In accordance with a randomized double-blind experimental design, capsules of zinc sulfate, 440 mg total daily dose, and lactose placebo were administered orally to 10 normal Caucasian males for 3 weeks. Sebum secretion rates and serum zinc levels were determined prior to and following treatment. There was a statistically significant change in the before and after mean sebum secretion rates of the zinc group when compared with those of the placebo group (p less than 0.028). The results of this preliminary study indicate that supplemental zinc sulfate may reduce the quantity of skin-surface sebum. Further investigation is warranted.

Administration, Oral↗

PubMed1980

Extensive cutaneous metastases from urinary bladder carcinoma.

Herein we present an update of the literature and a report of a recent case of cutaneous metastases from transitional cell carcinoma of the urinary bladder. Cutaneous metastases from bladder carcinoma more commonly affect middle-aged or elderly men and generally herald a rapid demise. Our case is unusual because of the rather extensive area of skin involvement, rapidity of development, and occurrence in a woman.

Aged↗

PubMedDate not supplied

Randomized double-blind comparison of short-term itraconazole and terbinafine therapy for toenail onychomycosis.

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Antifungal Agents↗