PubMed Health⌕ Search

Biomedical subjects

L F Perrin

Publications and source records attributed to L F Perrin.

At least 19 recordsLinked to original sources
PubMed1993

Asthma and neuropeptides.

Non-adrenergic non-cholinergic nerves, first described in the gut, were identified in the lung about twenty years ago. These fibers constitute in the airways an extensive network of nerve endings containing a great amount of neuropeptides which can influence bronchi smooth muscle tone and control airway calibre. These mediators can also modulate immune function and cellular responses characteristic of inflammation in the bronchi. It is obvious that they can play an important role in asthma, and it is likely that a better understanding of the mechanisms of action of these substances will lead to new treatments in asthma.

Asthma↗
PubMed1985

Use of acute phase protein changes to assess the effects of a nonsteroidal antiinflammatory drug (niflumic acid) on the inflammation process induced by limited plastic surgery.

Serum levels of acute phase proteins (C-reactive protein, alpha 1 acid glycoprotein, and haptoglobin) have been measured to assess the effects of a nonsteroidal antiinflammatory drug (niflumic acid). Thirty patients undergoing plastic surgery have been studied. The results obtained from this surgical model prove that nonsteroidal antiinflammatory drugs can modify acute phase response and especially acute phase proteins levels. The participation of prostaglandins in the acute phase protein variations is discussed. The authors conclude that haptoglobin could provide a convenient tool for studying some aspects of prostaglandin action in vivo.

Acute-Phase Proteins↗
PubMed1984

Reproducibility of skin tests. A comparative study of the Pepys prick test and the Morrow-Brown needle and their correlation with the serum IgE level.

Fifty patients allergic to mite were tested for D. pteronyssinus using two prick-test techniques; the classical method by Pepys and the Morrow-Brown needle. Each patient received six tests with each method on the two forearms. The evaluation of the weal areas was conducted in two ways: by weighing the shapes of the tests transferred on to paper, and by measuring the two greatest diameter lengths. No significant difference was observed between the two methods. No significant difference was observed between the measurements of the same tests carried out at 2-monthly intervals by the same examiner. With the Pepys method the weal area sizes are significantly larger than with the Morrow-Brown needle, and the variance is much greater with the Pepys technique. However, the coefficients of variation are similar and in both cases the techniques are equally reproducible. No significant difference was found in the weal sizes with regard to the injection sites on the forearm with either of the two methods. The correlation between the weal area sizes and the log of the IgE levels is closer with the Morrow-Brown needle.

Allergens↗