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Biomedical subjects

L F Cavazos

Publications and source records attributed to L F Cavazos.

At least 19 recordsLinked to original sources
PubMed1990

Restructuring education and its impact on medical education.

The United States has an education deficit that in the long term may be more harmful to the country than the serious budget and trade deficits. U.S. students are far less prepared in mathematics, chemistry, and physics than are their counterparts in Western Europe and Japan. The dropout rate among high school students, and the high and increasing rate of functional illiteracy, blight lives and represent an enormous economic loss to the nation. American education must be restructured at all levels so that local and federal funds can be used flexibly to pursue revised educational goals. Students and their families should be allowed to choose their elementary and secondary schools, and school management should be decentralized and more rooted in the community. The medical profession must become involved in elementary and secondary education, and medical faculty must be involved in their communities. Further, medical faculty must encourage minority students at all educational levels, must recruit minority medical students, and must increase the number of minority faculty members.

Education↗
PubMed1978

A systems intervention for improving medical-school-hospital interrelationships.

The large number of affiliations between medical schools and hospitals resulting from recently increased size of schools has typically been accompanied by both school-hospital and hospital-hospital interrelationship problems involving faculty and administrative personnel in all departments and at all levels. In this paper the authors describe a new technique, "systems intervention," designed specifically to deal with problems of needed change in complex organizational settings, and they illustrate its use by reporting a case study of the relationships between Tufts University School of Medicine and its associated hospitals. The process combines system analysis and behavioral science techniques to promote understanding and overcome barriers to change. Changes attributed to the systems intervention at Tufts are outlined.

Administrative Personnel↗
PubMed1977

Correlative study of the morphology and C19-steroid metabolism of benign and cancerous human prostatic tissue.

Perineal punch biopsy specimens of human prostate with benign hyperplasia (BPH), well- and poorly-differentiated adenocarcinoma and transitional-cell carcinoma were incubated with testosterone-1,2-3H and 5alpha-dihydrotestosterone-1,2-3H. Incubations were carried out using a single tissue-radiosubstrate ratio and time point. Resulting radiosteroid patterns were related to histologic and ultrastructural features of these tissues. Well differentiated neoplasms had ultrastructural characteristics closely resembling hyperplastic epithelia. Both in BPH and in well differentiated carcinomas the C19-steroids were mainly metabolized by the 17beta-hydroxysteroid pathway. In contrast, cells in poorly-differentiated adenocarcinoma and transitional-cell carcinoma lacked the cytoplasmic organelles responsible for secretion; formation of 5alpha-reduced 17beta-hydroxysteroids was decreased in these carcinomas, while conversion to 17-oxosteroid radiometabolites remained unchanged or was greatly increased. These results indicate that loss of prostatic differentiation is attended by a trend from reductive toward oxidative radiotestosterone metabolism. Even in NAPDH-supplemented preparations of the majority of poorly-differentiated tumors, there was diminished transformation to 5alpha-dihydrotestosterone, the key intracellular hormone in the expression of androgenic activity in the prostate. These findings may explain why poorly-differentiated prostatic neoplasms are frequently unresponsive to anti-androgenic therapy.

Androgens↗