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L F van Zutphen

Publications and source records attributed to L F van Zutphen.

40 records · Page 3Linked to original sources
PubMedDate not supplied

Genetic control of plasma cholesterol response in the rat.

The inheritance of the susceptibility for dietary cholesterol in the rat has been studied by testing the plasma cholesterol response in male animals from crosses between hyperresponding and hyporesponding inbred strains. Comparison of the variances of the response of genetically uniform groups (parental strains and F1 hybrid) and segregating groups (backcrosses and F2 hybrid) revealed that more than 80 percent of the observed variation can be attributed to additive genetic factors and indicated that two major genes are involved in the control of the plasma cholesterol response.

Animals↗
PubMedDate not supplied

Linkage of the gene for uncoupling protein to esterase-1,2 and haptoglobin in the rat.

Genetic analysis of a (BN x ACI)ACI backcross for the biochemical markers Es-1 and Es-2 (linkage group V) and a microsatellite marker of Ucp (chromosome 19) revealed linkage between these three loci. This linkage relationship confirms that in the rat linkage group V genes are located on chromosome 19. Genetic analysis of a (BN x LEW)LEW backcross showed that Hp is linked to Ucp, thus indicating that the Hp locus is also located on chromosome 19. These results substantiate the linkage homology of RNO 19, MMU 8, and HSA 16.

Animals↗
PubMedDate not supplied

Polymorphic microsatellite DNA markers in the rabbit (Oryctolagus cuniculus).

By searching the EMBL nucleotide database a total of 157 rabbit nuclear gene microsatellites were obtained (VAN LITH and VAN ZUTPHEN, Animal Genetics 27, 387-395, 1996). Thirteen of these were analysed by PCR to examine the degree of polymorphism of the amplified fragments in rabbits from different breeds. The 13 pairs of primers resulted in polymorphic products with an average of four alleles per microsatellite sequence (ranging between 2-11). There was a positive relationship between the longest repeat unit number in the nucleotide sequence and the number of alleles detected. The results obtained so far justify the conclusion that rabbit microsatellites extracted from the EMBL nucleotide sequence database are sufficiently polymorphic to be useful as Type 1 markers in rabbit genetic studies.

Alleles↗