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Biomedical subjects

L F Gordon

Publications and source records attributed to L F Gordon.

10 recordsLinked to original sources
PubMed1985

Computed tomography findings in clinically normal and abnormal thyroid patients.

Fifty normal volunteers had unenhanced thyroid computed tomography scans. A range of normal computed tomography densities and volumes was established for each age group. Pre- and postcontrast scans were done on 47 abnormal patients with hemorrhagic cysts, multinodular goiter, thyroiditis, papillary carcinoma, and benign adenomas. The computed tomography characteristics of each of the pathologic groups was noted for both the abnormal areas and the uninvolved part of the gland. Preliminary observations of the computed tomography characteristics of each abnormality are discussed.

Adenoma↗
PubMed1984

Computed tomography in soft tissue calcification layering.

Soft tissue calcification occurs in a variety of disorders. When it is associated with an abnormal calcium phosphorous product, it may present as large, periarticular masses that demonstrate layering on horizontal beam radiographs or computed tomography (CT). Previous reports have shown this phenomenon in idiopathic tumoral calcinosis. We report two patients with metastatic calcification of different etiologies: one patient with tumoral calcinosis and one with secondary hyperparathyroidism complicating chronic renal failure. Both showed layering on CT. The pathology of this phenomenon as well as therapeutic implications are discussed.

Adult↗
PubMed1978

Protective effect of hyperthermia against the cytotoxicity of actinomycin D on Chinese hamster cells.

Hyperthermia is being tested as an adjuvant to chemotherapy for clinical use. We elected to study the interaction of heat at 43 degrees C with actinomycin D (AMD) (0.5 microgram/ml) in tissue culture using plateau phase Chinese hamster cells. The simultaneous administration of 43 degrees C and AMD produces more than additive cytotoxicity if the duration of exposure is less than 30 minutes; however, this is quickly reversed with longer exposures with the cells developing resistance to further cytotoxicity of AMD. If heat (43 degrees C) is applied before AMD exposure, the cells also are rendered insensitive, with a greater protection observed for longer periods of heating. For example, for cells heated for 2 hours at 43 degrees C and then exposed to AMD (0.5 microgram/ml for 2 hours), cytotoxicity to AMD is decreased by a factor of 10. Heat-induced resistance to AMD persists for at least 18 hours before full recovery of AMD effect returns. The application of heat following AMD exposure also protects against the cytotoxicity of AMD. Studies using 3H-AMD demonstrate that the resistance does not correlate with reduced membrane permeability to AMD of heated cells. Attention must be given to the timing of hyperthermia when used clinically as adjuvant therapy in patients receiving AMD.

Animals↗
PubMedDate not supplied

The course of depressive symptoms over time for women who completed drug treatment.

The purpose of the present study was to (a) describe the trend in depressive symptoms in a sample of postpartum women who used cocaine and who completed drug treatment; and (b) to examine possible correlates of those trends including treatment type and selected pretreatment characteristics. Self-reported levels of depressive symptoms improved from treatment entry to discharge and remained relatively stable through three postdischarge follow-up points. Baseline level of depression was the only pretreatment factor that was correlated with the trend in depressive symptoms. And length of time in treatment, previous drug treatment, and baseline severity of drug use were not.

Adolescent↗