Pharmacologic studies on Radix puerariae. I. Effects of puerariae on blood pressure, vascular reactivity, cerebral and peripheral circulation in dogs.
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Animals↗
Biomedical subjects
L Fan
Publications and source records attributed to L Fan.
Effect of age on pyruvate kinase and lactate dehydrogenase distribution in rat kidney.
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Age Factors↗
Experimental reorganization of host muscle cells by excretory/secretory products of infective Trichinella spiralis larvae.
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Animals↗
Evaluation of the analgesic efficacy of EMLA cream in volunteers with differing skin pigmentation undergoing venipuncture.
BACKGROUND AND OBJECTIVES: Lidocaine/prilocaine cream (EMLA) applied to intact skin for 60 minutes has been shown to reduce venipuncture pain. Recent studies have suggested that lidocaine/prilocaine cream is less effective on heavily pigmented skin. The objective of this study was to evaluate the topical anesthetic efficacy of lidocaine/prilocaine cream in volunteers with varying skin pigmentation types. METHODS: Sixty volunteers were enrolled into each of three groups based on skin pigmentation history. Subjects were randomized to receive lidocaine/prilocaine cream onto the antecubital fossa of one arm and placebo cream on the comparable location of the other arm for either 60, 90, or 120 minutes prior to venipuncture. Assessments of perceived pain associated with each venipuncture were made by the subject using a visual analog scale. RESULTS: Lidocaine/prilocaine cream applied for 60 minutes significantly (P < .0001) reduced the pain of venipuncture compared to placebo regardless of the skin pigmentation type. Pain reduction did not differ significantly across skin types (P = .7986). Additional exposure up to 120 minutes did not change the efficacy of EMLA cream. CONCLUSIONS: Lidocaine/prilocaine cream is a safe and effective topical anesthetic for reducing pain associated with venipuncture in individuals, regardless of skin pigmentation.
Administration, Topical↗
Does astaxanthin protect Haematococcus against light damage?
The photoprotective function of the ketocarotenoid astaxanthin in Haematococcus was questioned. When exposed to high irradiance and/or nutritional stress, green Haematococcus cells turned red due to accumulation of an immense quantity of the red pigment astaxanthin. Our results demonstrate that: 1) The addition of diphenylamine, an inhibitor of astaxanthin biosynthesis, causes cell death under high light intensity; 2) Red cells are susceptible to high light stress to the same extent or even higher then green ones upon exposure to a very high light intensity (4000 mumol photon m(-2)s(-1)); 3) Addition of 1O2 generators (methylene blue, rose bengal) under noninductive conditions (low light of 100 mumol photon m(-2)s(-1) induced astaxanthin accumulation. This can be reversed by an exogenous 1O2 quencher (histidine); 4) Histidine can prevent the accumulation of astaxanthin induced by phosphate starvation. We suggest that: 1) Astaxanthin is the result of the photoprotection process rather than the protective; 2) 1O2 is involved indirectly in astaxanthin accumulation process.
Chlorophyta↗