants younger than 3 months of age].

Authors have analized retrospectively 145 children with urinary tract infection (UTI) within the first 120 days of life. 67% were males, 45% of patients presented an acute onset with fever and septic appearance and 55 with a chronic illness with digestive symptoms and malnutrition (95%). Breast feeding could be a protective factor against UTI. In 66% of those less than one month old, existed perinatal infectious risk factors. This fact and the presence of septic signs and positive blood cultures (71%), give rise to the possibility that the hematogenous route be the principal infectious via in this age group. The high incidence of parenchymatous participation (75%) have no relation with the presence of obstruction. At onset 29 showed no anomalies on cysto-urography, 48% vesicoureteral reflux of various degrees and 23% obstructive anomalies. The mortality rate was 1,3% due to septic shock.

Acute Disease↗
PubMed1984

[Symptomatic urinary infection in infants less than 4 months old: outcome in 129 cases].

A series of 129 children with urinary infection during the first 120 days of life, were followed-up for periods ranging from to 1 to 16 years (means = 4 1/12 year). They have been separated in two groups, depending on urocystographic findings: (I) with mild lesions and/or reflux (99 cases) and (II) with obstructive uropathy (30 cases). All the patients in group II and those with reflux of grade IV received surgical treatment. The remaining ones received chemoprophylaxis. During the follow-up, all grade I refluxes disappeared, and so did 86% of grade II and 58% of grade III. Pyelonephritic scars are present in 34% of those kidneys with grade III reflux, 56% of grade IV and 88% of those of the group II. Permanent alteration of renal function was found almost exclusively in patients with grade IV reflux or obstructive anomalies bearing no relation with the number of recurrences of infection during the follow-up.

Adolescent↗
PubMed1984

[Xanthogranulomatous pyelonephritis in childhood: analysis of 4 cases].

A critical retrospective evaluation of four cases of xanthogranulomatous pyelonephritis (XPG) treated between 1966 and 1980. Incidence was 1.93%. Age range was from 1.5 and 24 months. Interval since first symptoms to diagnosis was between one and 14 months. Clinical presentation was nonspecific in two and urinary symptoms in the rest, abdominal mass present in all, the fourth had an onset similar to an acute leucosis. There were was a grossly dilated pelvis and calices in two patients and nonfunctioning kidney in the others, one with multiple calculi. Ureteral stenosis was present in two and three showed a vesiureteral reflux grade IV. Urinculture yielded E. coli and Proteus mirabilis. In all cases diagnosis was confirmed by macro and microscopic examination. Nephrectomy was effectively cure in all four children. All patients are well at the end of follow-up, between one and four years.

Child, Preschool↗
PubMed1980

Active chronic viral hepatitis type B in a 10-month-old child.

A case of active chronic viral hepatitis type B in a ten-month-old child is described. The condition is attributed to an exchange transfusion performed because of Rh incompatibility after which the child developed severe liver disease.

Chronic Disease↗
PubMedDate not supplied

Molecular identification of NMDA glutamate receptors expressed in bone cells.

The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor has recently been identified in bone, but the molecular composition of this receptor expressed by bone cells is unknown. NMDA receptor (NMDAR) is a hetero-oligomeric protein composed of two classes of subunits, the essential subunit NR1 and NR2A to D subunits that do not by themselves produce functional channels but potentiate NR1 activity and confer functional variability to the receptor. These subunits coassemble in different combinations to form functionally distinct NMDAR. In this study, we have investigated the molecular composition of NMDAR expressed by osteoblasts and osteoclasts in culture, using RT-PCR analysis, in situ hybridization and immunocytochemistry. Specific probes were designed for the different subunits of the NMDAR, and we showed by RT-PCR analysis that mammalian osteoclasts expressed NR2B and NR2D subunits mRNAs but not NR2A and NR2C mRNAs. Rat calvaria and MG63 osteoblastic cells also expressed several NR2 subunits mRNAs, namely NR2A, NR2B, and NR2D. In situ hybridization on isolated rabbit osteoclasts and MG63 cells has confirmed the localization of NR1, NR2B, and NR2D transcripts in osteoclasts and NR1, NR2A, NR2B, and NR2D transcripts in MG63 cells. The expression of NR2D protein by bone cells was shown by immunofluorescence. These results demonstrate for the first time that osteoblasts and osteoclasts express several NR2 subunits, suggesting a molecular diversity of NMDAR channels similar to what was shown for brain. The presence of distinct functional NMDAR on bone cells may be associated with various states of bone cell differentiation and function.

Animals↗
PubMedDate not supplied

When learning a second language does not mean losing the first: bilingual language development in low-income, Spanish-speaking children attending bilingual preschool.

This article discusses two investigations which explored the bilingual language development outcomes of comparable groups of low-income, Spanish-speaking, Mexican American children who either did or did not attended a bilingual (Spanish/English) preschool. Study 1 is a replication of a study by Rodríguez, Díaz, Duran, and Espinosa, involving a new sample of 26 children who attended bilingual preschool for one year and 20 control children who remained at home. Study 2 represents a 1-year, longitudinal follow-up of Rodríguez et al.'s, sample of children during and after the children spent another year at home or in the preschool. In both investigations, standardized, objective measures of three components of children's language proficiency (productive language, receptive language, and language complexity) in English and Spanish were obtained at the beginning and end of the academic year. Contrary to fears that have been expressed by some that early exposure to English would lead to children's native language loss, the results of both studies offered no evidence of Spanish proficiency loss for children attending bilingual preschool. Children who attended bilingual preschool, compared to those who remained at home, showed significant and parallel gains in Spanish language development as well as significant and greater increases in English language proficiency over time. Results are discussed in terms of the need for more systematic research to be conducted in this area to inform policy and practice in the early education and development of language-minority children.

Achievement↗